HOME >> BIOLOGY >> NEWS
Scientists unlock molecular mechanism that controls cell growth

EVANSTON, Ill. Scientists at Northwestern University have identified a molecular switch that controls when and how cells grow. A team led by Richard I. Morimoto, John Evans Professor of Biology, has shown that the cell shuts down when stressed and doesnt divide until the environment is right again. These findings were published in the March 2001 issue of the journal Nature Cell Biology.

In order for living organisms to thrive, cells need to know when to grow. Environmental and physiological stress, such as that produced by toxins, a virus infection or poor nutrition, create an unhealthy environment at the molecular level. Cell growth under such conditions can result in serious problems, such as mistakes in chromosome replication or the beginnings of cancer.

"How does a cell know when its environment is bad?" said Morimoto. "Its been known for centuries that stress has a negative effect on the development and growth of organisms, but until now, we didnt know the mechanism that ties stress together with when and how cells grow."

It turns out that the signal transduction pathway, or the cascade of signals that leads to gene transcription and cell growth, is negatively regulated by a heat-shock protein called Hsp70, which acts as a stress sensor.

The protein an ancient protein found in nearly every organism on Earth patrols the cells immediate environment, in its role as constant protector. When biochemical stress builds to an unhealthy level, Hsp70 expression is rapidly activated and accumulates to high levels. The researchers showed that Hsp70 halts cell growth by binding to the protein Bag1.

In a healthy environment, Hsp70 keeps out of the way, allowing Bag1 to bind to a different protein, Raf-1, which sets the cell growth signalling process in motion. But when Bag1 is bound to Hsp70 during stressful times, it cannot bind to Raf-1 as well. When the stress ends and the numbers of Hsp70 return to normal, cell growth can continue.

"We wan
'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
8-Apr-2001


Page: 1 2

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
(Date:3/24/2017)... Research and Markets has announced the addition ... Trends - Industry Forecast to 2025" report to their offering. ... The Global Biometric ... of around 15.1% over the next decade to reach approximately $1,580 ... market estimates and forecasts for all the given segments on global ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , ... October 10, 2017 , ... ... and business process optimization firm for the life sciences and healthcare industries, announces ... conference in San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud ...
(Date:10/9/2017)... ... ... At its national board meeting in North Carolina, ARCS® Foundation ... Physics and Astronomy, has been selected for membership in ARCS Alumni Hall of ... Breakthrough Prize in Fundamental physics for the discovery of the accelerating expansion of the ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first ... accompanying cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using their own ...
(Date:10/5/2017)... ... , ... LabRoots , the leading provider of educational and interactive virtual ... to cancer research with a month-long promotion supporting the advancement of breast cancer research ... use promo code PinkRibbon to get 10 percent off their purchase of every the ...
Breaking Biology Technology:
Cached News: