HOME >> BIOLOGY >> NEWS
Scientists unlock molecular mechanism that controls cell growth

EVANSTON, Ill. Scientists at Northwestern University have identified a molecular switch that controls when and how cells grow. A team led by Richard I. Morimoto, John Evans Professor of Biology, has shown that the cell shuts down when stressed and doesnt divide until the environment is right again. These findings were published in the March 2001 issue of the journal Nature Cell Biology.

In order for living organisms to thrive, cells need to know when to grow. Environmental and physiological stress, such as that produced by toxins, a virus infection or poor nutrition, create an unhealthy environment at the molecular level. Cell growth under such conditions can result in serious problems, such as mistakes in chromosome replication or the beginnings of cancer.

"How does a cell know when its environment is bad?" said Morimoto. "Its been known for centuries that stress has a negative effect on the development and growth of organisms, but until now, we didnt know the mechanism that ties stress together with when and how cells grow."

It turns out that the signal transduction pathway, or the cascade of signals that leads to gene transcription and cell growth, is negatively regulated by a heat-shock protein called Hsp70, which acts as a stress sensor.

The protein an ancient protein found in nearly every organism on Earth patrols the cells immediate environment, in its role as constant protector. When biochemical stress builds to an unhealthy level, Hsp70 expression is rapidly activated and accumulates to high levels. The researchers showed that Hsp70 halts cell growth by binding to the protein Bag1.

In a healthy environment, Hsp70 keeps out of the way, allowing Bag1 to bind to a different protein, Raf-1, which sets the cell growth signalling process in motion. But when Bag1 is bound to Hsp70 during stressful times, it cannot bind to Raf-1 as well. When the stress ends and the numbers of Hsp70 return to normal, cell growth can continue.

"We wan
'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
8-Apr-2001


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2017)... -- The general public,s help is being enlisted in what,s thought to be ... on the human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest study ... gut. The project's goal is to help advance scientific knowledge of the ... ...
(Date:7/20/2017)... 2017 Delta (NYSE: DAL ) customers now can ... at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan ... Delta,s biometric boarding pass experience that ... now integrated into the boarding process to allow eligible Delta SkyMiles Members ...
(Date:6/23/2017)... and ITHACA, N.Y. , ... and Cornell University, a leader in dairy research, today ... bioinformatics designed to help reduce the chances that the ... the onset of this dairy project, Cornell University has ... for Sequencing the Food Supply Chain, a food safety ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the main ... people each year. Especially those living in larger cities are affected by air pollution ... of the most pollution-affected countries globally - decided to take action. , “I knew ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second time ... US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. ... US2020. , US2020’s mission is to change the trajectory of STEM education in ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee is ... honoring scientists who have made outstanding contributions to analytical chemistry and applied spectroscopy. ... world’s leading conference and exposition for laboratory science, which will be held February ...
(Date:10/9/2017)... Texas (PRWEB) , ... October ... ... study published on October 5, 2017, in the medical journal, Epilepsia, Brain ... with the gold standard, video EEG, in detecting generalized tonic-clonic seizures (GTCS) ...
Breaking Biology Technology:
Cached News: