Seattle Researchers Zero In On Location Of Gene For Inherited Prostate Cancer; Gene Also Linked To Brain Cancer

evious epidemiological studies also have shown an increased risk of brain and central-nervous-system tumors in families with clusters of prostate cancer. These observations led the Seattle researchers to evaluate the possible link between prostate and brain cancers.

The research is funded by CaP CURE, the Association for the Cure of Cancer of the Prostate, founded by former Wall Street financier Michael Milken. Dr. Leroy Hood, professor and chair of the UW Department of Molecular Biotechnology, persuaded CaP CURE to donate funds to establish the Seattle-based Prostate Cancer Genetics Consortium at the UW and the Hutchinson Center. The primary aim of the consortium is to unravel the genetic origins of the disease.

CaP CURE now provides more than $2 million a year to this and related projects. Blood samples from the PROGRESS family members were processed and frozen at the Hutchinson Center, where they were turned over to Ostrander's group for DNA extraction. Dr. Mark Gibbs from Ostrander's group and Drs. Richard McIndoe and Lisa Chakrabarti from Hood's group performed the genotyping and worked with Dr. Gail Jarvik, a UW mathematical geneticist, to pool the data for linkage analysis.

"PROGRESS is an outstanding collaboration between the Hutchinson Center and the UW," says Ostrander, also an associate member of the Hutchinson Center's Clinical Research Division. "It works because everyone contributes something unique. This is the future of genetics research."

The PROGRESS study represents a significant ongoing collaboration between epidemiologists, molecular biologists and geneticists from both institutions. "Hood's team leads the field in the development of robotics, high-throughput DNA and protein sequencing systems, and software development to handle the data," Ostrander says. "Using tools of just five years ago, a lab was doing well to complete 250 genotypings a week; PROGRESS has boosted that weekly rate to 15,000."

The researchers have been ag

Contact: Kristen Woodward
Fred Hutchinson Cancer Research Center

Page: 1 2 3

Related biology news :

1. Agronomy, crop, and soil science societies to meet Oct. 31 to Nov. 4 in Seattle
2. Sleepless over Seattle: Migrating songbirds forgo sleep but keep their wits
3. Seattle, New York researchers to receive neuroscience prize endowed by UNC scientist
4. Worlds largest scientific society convenes regional meeting June 14-17 in Seattle
5. Five Seattle scientists selected as Howard Hughes Medical Institute investigators
6. Trade, science, risk, precaution: Issues for Seattle
7. Researchers determine genetic cause of Timothy syndrome
8. Researchers find color sensitive atomic switch in bacteria
9. Researchers identify protein promoting vascular tumor growth
10. Researchers devise potent new tools to curb ivory poaching
11. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria

Post Your Comments:

(Date:5/30/2020)... , ... May 29, 2020 , ... ... digital transformation for enterprises globally, has collaborated with EchoNous Inc. to develop the ... It can measure systolic heart function, which has been clinically tested versus expert ...
(Date:5/28/2020)... CHICAGO and FORT WORTH, Texas (PRWEB) , ... ... ... clinical stage biopharmaceutical company, announced today that interim results from their 1801 Phase ... Society of Clinical Oncology (ASCO) Annual Meeting which will take place virtually on ...
(Date:5/21/2020)... ... May 19, 2020 , ... ... of operations management solutions, today introduced BioMed to their award-winning computerized maintenance ... for connecting the people and systems around biomedical engineering to better allocate ...
Breaking Biology News(10 mins):
(Date:6/23/2020)... ... 2020 , ... Kerafast Inc. , developers of an ... availability of the Delta-G-VSV Pseudotyping System for coronavirus research applications. The system, developed ... viral entry and COVID-19 vaccine effectiveness at just biosafety level 2 (BSL-2) containment. ...
(Date:6/23/2020)... ... June 22, 2020 , ... Regen Suppliers, the ... This includes buy three, get the fourth unit free with no limit on ... exosomes, known as exosomes, have been a game changer for regenerative therapies. The ...
(Date:6/23/2020)... ... June 23, 2020 , ... Nobilis Therapeutics, a biopharmaceutical company ... filed an Investigational New Drug application (IND) with the U.S. Food & Drug ... candidate NBTX-001 in patients with panic disorder (PD). , "Adding a PD trial ...
(Date:6/11/2020)... HOUSTON (PRWEB) , ... June 08, 2020 , ... ... first universal vaccine platform delivered through the use of proprietary clean viral vectors, ... vaccine in the United States. Greffex’s platform is the world’s most successful ...
Breaking Biology Technology:
Cached News: