HOME >> BIOLOGY >> NEWS
Security Code Helps Immune Cells Attack Foe And Spare Self

ST. LOUIS, Mo., July 24, 1998 -- A report in today's issue of Science helps answer a question that has had scientists scratching their heads: How do immune cells tailor their responses to invading microbes while ignoring the body's own cells?

The part of the cell that detects harmful organisms has to punch in a code before the cell will go on the offensive, the researchers have found. Punching in just part of the code is as useless as entering the wrong security code into a lock.

"People have been trying to identify the steps that occur in the resting cell and during activation, but previous methods failed to reveal this, so no one could make heads or tails of it," says lead researcher Paul M. Allen, Ph.D., the Robert L. Kroc Professor of Pathology at Washington University School of Medicine in St. Louis. "We tried a different approach, and an elegant solution to this question emerged."

One of Allen's graduate students, Ellen Neumeister Kersh, is the paper's lead author. Andrey S. Shaw, M.D., associate professor of pathology, also took part in the study, which was funded by the National Institutes of Health.

The researchers studied helper T cells, a key component of the cellular immune system. When the supply of these cells dwindles, as in AIDS patients, the consequences are dire.

Helper T cells patrol the body, checking for harmful microbes. Other parts of the immune system blow an invader's cover by posting fragments of its proteins on its surface or on the surface of a cell where it's hiding out. Helper cells read these fragments -- called antigens -- like cops checking out a license plate. If the plate is foreign, they make the appropriate response. They may kill the microbe directly, help a killer T-cell dispose of a virus-infected cell or stimulate immune cells that manufacture antibodies.

Helper cells use receptors on their surface to read antigenic displays. But instead of getting close
'"/>

Contact: Linda Sage
sage@medicine.WUSTL.edu
314-286-0119
Washington University School of Medicine
24-Jul-1998


Page: 1 2 3

Related biology news :

1. University of Pittsburgh, Carnegie Mellon University establish Biomedical Security Institute to address bioterrorism, public health threats
2. False Security: You Cant Always Believe The Results Of A Genetic Test
3. Software Helps Decipher Genomes Of Higher Organisms
4. Nutrition Therapy Helps Patients Emotionally, Research Shows
5. ASU Professor Helps In Fight To Protect Japanese Pika Habitat
6. Whitehead Study Supports Existence Of Ancient RNA World, Helps Provide Insight Into Early Evolution Of Life
7. Duke Study Helps Explain How Cells Divvy Up Genes During Reproduction
8. Transplanted Skeletal Muscle Mimics Heart Muscle; Helps Failing Heart Pump, Duke Researchers Say
9. NASA Research Helps Map Protein Structures -- Key In The Development Of New Disease-Fighting Drugs
10. Auditory Scene Analysis Helps Find Mates
11. UF Researchers Innovative Fence Helps Control Sand Flies

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Security Code Helps Immune Cells Attack Foe And Spare Self

(Date:10/16/2014)... can be cultivated efficiently, they are anything but ... by monoculture cultivation is becoming increasingly evident. Despite ... form and are regarded as the sole possibility ... quite wrongfully, finds Bernhard Schmid, an ecology professor ... novel form of agriculture and forestry. After all, ...
(Date:10/15/2014)... risk from strains of influenza virus increases with the ... become complacent that the most substantial threats have been ... pandemics arise when a new virus strain – against ... spreads in the human population. There have been five ... of which – the 1918 Spanish Flu – cost ...
(Date:10/15/2014)... Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market releases photos and video ... Square on Monday October 13 th . ... Tunnel and angel investor Mr. Chad A. Verdi ... of NXT-ID thanked his investors and employees "for their work and ...
Breaking Biology News(10 mins):Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3
(Date:10/20/2014)... -- GenVec, Inc. (NASDAQ: GNVC ) today announced the ... board of directors effective on October 24, 2014.   Dr. Horovitz ... its chairman from June 2006 to November 2013.  During his ... and Audit Committees of the board.  "We ... service to GenVec, and its stockholders," said Wayne T. ...
(Date:10/20/2014)... Rochelle, Virginia (PRWEB) October 20, 2014 ... of NDA Partners LLC, announced today that Ellen ... and legal support for the pharmaceutical industry, has ... and manager of its legal services practice. ... reports and expert witness and testimony, to top ...
(Date:10/19/2014)... OCTOBER 20-22, 2014: The ... ABIM will take place at the Congress ... 2014 is now available at http://www.abim.ch ... and organizations from all over the globe ... the latest products and developments on the ...
(Date:10/19/2014)... Asian Automatic patient billing report defines and segments the ... The Automatic patient billing market in Asia is estimated ... a developing CAGR of 7.2% from 2013 to 2018. ... patient billing market, to get an idea of the ... the segmentation of this market in the same region, ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
Cached News: