HOME >> BIOLOGY >> NEWS
Search for cholesterol absorption genes narrows to two chromosome regions

Two people eat the same egg, cheese and ham muffin for breakfast, yet one absorbs significantly more cholesterol into his or her blood than the other. Why?

The answer, and all of its implications for combating heart disease, remains stubbornly hidden within our DNA. In recent genetic studies with lab mice, however, researchers at The Rockefeller University have begun to close in on the culprit genes.

"By determining the genetic basis behind the observation that some people absorb 25 percent of cholesterol from their diet, while others absorb up to 75 percent, we hope to develop new treatments to protect this latter group," says senior co-author Jan. L. Breslow, M.D., head of The Rockefeller University's Laboratory of Biochemical Genetics and Metabolism and former national president of the American Heart Association.

The researchers hope that the identification of genes that regulate cholesterol absorption in mice will lead them to the location of similar genes in humans - and ultimately to the development of drugs that specifically reduce cholesterol absorption and protect against coronary heart disease, the number one cause of death in the United States.

In the Dec. 10 issue of the Proceedings of the National Academy of Sciences (published online Nov. 22), the Rockefeller scientists report the use of mouse "genetic linkage mapping" technology to narrow the location of genes responsible for regulating the absorption of plant fatty molecules called "plant sterols" - markers of cholesterol absorption - to two distinct regions on chromosome 2 and 14.

While the exact location of the genes has not been deduced, the results indicate that the researchers have indeed uncovered their general vicinity: one of the putative sites has an incredibly high probability - a billion to one - of carrying the suspected genes.

"We are excited because our data analysis shows that cholesterol absorption genes are very likely hiding in chr
'"/>

Contact: Whitney Clavin
clavinw@rockefeller.edu
212-327-7900
Rockefeller University
5-Dec-2002


Page: 1 2 3 4

Related biology news :

1. Search and destroy protein turns tables on HIV
2. Search for macular degeneration genes narrows
3. Search beneath lawns provides insight into backyard biodiversity
4. Searching for the real waterworld
5. Search for schizophrenia genes takes an unplanned turn
6. Searching for a genetic needle in a genome haystack
7. Searching for the secrets of drug-free transplants
8. Searching for new medications to treat alcoholism
9. Searching for biochemical markers in children of alcoholics
10. Search and support for the rare white abalone is on; sex must occur with close neighbors
11. Investigators Identify Suspect In Search For Stress-Sniffles Link

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/10/2016)... 10, 2016   Unisys Corporation (NYSE: UIS ... (CBP) is testing its biometric identity solution at the ... to help identify certain non-U.S. citizens leaving the country. ... designed to help determine the efficiency and accuracy of using ... and will run until May 2016. --> ...
(Date:3/9/2016)... 9, 2016 Nigeria ... more than 23,000 public service employees either did not ... their salary unlawfully.    --> Nigeria ... that more than 23,000 public service employees either did ... receiving their salary unlawfully.    --> DERMALOG, ...
(Date:3/8/2016)... N.C. , March 8, 2016   ... sensor technology, today announced it has secured $11M ... by GII Tech, a new venture fund being ... with additional participation from existing investors TDF Ventures ... the funds to continue its triple-digit growth and ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... (PRWEB) , ... April 30, 2016 , ... The MIT ... textile design, the bioLogic team explored how bacterial properties can be applied to fabric ... using Natto bacteria, which move in response to humidity change. The team harvested Natto ...
(Date:4/29/2016)... ... April 29, 2016 , ... Summit for Stem Cell has received ... of a patient-specific stem cell therapy for the treatment of Parkinson’s disease. The Summit ... Loring at The Scripps Research Institute in San Diego, CA. , The ...
(Date:4/28/2016)... ... April 28, 2016 , ... Connecticut Innovations ... companies, today announced the launch of VentureClash , a $5 million global ... , “VentureClash looks to attract the best early-stage companies here in Connecticut, around ...
(Date:4/27/2016)... ... 27, 2016 , ... Shimadzu Scientific Instruments (SSI) will be ... Business Conference and Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products ... can stop by booth 1021 to learn how Shimadzu’s instruments can help improve ...
Breaking Biology Technology:
Cached News: