HOME >> BIOLOGY >> NEWS
Scientists seek cause for what makes good cell go bad

Genetic mutations--sudden, random and usually harmful changes to the structure of a gene--are only one factor that determines the ultimate fate of a cell. Chicago scientists have discovered that a non-genetic molecular process also can play a role, and that experimenters can influence this process in bacteria, they report in the April 1 issue of the journal Nature.

The research team, led by Philippe Cluzel, Assistant Professor in Physics at the University of Chicago, arrived at its finding by analyzing E. coli's chemotaxis system, the system that transmits the biochemical signals responsible for cell locomotion.

"We studied this simple system in bacteria as a model system for the general study of signal transduction networks," Cluzel said. "Signal transduction networks are everywhere in nature. The division of our cells is controlled by a signal transduction network, and its malfunction causes cancers."

The network that controls the movement of E. coli, a single-celled organism, is much simpler than the system that divides human cells. But signal transduction networks exhibit the same design principles across species, Cluzel said. Consequently, researchers will now attempt to apply their research methods to higher organisms.

A combination of traditional genetic experiments and computer simulations contributed to the study. "The methods they're using I think in many ways are the future of biology," said Michael North, deputy director of the Center for Complex Adaptive Systems Simulation at Argonne National Laboratory. North, who did not participate in the study but who is familiar with its findings, lauded Cluzel and his co-authors for their mathematical rigor and for pushing signal transduction research to new levels of volume and efficiency. "They were able to collect more data than anyone had in the past by a wide margin," North said.

Cluzel's team focused its study on monitoring and analyzing the intracellular signals
'"/>

Contact: Steve Koppes
skoppes@uchicago.edu
773-702-8366
University of Chicago
31-Mar-2004


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... The research team of The Hong Kong ... identification by adopting ground breaking 3D fingerprint minutiae recovery and matching ... and accuracy for use in identification, crime investigation, immigration control, security ... ... A research team led by ...
(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
(Date:3/27/2017)... 27, 2017  Catholic Health Services (CHS) has ... Society (HIMSS) Analytics for achieving Stage 6 on ... . In addition, CHS previously earned a place ... an electronic medical record (EMR). "HIMSS ... of EMR usage in an outpatient setting.  This ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... the first-ever genomics analysis platform specifically designed for life science researchers to ... of pioneering researcher Rosalind Franklin, who made a major contribution to the ...
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... Personal eye wash is a basic first ... eye at a time. So which eye do you rinse first if a dangerous substance ... Plum Duo Eye Wash with its unique dual eye piece. , “Whether its ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... , ... October 11, 2017 , ... ... the implantation and pregnancy rates in frozen and fresh in vitro fertilization ... progesterone and maternal age to IVF success. , After comparing the results from ...
Breaking Biology Technology:
Cached News: