HOME >> BIOLOGY >> NEWS
Scientists using gene chips identify a unique form of leukemia

BOSTON Dana-Farber Cancer Institute scientists have discovered that a rare but lethal blood cancer that strikes infants in their first year is a genetically distinct type of leukemia that might someday be treatable with designer drugs specifically targeted to it.

The discovery will help researchers single out the abnormal genes that make the leukemia so difficult to treat, as well as identifying new targets within the cancer cells for drugs that would be more selective than those used today. Nature Genetics will publish the findings on its Web site on Dec. 3 and in its January 2002 print edition.

This finding is very exciting to us because it forces us to think about this as a separate disease and to think about other therapies that could be designed to attack its specific weak points, says Scott Armstrong, MD, PhD, lead author of the paper.

Currently, physicians diagnose and treat the rare cancer as a particularly aggressive form of the more common Acute Lymphoblastic Leukemia, or ALL. The cancer may respond to chemotherapy at first, but tends to recur fatally. Thats why the prognosis is so much worse than for most types of childhood leukemia, which today can usually be treated effectively.

The Dana-Farber scientists and collaborators propose the name Mixed Lineage Leukemia, or MLL, for the newly identified disease, which affects fewer than 100 hundred babies annually in the United States but is typically fatal in about 60 percent of the cases.

Using powerful gene chips, the researchers say theyve found that the genetic abnormalities in the cells of this infant cancer are dramatically different from ALL, and also from AML (Acute Myelogenous Leukemia), the other common type of childhood leukemia. The pattern of gene activity in the infant cancer is so distinct that the disease warrants its own name and might be tamed with drugs designed to hit its unique set of vulnerable points.

Armstrong, who is an instructor in
'"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
2-Dec-2001


Page: 1 2 3 4

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists visualise cellular handmaiden that restores shape to proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/1/2016)... 1, 2016 Favorable Government Initiatives ... and Criminal Identification to Boost Global Biometrics System Market ... TechSci Research report, " Global Biometrics Market By ... and Opportunities, 2011 - 2021", the global biometrics market ... on account of growing security concerns across various end ...
(Date:5/9/2016)... -- Elevay is currently known as the ... high net worth professionals seeking travel for work   ... there is still no substitute for a face-to-face meeting. ... deal with a firm handshake. This is why wealthy ... citizenship via investment programs like those offered by the ...
(Date:4/26/2016)... 27, 2016 Research and ... Biometrics Market 2016-2020"  report to their offering.  , ... The analysts forecast the global multimodal biometrics ... during the period 2016-2020.  Multimodal biometrics ... such as the healthcare, BFSI, transportation, automotive, and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... Ginkgo Bioworks , a leading organism design company ... as one of the World Economic Forum,s Technology ... companies. Ginkgo Bioworks is engineering biology to manufacture ... the nutrition, health and consumer goods sectors. The ... Fortune 500 companies to design microbes for their ...
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
(Date:6/24/2016)... NC (PRWEB) , ... June 24, 2016 , ... Researchers ... the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are ... to read it now. , Diagnostic biomarkers are signposts in the blood, lung ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... announce the launch of their brand, UP4™ Probiotics, into Target stores nationwide. The ... is proud to add Target to its list of well-respected retailers. This list ...
Breaking Biology Technology:
Cached News: