Seat of cellular bus system for protein passengers found by Dartmouth Medical School researchers

Hanover, NH For some proteins made deep within a cell, those that work elsewhere in the body have a complex journey aboard carrier vessels with many possible stops before they exit the cell and continue through the blood to reach their destination. Now Dartmouth Medical School biochemists have discovered a key receptor for sorting which proteins stay and which leave, documenting for the first time what many scientists theorized but had not confirmed about how proteins travel through cells for export.

Their results, published in the November 16 Science, help resolve a major piece of the cell traffic puzzle, paving the way for further understanding of how hormones such as insulin as well as other important factors are conveyed through cells for secretion into the blood stream. The authors are Charles Barlowe, PhD, associate professor of biochemistry and William J. Belden, a graduate student.

Transporting proteins that need to get out of the cell to function is essential. After they are manufactured on membranes in the cell interior, the proteins are captured in little vesicles that take them to the cell boundary to be discharged. Packaging the proteins to board the vesicles takes a series of steps not yet well delineated.

"Internal membranes have thousands of proteins in them and some of those proteins depend on vesicles to travel to another location. But the first step is getting it into a vesicle. Thats called sorting," says Barlowe.

He makes the analogy of a bus. "If there is a bus to carry passengers and the passengers need seats, then if we look at the bus carefully we should be able to find some seats." Barlowe, using bakers yeast as a model system, has found a seat on the cellular bus.

A popular cell transport model holds that a receptor will bind to a protein that needs to travel and capture it into the vesicle. However, no receptors that actually operate on this theory of selected transport had been found. Now

Contact: Hali Wickner
Dartmouth Medical School

Page: 1 2 3

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. Israeli scientists reveal the plan of a key cellular machine
3. Unicellular organisms contribute more nitrogen to ocean that reported earlier
4. Scientists visualise cellular handmaiden that restores shape to proteins
5. Stroking up cellular therapy
6. Carnegie Mellon neuroscientist develops tool to image brain function at the cellular level
7. Molecular traffic cop directs cellular signals
8. University of Chicago scientists pinpoint cellular cause of SIDS
9. UCSD team determines cellular stress within body is critical
10. UNC scientists block cellular enzyme activity involved in cancer progression
11. HIV takes cellular opportunities to aid infection

Post Your Comments:

(Date:11/12/2015)... , Nov. 11, 2015   Growing need ... analytical tools has been paving the way for ... determination of discrete analytes in clinical, agricultural, environmental, ... being predominantly used in medical applications, however, their ... sectors due to continuous emphasis on improving product ...
(Date:11/9/2015)... Nov. 9, 2015  Synaptics Inc. (NASDAQ: SYNA ... announced broader entry into the automotive market with a ... the pace of consumer electronics human interface innovation. Synaptics, ... ideal for the automotive industry and will be implemented ... Europe , Japan , ...
(Date:10/29/2015)... 29, 2015 Daon, a global leader in ... released a new version of its IdentityX Platform ... North America have already installed IdentityX v4.0 ... a FIDO UAF certified server component as ... activate FIDO features. These customers include some of the ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015 /PRNewswire/ - Aeterna Zentaris Inc. ... its business and prospects remain fundamentally strong and ... (zoptarelin doxorubicin) recently received DSMB recommendation to continue ... following review of the final interim efficacy and ... Primary Endpoint in men with heavily pretreated castration- ...
(Date:11/24/2015)... Malaysia , Nov. 24, 2015  Asia-Pacific ... contract research organisation (CRO) market. The trend of ... in lower margins but higher volume share for ... capacity and scale, however, margins in the CRO ... Organisation (CRO) Market ( http://www.frost.com/sublib/display-report.do?id=P86A-01-00-00-00&src=PR ), finds ...
(Date:11/24/2015)... ... 2015 , ... Copper is an essential micronutrient that all ... copper is also toxic to cells. With a $1.3 million award from the ... a systematic study of copper in the bacteria Pseudomonas aeruginosa (P. aeruginosa), a ...
(Date:11/24/2015)... , ... November 24, 2015 , ... This fall, global ... competitive events in five states to develop and pitch their BIG ideas to improve ... each state are competing for votes to win the title of SAP's Teen Innovator, ...
Breaking Biology Technology:
Cached News: