HOME >> BIOLOGY >> NEWS
'Search and destroy' protein turns tables on HIV

MINNEAPOLIS / ST. PAUL -- A human protein that mutates the AIDS virus (HIV) and holds potential for keeping the disease at bay has been discovered and its function described by a team led by Reuben Harris of the University of Minnesota. The new protein (called APOBEC3F) and one described previously (APOBEC3G) can directly mutate HIV. Such proteins--called retroviral restrictors--may contribute to HIV resistance in some people. Harris, an assistant professor of biochemistry, molecular biology and biophysics, and colleagues at the university report the discovery in a paper to be published online June 24 in the journal Current Biology.

In an individual infected with HIV, the virus uses the human cellular machinery to assemble new viral particles. But sometimes those particles contain time bombs: human APOBEC proteins that hitch a ride in the particles and mutate the virus' genetic material after it has infected a new host cell.

Unfortunately for us, the AIDS virus has evolved a counterdefense. It produces a protein called VIF (viral infectivity factor), which triggers the destruction of the retroviral restrictors, thereby preventing mutations from occurring. What scientists don't know is whether some HIV-resistant people have forms of the retroviral restrictor proteins that can evade VIF and avoid destruction.

When DNA from the HIV virus is inserted into the human genome, it sometimes bears the scars of encounters with the APOBEC proteins. The two proteins leave different mutational "signatures," and the signature of APOBEC3F occurs more often.

This, said Harris, indicates that it might be less vulnerable to the virus' VIF counterdefense. Indeed, using a model HIV system, Harris and colleagues showed that APOBEC3F was less susceptible to VIF than APOBEC3G. Moreover, said Harris, the two proteins can account for all the anti-HIV mutational signatures apparent in HIV DNA of AIDS patients. But what function the proteins perform in non-H
'"/>

Contact: Deane Morrison
morri029@umn.edu
612-624-2346
University of Minnesota
24-Jun-2004


Page: 1 2

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. Researchers identify protein promoting vascular tumor growth
3. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
4. Experimental drug shown to block mutant protein causing blood disease
5. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
6. Images of tail of protein needed for cell multiplication suggest anticancer drug targets
7. New dye directly reveals activated proteins in living cells
8. Disruption of protein-folding causes neurodegeneration, mental retardation
9. A new protein is discovered to play a key role in cancer progression
10. Optimizing proteins death domain halts leukemia in laboratory study
11. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Search and destroy protein turns tables HIV

(Date:6/29/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ) ... Biomedical Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... America Biomedical Sensors market is estimated at $0.65 billion ... period 2014-2020 The near future will bring ... of each individual. These sensors can be set to ...
(Date:6/26/2015)... 26, 2015 ATL Technology, LLC, a top provider ... in single use solutions, headquartered in Springville, Utah ... California corporation with locations in ... Jose, Costa Rica ). This acquisition will ... with ATL Technology,s existing facility in Costa ...
(Date:6/25/2015)... 25, 2015 According to ... (Swipe & Area), Technology, Material (Optical Prism, Piezoelectric, ... Security & Others) & Geography - Global Forecast ... said market is expected to reach $14,500.07 Million ... Browse 76 market Tables and 109 ...
Breaking Biology News(10 mins):Latin America Biomedical Sensors Market Report 2015-2020 2ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4
(Date:6/25/2015)... 2015 Research ... the addition of the  "2015 Market ... Diagnostics Industry: Oncogenes, Biochemical Markers, Lymphokines, ... Labs, POC Locations"  report to ... http://photos.prnewswire.com/prnh/20130307/600769) , A new ...
(Date:6/25/2015)... ... June 25, 2015 , ... The American Brain Tumor ... Patient and Family Conference, Providing and Pursuing Answers: Advances in Research, Treatment and ... Suites Hotel, July 24-25, 2015. , “As advances in research accelerate the arrival ...
(Date:6/25/2015)... SAN DIEGO , June 25, 2015  BioMed ... that Illumina, Inc. (NASDAQ: ILMN ), a world ... unlocking the power of the genome, has signed a ... innovative scientific research building in Cambridge, England ... environment and access to the highly skilled workforce in ...
(Date:6/25/2015)... , June 25, 2015 ... Arzneimittel-Überprüfungs- und -Authentifizierungsdienstleistungen, führte am 24. und ... am Main das 2. Eco ... Informations-Veranstaltung zum Thema Sicherheit für Patienten in ...      (Logo: http://photos.prnewswire.com/prnh/20150610/748687) , ...
Breaking Biology Technology:Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 2Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 3Nationally Recognized Brain Tumor Experts to Speak at American Brain Tumor Association Patient and Family Conference 2BioMed Realty And Illumina Announce New Build-To-Suit Laboratory Building In Cambridge's Growing Life Science Cluster 2BioMed Realty And Illumina Announce New Build-To-Suit Laboratory Building In Cambridge's Growing Life Science Cluster 3Symposium zur Richtlinie über gefälschte Arzneimittel - mit Aegate in Deutschland 2Symposium zur Richtlinie über gefälschte Arzneimittel - mit Aegate in Deutschland 3
Cached News: