HOME >> BIOLOGY >> NEWS
Seat of cellular bus system for protein passengers found by Dartmouth Medical School researchers

Hanover, NH For some proteins made deep within a cell, those that work elsewhere in the body have a complex journey aboard carrier vessels with many possible stops before they exit the cell and continue through the blood to reach their destination. Now Dartmouth Medical School biochemists have discovered a key receptor for sorting which proteins stay and which leave, documenting for the first time what many scientists theorized but had not confirmed about how proteins travel through cells for export.

Their results, published in the November 16 Science, help resolve a major piece of the cell traffic puzzle, paving the way for further understanding of how hormones such as insulin as well as other important factors are conveyed through cells for secretion into the blood stream. The authors are Charles Barlowe, PhD, associate professor of biochemistry and William J. Belden, a graduate student.

Transporting proteins that need to get out of the cell to function is essential. After they are manufactured on membranes in the cell interior, the proteins are captured in little vesicles that take them to the cell boundary to be discharged. Packaging the proteins to board the vesicles takes a series of steps not yet well delineated.

"Internal membranes have thousands of proteins in them and some of those proteins depend on vesicles to travel to another location. But the first step is getting it into a vesicle. Thats called sorting," says Barlowe.

He makes the analogy of a bus. "If there is a bus to carry passengers and the passengers need seats, then if we look at the bus carefully we should be able to find some seats." Barlowe, using bakers yeast as a model system, has found a seat on the cellular bus.

A popular cell transport model holds that a receptor will bind to a protein that needs to travel and capture it into the vesicle. However, no receptors that actually operate on this theory of selected transport had been found. Now
'"/>

Contact: Hali Wickner
Hali.Wickner@dartmouth.edu
603-650-1520
Dartmouth Medical School
15-Nov-2001


Page: 1 2 3

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. Israeli scientists reveal the plan of a key cellular machine
3. Unicellular organisms contribute more nitrogen to ocean that reported earlier
4. Scientists visualise cellular handmaiden that restores shape to proteins
5. Stroking up cellular therapy
6. Carnegie Mellon neuroscientist develops tool to image brain function at the cellular level
7. Molecular traffic cop directs cellular signals
8. University of Chicago scientists pinpoint cellular cause of SIDS
9. UCSD team determines cellular stress within body is critical
10. UNC scientists block cellular enzyme activity involved in cancer progression
11. HIV takes cellular opportunities to aid infection

Post Your Comments:
(Date:7/31/2015)... Den 10. internationale konference om Genomik (ICG-10, ... - 25. oktober i Shenzhen , ... i år. Siden starten i 2006 er ICB blevet ... og er en af de mest dynamiske, entusiastiske og ... nylige gennembrud og fremskridt inden for ,omik,-forskning, som yderligere ...
(Date:7/31/2015)... de julio de 2015 BGI llevará a cabo ... del 22 al 25 de octubre de 2015, en ... conferencia celebra su décimo aniversario este año. Desde su ... de las reuniones anuales más influyentes del mundo en ... las conferencias científicas más dinámicas, entusiastas y amenas. ...
(Date:7/31/2015)... SHENZHEN, China , 31 de julho de 2015 ... Genômica (ICG-10, www.icg-10.org ) será realizada pela BGI de ... China . A conferência está ... inauguração em 2006, a ICG se tornou uma das ... e um dos encontros científicos mais dinâmicos, entusiastas e ...
Breaking Biology News(10 mins):Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
(Date:7/30/2015)... , July 30, 2015  With over 60,000 customers across the globe, ISN ... connect 450 hiring organizations with more than 60,000 safe and reliable contractors in over 80 countries. ... ... ... Headquartered in Dallas, TX ...
(Date:7/30/2015)... ST. LOUIS, July 30, 2015 ... period in 2014) , Reported sales were $697 ... of 2014.  Sales grew organically by 8%, and changes ... Recent acquisitions increased sales by 1%. , By ... 8% in Applied and 11% in SAFC Commercial. ...
(Date:7/30/2015)... NY (PRWEB) , ... July 30, 2015 , ... As part of its 2015 growth ... material and technical service business units, Whitehouse Laboratories is pleased to announce ... be adjacent to the Container Center of Excellence and will be strictly dedicated to basic ...
(Date:7/29/2015)... July 30, 2015 Sanofi, ... for the second quarter of 2015. CEO ... and its performance in different businesses. ... http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire Topics covered in ... - Performance drivers - ...
Breaking Biology Technology:ISN Reaches Over 60,000 Worldwide Customers 2ISN Reaches Over 60,000 Worldwide Customers 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 2Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 4Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 5Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 6Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 7Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 8Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 9Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 10Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 11Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 12Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 13Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 14Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 15Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 16Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 17Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 18Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 19Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 20Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2
Cached News: