HOME >> BIOLOGY >> NEWS
Seat of cellular bus system for protein passengers found by Dartmouth Medical School researchers

Hanover, NH For some proteins made deep within a cell, those that work elsewhere in the body have a complex journey aboard carrier vessels with many possible stops before they exit the cell and continue through the blood to reach their destination. Now Dartmouth Medical School biochemists have discovered a key receptor for sorting which proteins stay and which leave, documenting for the first time what many scientists theorized but had not confirmed about how proteins travel through cells for export.

Their results, published in the November 16 Science, help resolve a major piece of the cell traffic puzzle, paving the way for further understanding of how hormones such as insulin as well as other important factors are conveyed through cells for secretion into the blood stream. The authors are Charles Barlowe, PhD, associate professor of biochemistry and William J. Belden, a graduate student.

Transporting proteins that need to get out of the cell to function is essential. After they are manufactured on membranes in the cell interior, the proteins are captured in little vesicles that take them to the cell boundary to be discharged. Packaging the proteins to board the vesicles takes a series of steps not yet well delineated.

"Internal membranes have thousands of proteins in them and some of those proteins depend on vesicles to travel to another location. But the first step is getting it into a vesicle. Thats called sorting," says Barlowe.

He makes the analogy of a bus. "If there is a bus to carry passengers and the passengers need seats, then if we look at the bus carefully we should be able to find some seats." Barlowe, using bakers yeast as a model system, has found a seat on the cellular bus.

A popular cell transport model holds that a receptor will bind to a protein that needs to travel and capture it into the vesicle. However, no receptors that actually operate on this theory of selected transport had been found. Now
'"/>

Contact: Hali Wickner
Hali.Wickner@dartmouth.edu
603-650-1520
Dartmouth Medical School
15-Nov-2001


Page: 1 2 3

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. Israeli scientists reveal the plan of a key cellular machine
3. Unicellular organisms contribute more nitrogen to ocean that reported earlier
4. Scientists visualise cellular handmaiden that restores shape to proteins
5. Stroking up cellular therapy
6. Carnegie Mellon neuroscientist develops tool to image brain function at the cellular level
7. Molecular traffic cop directs cellular signals
8. University of Chicago scientists pinpoint cellular cause of SIDS
9. UCSD team determines cellular stress within body is critical
10. UNC scientists block cellular enzyme activity involved in cancer progression
11. HIV takes cellular opportunities to aid infection

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... April 11, 2017 NXT-ID, Inc. (NASDAQ: ... company, announces the appointment of independent Directors Mr. Robin ... its Board of Directors, furthering the company,s corporate governance and ... Gino Pereira ... look forward to their guidance and benefiting from their considerable ...
(Date:4/4/2017)...   EyeLock LLC , a leader of iris-based ... Patent and Trademark Office (USPTO) has issued U.S. Patent ... an iris image with a face image acquired in ... 45 th issued patent. "The ... the multi-modal biometric capabilities that have recently come to ...
(Date:3/29/2017)...  higi, the health IT company that operates the ... , today announced a Series B investment from ... The new investment and acquisition accelerates higi,s strategy to ... population health activities through the collection and workflow integration ... collects and secures data today on behalf of over ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... Oct. 10, 2017 SomaGenics announced the receipt ... to develop RealSeq®-SC (Single Cell), expected to be the ... RNAs (including microRNAs) from single cells using NGS methods. ... need to accelerate development of approaches to analyze the ... "New techniques for measuring levels of mRNAs in ...
(Date:10/9/2017)... 2017  BioTech Holdings announced today identification and ... ProCell stem cell therapy prevents limb loss in ... demonstrated that treatment with ProCell resulted in more ... compared to standard bone marrow stem cell administration.  ... reduction of therapeutic effect.  ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness Center ... the needs of consumers who are incorporating medical marijuana into their wellness and ... , As operators of two successful Valley dispensaries, The Giving Tree’s two founders, ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first commercially ... cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using their own facilities, ...
Breaking Biology Technology:
Cached News: