HOME >> BIOLOGY >> NEWS
Sea Grant researchers isolate new antibiotic from fish

Raleigh, N.C. North Carolina Sea Grant researchers are reporting the discovery of a new peptide antibiotic in fish that may have implications for treating diseases in both humans and animals, according to the November 15th issue of the peer-review journal, Nature.

Named piscidins after the Latin term "pisces" for fishes, the antibiotics were isolated from mast cells in hybrid striped bass. Mast cells are the most common tissue immune cell found in fish and other vertebrates, including humans. They are present in many tissues, including the skin, gills, and gastrointestinal tract. This is the first time that researchers have isolated a peptide antibiotic from mast cells of any animals, including humans. However, it is unclear whether fish mast cells are from the same lineage as mammal mast cells.

"The peptide antibiotics or piscidins have the potential to fight important bacterial pathogens of both fish and mammals, including multi-drug resistant bacteria," said Ed Noga, professor at the North Carolina State University College of Veterinary Medicine, and head of the research team that made the discovery.

"The antibiotics could be a useful template for designing new drugs because they are novel structures and not related to any known and currently used antibiotic," notes Noga. "With the development of antibiotic-resistant bacteria, there is an urgent need to find new types of antibiotics that can fight these resistant pathogens."

"While mast cells are one of the most common immune cells of vertebrates, their role as a critical line of defense has been uncertain," he added. "However, if any type of peptide antibiotic is also present in human mast cells, it could have important implications for treating human diseases, including asthma, skin allergies and certain types of arthritis, because of the prominent role that mast cells play in these diseases."

North Carolina Sea Grant Director Ron Hodson points out that the research
'"/>

Contact: Ed Noga
ed_noga@ncsu.edy
919-515-6236
National Sea Grant College Program
14-Nov-2001


Page: 1 2

Related biology news :

1. Grant advances biochemical engineering laboratory
2. GlaxoSmithKline Drug Discovery and Development Research Grant Program 2004
3. Grant from GE Foundation to University of Houston to strengthen math, tech pipeline
4. McGill Centre for Intellectual Property Policy receives $3 million SSHRC Grant
5. Grant promotes marine ornamental fish aquaculture
6. Grant of powerful computer to Rutgers-Newark will increase understanding of brain activity
7. Grant renews funding of research toward cloning primates
8. Lipids get the spotlight in new NIGMS Glue Grant
9. Grant funds research to develop tissue-engineered solutions for heart disease
10. Grant strengthens research arm of Penn State Hershey Medical Centers ALS Clinic
11. Sea Grant News & Notes for March 26, 2003

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sea Grant researchers isolate new antibiotic from fish

(Date:4/22/2014)... research projects study the effects of temperature and precipitation ... However, an important component of climate research, the UV-B ... in collaboration with their colleagues from the Universities in ... from the U.S. NASA space agency in such a ... influence of UV-B radiation on organisms. , The basic ...
(Date:4/22/2014)... another way of asking him or her to behave ... cells of the immune system tend to misbehave with ... these cells are known to misbehave similarly during spaceflight, ... cells to better understand how our immune systems change ... on Aging, part of the National Institutes of Health, ...
(Date:4/22/2014)... Recent projects in two Minnesota cities demonstrate how ... projects continue a ten year program in New ... plans tailored to local conditions. , "Our goal ... protect themselves," said program co-leader Latham Stack, of ... have already worsened. We help communities move beyond ...
Breaking Biology News(10 mins):UV-radiation data to help ecological research 2For an immune cell, microgravity mimics aging 2For an immune cell, microgravity mimics aging 3For an immune cell, microgravity mimics aging 4For an immune cell, microgravity mimics aging 5Minnesota projects offer hope and practical help to communities facing more extreme storms 2
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... throughput research solutions, today announced that Lupin Limited, one ... of Freeslate’s CM Protégé PharmD System for ... in Mumbai, India, is focused on a wide range ...
(Date:1/14/2014)... San Diego, CA (PRWEB) January 14, 2014 ... based on the products of cells grown under simulated ... an international license agreement with Suneva Medical, Inc. for ... media (CCM). , This agreement is an ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo ... institutes from the National Institutes of Health (NIH) to ... more effective treatments to patients on a faster timeline. ... Translational Sciences (NCATS) and the National Eye Institute (NEI) ...
(Date:1/14/2014)... Ontario , Jan. 14, 2014   Kinaxis ®, provider ... SCM ) and sales and operations planning ( S&OP ) ... Biomanufacturing Summit , which will be held at the ... the conference, join Kinaxis customer Elisabeth Kaszas , Director ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
Cached News: