HOME >> BIOLOGY >> NEWS
Scientists solve puzzle of how kinesin motor molecules walk or limp across cells

Biophysicists at Stanford University have finally answered one of the most fundamental questions in molecular biology: How does the tiny motor molecule, known as kinesin, move across a living cell? According to the researchers, the solution to this longstanding problem will provide new insight into how motor proteins function, and may open new avenues of investigation for the treatment of cancer and various neurodegenerative diseases, such as Alzheimer's and Huntington's.

The study, published in the Dec. 4 online edition of the journal Science, was co-authored by Steven M. Block, a professor of applied physics and of biological sciences at Stanford.

"Motion at the cellular level is a hallmark of being alive," Block said. "A fundamental question is, how did living organisms figure out how to move? The answer is they developed kinesin and several other very efficient protein motors. If kinesin were to fail altogether, you wouldn't even make it to the embryo stage, because your cells wouldn't survive. It's that important."

Discovered in 1984, kinesin is now recognized as the workhorse of the cell, hauling chromosomes, neurotransmitters and other vital cargo along tiny molecular tracks called "microtubules." Many types of kinesin and kinesin-related proteins have been discovered in the past two decades in a wide range of organisms from yeast to humans.

"Kinesin functions like a locomotive in cells to ferry cargo back and forth," Block said. "In brain cells, for example, it grabs these tiny sacs called vesicles, which are loaded with neurotransmitters that are needed for neurons to function, and moves them very long distances along microtubules."

A mere three-millionths of an inch long, a typical kinesin molecule has a tail on one end that hauls the cargo and two globular heads on the other end that alternately grab the microtubule and pull the cargo forward. One head has to be attached to the microtubule at all times for kinesin to adv
'"/>

Contact: Mark Shwartz
mshwartz@stanford.edu
650-723-9296
Stanford University
5-Dec-2003


Page: 1 2 3 4

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: