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Screen siblings, parents of infants with severe heart abnormalities

HOUSTON (Sept. 7, 2004) Brothers and sisters as well as parents of infants born with severe, life-threatening abnormalities of the left side of the heart should be screened for less severe, but related, heart problems, said researchers at Baylor College of Medicine (BCM) in Houston.

In a new study in the September issue of the journal Pediatrics, Drs. Jeffrey Towbin, BCM professor of pediatrics at BCM, and John Belmont, BCM professor of molecular and human genetics, found that these first degree relatives of children with severe defects of the left side of the heart had a fivefold increased risk of having an abnormality called bicuspid aortic valve.

The finding solidifies the currently held belief that such disorders are related to several genes - as few as two and as many as six, said Belmont.

"What this tells us, is that multiple other relatives including parents and siblings are at risk for progressive heart disease and that they should be screened by a cardiologist," said Towbin, also chief of cardiology at Texas Children's Hospital. At present, specialists do not recommend screening of close relatives of these children with severe heart defects.

A normal aortic valve has three cusps or "flaps" that open and close to regulate the flow of blood. A bicuspid valve has only two. Individuals with this disorder are predisposed to heart valve infections and a narrowing of the valve later in life.

Approximately 0.9 percent of people in the general population have bicuspid aortic valve, but the rate among brothers, sisters and parents of these infants is five times greater, said Belmont.

"This is an impressive statistic, as a significant number of these individuals will develop symptomatic disease later in life, and could require catheter or surgical procedures on the heart," Towbin said.

The infants' severe heart defects included congenital aortic valve stenos
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Contact: Kimberlee Barbour
kbarbour@bcm.tmc.edu
713-798-7971
Baylor College of Medicine
7-Sep-2004


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