HOME >> BIOLOGY >> NEWS
Scientists switch components in cell circuits: Possible new technology, therapy

By tinkering with a few of the parts in a vital signaling circuit found in human cells, UCSF scientists have demonstrated the possibility of an entirely new technology: developing new devices or therapies by mixing and matching sub-cellular signaling components.

Like modern-day high performance machines, cells are constantly monitoring signals in their environment in order to "decide" on a course of action such as growth or movement. The signals are transmitted and processed by groups of proteins linked in specific circuits. Focusing on a protein that directs cell movement, the researchers were able to substitute key parts of the protein so that the reaction driving cell movement came under the control of new signals. Their study demonstrates that the signaling proteins are made of highly interchangeable "modules," the scientists report. This interchangeability may allow engineering of cells with new decision-making circuits, the scientists say.

"Signaling proteins and other molecules in cells talk to one another by touching or binding one another," says Wendell Lim, PhD, UCSF associate professor of cellular and molecular pharmacology. "When you look at different signaling systems in cells, you can recognize many of the same components the same subfragments of proteins linked together in different ways. We showed that the components are modular the equivalent of electronic components. By mixing and matching components we can generate novel and diverse circuits and behavior.

"It may be possible to use this technology to engineer cells that can act as cheap and robust sensors or computers, for example. You might be able to engineer cells that act like an artificial pancreas. In principle it may be possible to combat cancer by designing a signaling switch that promotes cell death only when triggered by proteins found in tumor cells."

Lim is senior author on a paper reporting this research in the September 26 issue of the journal
'"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
25-Sep-2003


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... May 27, 2020 , ... CrucialTrak, a global designer and manufacturer of biometric ... Group (CEG) to market and sell its complete line of biometric readers and ... infrastructure optimization solutions . , Brett Mason, CrucialTrak’s Director of Channel Sales ...
(Date:5/25/2020)... ... May 22, 2020 , ... Oxford Nanopore Technologies is ... of SARS-CoV-2, the virus that causes COVID-19. , The LamPORE assay is ... smaller sample numbers, to very large numbers of samples. Hardware and reagents sit ...
(Date:5/21/2020)... ... 21, 2020 , ... Agility Orthopedics, home to dedicated specialists ... is pleased to announce a partnership with Dallas-based Simple Interact to further enhance ... area, Agility Orthopedics is focused on speeding up patient workflows to enhance patient ...
Breaking Biology News(10 mins):
(Date:5/1/2020)... NEW YORK (PRWEB) , ... April 30, 2020 ... ... Ideas Awards were announced today, honoring the businesses, policies, projects, and concepts that ... is a revolutionary bioprinter for living cells, which has taken out the top ...
(Date:4/23/2020)... ... April 22, 2020 , ... Across the country, there is ... COVID-19. Virginia has only been receiving 50% to 7.7% of the personal protective ... Governor Northam told the Virginia Mercury, “While we appreciate what we’ve received from ...
(Date:4/22/2020)... ... April 21, 2020 , ... Aniara Diagnostica is pleased ... , Aniara Diagnostica, a multi-national distributor of diagnostic and research agents, as well ... product quality and cost-efficient delivery. , For Research Use Only. Not ...
(Date:4/18/2020)... ... April 17, 2020 , ... NeuroFlow ... Research (SBIR) program to support the expansion of its digital health platform enabling ... conducts a rigorous merit-based review process, adds to NeuroFlow’s recent government awards ...
Breaking Biology Technology:
Cached News: