HOME >> BIOLOGY >> NEWS
Scientists using gene chips identify a unique form of leukemia

BOSTON Dana-Farber Cancer Institute scientists have discovered that a rare but lethal blood cancer that strikes infants in their first year is a genetically distinct type of leukemia that might someday be treatable with designer drugs specifically targeted to it.

The discovery will help researchers single out the abnormal genes that make the leukemia so difficult to treat, as well as identifying new targets within the cancer cells for drugs that would be more selective than those used today. Nature Genetics will publish the findings on its Web site on Dec. 3 and in its January 2002 print edition.

This finding is very exciting to us because it forces us to think about this as a separate disease and to think about other therapies that could be designed to attack its specific weak points, says Scott Armstrong, MD, PhD, lead author of the paper.

Currently, physicians diagnose and treat the rare cancer as a particularly aggressive form of the more common Acute Lymphoblastic Leukemia, or ALL. The cancer may respond to chemotherapy at first, but tends to recur fatally. Thats why the prognosis is so much worse than for most types of childhood leukemia, which today can usually be treated effectively.

The Dana-Farber scientists and collaborators propose the name Mixed Lineage Leukemia, or MLL, for the newly identified disease, which affects fewer than 100 hundred babies annually in the United States but is typically fatal in about 60 percent of the cases.

Using powerful gene chips, the researchers say theyve found that the genetic abnormalities in the cells of this infant cancer are dramatically different from ALL, and also from AML (Acute Myelogenous Leukemia), the other common type of childhood leukemia. The pattern of gene activity in the infant cancer is so distinct that the disease warrants its own name and might be tamed with drugs designed to hit its unique set of vulnerable points.

Armstrong, who is an instructor in
'"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
2-Dec-2001


Page: 1 2 3 4

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Scientists using gene chips identify unique form leukemia

(Date:8/25/2014)... the first U.S. outbreaks of the H1N1 virus swept ... people. A university math and biology professor has used ... gain insight into how only a few infected people ... community., The fall 2009 semester hadn,t even started when ... and Wellness Services clinic11 one day, and just two ...
(Date:8/25/2014)... battery-powered DNA diagnostic device invented at New Zealand,s ... commonly used field tool for rapidly detecting suspected ... the level of infection. , The breakthrough device, ... Queenstown Molecular Biology main meeting. It takes advantage ... target DNA sequences in real-time, without the need ...
(Date:8/25/2014)... separation from a device the size of a cell ... acoustic waves, according to a team of engineers., "For ... before analysis," said Tony Jun Huang, professor of engineering ... the integrity of the cells, damages them in any ... surface acoustic waves can separate cells using very small ...
Breaking Biology News(10 mins):WSU flu outbreak provides rare study material 2WSU flu outbreak provides rare study material 3Revolutionary handheld DNA diagnostic unit allows lab-quality analysis in the field 2Tilted acoustic tweezers separate cells gently 2
(Date:8/26/2014)... , Aug. 26, 2014  That,s Nice LLC, ... markets, today announced the formation of a new dedicated ... development. The expanded team will combine current and new ... at That,s Nice. Guy Tiene ... to lead the team. Tiene was previously Director of ...
(Date:8/26/2014)... InstantGMP, Inc., the only cloud-based manufacturing execution ... structure with increased user accounts to help current and ... Part 11 requirements. , “We want to help our ... said Rick Soltero, President of InstantGMP. “We found ... to have separate accounts for multiple quality managers and ...
(Date:8/26/2014)... August 26, 2014 Formedix, the ... announced the release of Transform for MARVIN: the ... Data Capture (EDC) product line. It was developed ... allows integration with MARVIN, the EDC and Clinical ... study setup time, by allowing instantaneous visualization of ...
(Date:8/26/2014)... 2014 /PRNewswire-iReach/ -- The crowdfunding campaign for PosturePulse ... on the popular crowdfunding platform Kickstarter. Backers have already ... biofeedback belt. The $75,000 funding goal for the campaign ... product. Photo - http://photos.prnewswire.com/prnh/20140825/139254 ... the lower back that silently vibrates if the wearer ...
Breaking Biology Technology:That's Nice Announces Expanded Offering For Strategic Content And Public Relations 2That's Nice Announces Expanded Offering For Strategic Content And Public Relations 3Introducing Transform for MARVIN: Providing Further Flexibility for CROs and Sponsors in Partnership with XClinical 2PosturePulse, A Biofeedback Posture-Improving Belt, Improves Posture While Sitting or Standing 2
Cached News: