HOME >> BIOLOGY >> NEWS
Scientists take a step nearer to creating an artificial egg using a somatic cell

Madrid, Spain: Scientists believe that they are an important step nearer to success in creating an artificial egg from the combination of the nucleus of a somatic cell and an oocyte which has had its DNA-carrying nucleus removed, a conference of international fertility experts heard today (Tuesday 1 July).

Dr Peter Nagy, from Reproductive Biology Associates, Atlanta, collaborating with the University of Connecticut, USA, told the European Society of Human Reproduction and Embryology annual conference that former approaches to haploidisation[1] using a fully mature oocyte and a resting (interphase) somatic cell had caused misaligned chromosomes during cell division. However, he was confident from his team's latest experiments that this difficulty could be overcome, even though their new approach also ran into some problems.

"We decided to initiate haploidisation at an earlier stage in the oocyte's cell cycle, when it was still immature, but this time using a somatic cell in its active (metaphase or G2/M) stage. Essentially, we took the control of the first nuclear division away from the oocyte and gave it to the somatic cell," he said.

The US-Brazilian research team[2] , working with mouse cells, removed the nucleus of the immature oocyte, then transformed the somatic cell from its diploid (46 chromosome or 2n) stage to its next (4n) stage and transferred it to the immature enucleated oocyte (ooplast).

"What we expected by doing this was that the DNA in the somatic cell would condense into chromosomes inside the somatic cell not in the ooplast and that the somatic cell would direct the chromosome alignment and initial spindle formation, which would then be normal. The nucleus of the somatic cell, at its second stage of division and correctly assembled, would then undergo chromosome segregation in the ooplast, resulting in twice its diploid nuclear content during in-vitro maturation. As a result of an artificia
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
44-0-536 772181
European Society for Human Reproduction and Embryology
1-Jul-2003


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/15/2019)... ... 2019 , ... Erchonia, the global leader in the manufacturing ... in Orlando & 18th Annual Golf Tournament. The invite-only, four-day event starts ... Melbourne. , The first day will kick off with training and roundtable discussions ...
(Date:10/10/2019)... ... 2019 , ... Mindray, a global developer of technologies and ... of Anesthesiologists 2019 Annual Meeting to visit exhibit #841 and discover the operating ... will provide more than 14,000 healthcare professionals from around the world the opportunity ...
(Date:10/8/2019)... ... 2019 , ... The future of medicine in the 21st century will focus ... longer, healthier lives. But it will be up to each individual to make healthy ... Chief Strategy Officer and Co-Founder of the Institute for Systems Biology and Senior Vice ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... (PRWEB) , ... September 24, 2019 , ... Drug resistance ... by the World Health Organization, with MRSA becoming one of the most serious concerns. ... were 1,218 reported cases of community-associated MRSA (CA-MRSA), or a seven-fold of the figure ...
(Date:9/22/2019)... ... September 20, 2019 , ... ... Neurotrophic Factor (BDNF) testing in serum . BDNF plays a vital role in ... growth and differentiation of new neurons in the brain involved in learning, memory, ...
(Date:9/17/2019)... (PRWEB) , ... September 16, 2019 , ... When a ... and kits that allow for the complete 3D characterization of tissues through the use ... transitioned into an imaging, image analysis and advanced cell culture focused contract research organization ...
(Date:9/11/2019)... ... 2019 , ... An upcoming episode of Advancements with Ted ... sequencing analysis. Check your local listings for more information. , Advancements will go ... and will explore its revolutionary pathogenic DNA analysis technology, which predicts in real-time, ...
Breaking Biology Technology:
Cached News: