HOME >> BIOLOGY >> NEWS
Scientists visualise cellular handmaiden that restores shape to proteins

A gigantic protein complex responsible for looking after bent out of shape proteins has been visualised by scientists working in Japan and the UK.

The structure of the chaperonin complex of the bacteria Thermus thermophilus reveals clues about how the important molecule may do its job of folding new or damaged proteins within cells.

Led by Professor So Iwata of Imperial College London, the team of scientists announce their findings in this month's edition of the journal Structure (August 2004).

The complex comprises three separate parts - two identical 'cage' units lashed back to back, and a 'cap' unit that sits atop the cage, acting as a stopper. The cage contains the unwound, or denatured, protein, while the chaperonin goes about refolding its shape using the cellular energy source, ATP.

The structure of the chaperonin complex is one of the largest and most difficult solved by scientists. Each unit of the cage or cap is made up of seven separate polypeptide chains.

"It's huge," said Professor Iwata. "The cavity can accommodate even very large proteins inside. It makes the perfect environment for the protein to fold."

It is the second structure of a chaperonin complex to be reported by scientists, and is visualised at a resolution of 2.8 Angstroms. The first was published in 1997 by the group of the late Professor Paul Sigler at Yale University, USA.

Unlike the first structure, taken from the chaperonin of gut bacterium Escherichia coli, the Thermus thermophilus structure is a more natural structure revealing the irregular oval interior of the cage's subunits.

Thermus thermophilus is a highly thermophilic bacteria, first found living in deep-sea hot vents. It contains proteins thought to be very similar to those found in the energy powerhouses of plant and animal cells, the mitochondria.

Immediately, the largest users of this new knowledge are biochemists working on the protein and bioinforma
'"/>


17-Aug-2004


Page: 1 2 3

Related biology news :

1. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
2. Scientists sequence genome of kind of organism central to biospheres carbon cycle
3. Scientists find nanowires capable of detecting individual viruses
4. Scientists discover potential new way to control drug-resistant bacteria
5. Scientists explore genome of methane-breathing microbe
6. Scientists decipher genetic code of biothreat pathogen
7. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins
8. Scientists discover proteins involved in spread of HIV-1 infection
9. Scientists fear new Ebola outbreak may explain sudden gorilla disappearance
10. Scientists reinvent DNA as template to produce organic molecules
11. Scientists identify compounds that mimic calorie restriction

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/28/2018)... ... July 28, 2018 , ... ... Kong Polytechnic University (PolyU), has been honoured with the International Association for Wind ... of wind engineering and bridge engineering in research, education, and application. Professor Xu ...
(Date:7/26/2018)... ... July 26, 2018 , ... Shirley Holmlund, an evidence-based ... biofield energy healing treated Vitamin D3 on the strength and health of bones. ... 290% improvement in bone mineralization and over 100% increase in ALP, a bone-specific ...
(Date:7/25/2018)... ... July 25, 2018 , ... A pioneering Duchenne muscular dystrophy clinical trial ... annual Mt. Kinabalu climb to raising awareness of the need to enroll patients. ... with patients and families willing to participate in a clinical trial,” said Catherine Jayasuriya, ...
Breaking Biology News(10 mins):
(Date:8/9/2018)... ... August 09, 2018 , ... Simpson Gumpertz & Heger (SGH) ... building owners and managers for a full-day discussion on health care and life ... Boston for the first time on Thursday, 13 September 2018, at Harvard Medical ...
(Date:8/7/2018)... ... 06, 2018 , ... PetPace , the makers of a smart health-monitoring ... announced the launch of a groundbreaking study to identify and eventually predict problems and ... of pregnant dogs sponsored by PetPace and conducted by Dr. Smadar Tal, DVM, DACT, ...
(Date:7/31/2018)... ... July 31, 2018 , ... Leading regenerative ... methods for extracting and using adipose tissue-derived stem cells to treat or prevent ... While this patent covers Canada specifically, VetStem has been issued similar patents that ...
(Date:7/31/2018)... ... 31, 2018 , ... Mahoney Environmental , a leading ... new website. The new website has been designed with improved functionality and navigation, ... Innovative to build a website created for the customer. The newly redesigned site ...
Breaking Biology Technology:
Cached News: