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Screening technique streamlines search for anticancer drugs

astin, works.

Erastin is especially interesting to researchers because it seems to kill cancer cells differently than many drugs on the market. Instead of inducing cell death as do many cancer drugs--a process known as apoptosis--erastin seems to kill the cancer cell by an unknown mechanism.

"The most immediate thing is to figure out how erastin works and try to understand that molecular mechanism in detail," Stockwell added.

The engineered cancer cells used in this study were created by William Hahn and Stephen Lessnick at Dana Farber Cancer Institute. The study was funded in part by the National Cancer Institute and the Burroughs Wellcome Fund.


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Contact: Melissa Withers
withers@wi.mit.edu
617-258-7403
Whitehead Institute for Biomedical Research
26-Mar-2003


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