HOME >> BIOLOGY >> NEWS
Security Code Helps Immune Cells Attack Foe And Spare Self

ST. LOUIS, Mo., July 24, 1998 -- A report in today's issue of Science helps answer a question that has had scientists scratching their heads: How do immune cells tailor their responses to invading microbes while ignoring the body's own cells?

The part of the cell that detects harmful organisms has to punch in a code before the cell will go on the offensive, the researchers have found. Punching in just part of the code is as useless as entering the wrong security code into a lock.

"People have been trying to identify the steps that occur in the resting cell and during activation, but previous methods failed to reveal this, so no one could make heads or tails of it," says lead researcher Paul M. Allen, Ph.D., the Robert L. Kroc Professor of Pathology at Washington University School of Medicine in St. Louis. "We tried a different approach, and an elegant solution to this question emerged."

One of Allen's graduate students, Ellen Neumeister Kersh, is the paper's lead author. Andrey S. Shaw, M.D., associate professor of pathology, also took part in the study, which was funded by the National Institutes of Health.

The researchers studied helper T cells, a key component of the cellular immune system. When the supply of these cells dwindles, as in AIDS patients, the consequences are dire.

Helper T cells patrol the body, checking for harmful microbes. Other parts of the immune system blow an invader's cover by posting fragments of its proteins on its surface or on the surface of a cell where it's hiding out. Helper cells read these fragments -- called antigens -- like cops checking out a license plate. If the plate is foreign, they make the appropriate response. They may kill the microbe directly, help a killer T-cell dispose of a virus-infected cell or stimulate immune cells that manufacture antibodies.

Helper cells use receptors on their surface to read antigenic displays. But instead of getting close
'"/>

Contact: Linda Sage
sage@medicine.WUSTL.edu
314-286-0119
Washington University School of Medicine
24-Jul-1998


Page: 1 2 3

Related biology news :

1. University of Pittsburgh, Carnegie Mellon University establish Biomedical Security Institute to address bioterrorism, public health threats
2. False Security: You Cant Always Believe The Results Of A Genetic Test
3. Software Helps Decipher Genomes Of Higher Organisms
4. Nutrition Therapy Helps Patients Emotionally, Research Shows
5. ASU Professor Helps In Fight To Protect Japanese Pika Habitat
6. Whitehead Study Supports Existence Of Ancient RNA World, Helps Provide Insight Into Early Evolution Of Life
7. Duke Study Helps Explain How Cells Divvy Up Genes During Reproduction
8. Transplanted Skeletal Muscle Mimics Heart Muscle; Helps Failing Heart Pump, Duke Researchers Say
9. NASA Research Helps Map Protein Structures -- Key In The Development Of New Disease-Fighting Drugs
10. Auditory Scene Analysis Helps Find Mates
11. UF Researchers Innovative Fence Helps Control Sand Flies

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Security Code Helps Immune Cells Attack Foe And Spare Self

(Date:11/6/2014)... A groundbreaking paper from a team of Florida State ... how plants could adapt to and survive environmental swings ... in the latest issue of the journal The ... complex of DNA and proteins) is organized in a ... some genes are turned on and others are turned ...
(Date:11/5/2014)... biology in the UTSA College of Sciences, is ... to receive a two-year $300,00 National Science Foundation ... The funding supports President Obama,s BRAIN Initiative, a ... technology that will demystify complex brain processes. ... are broken into the interactions of multiple components, ...
(Date:11/4/2014)... the right amount of death at the right time ... to new research that could help in understanding animal ... , In a paper in the journal Trends ... and European colleagues conclude that the kind of positive ... of individuals, or mortality, depends on the size and ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3When less is more: Death in moderation boosts population density in nature 2
(Date:11/27/2014)... Calcivis, a medical devices ... decay, today announces that it has completed a ... Imaging System. The Calcivis Caries Activity ... consumable combination designed to transform the assessment and ... a unique, proprietary bioluminescence approach combined with a ...
(Date:11/26/2014)... 2014 2014 Deep Research Report ... and in-depth research report on the Ammonium Bifluoride ... definition, classification, application, and industry chain structure as ... international market analysis, including China’s domestic market as ... Asia, China, Japan etc. regions) industry analysis covering ...
(Date:11/26/2014)... , Nov. 26, 2014 Space is one ... of space requires astronauts to maintain consistently high levels ... and prevent potential errors and accidents. Despite the importance ... about how cognition is affected by prolonged spaceflight, and ... Now, Penn Medicine researchers are poised to help the ...
(Date:11/26/2014)... November 26, 2014 PMG Research, Inc. ... PMG Research is a network of sites that provide clinical ... over 2 million patient lives through its partnerships with large ... of 11 hub site locations in the Southeastern United States ... term of the board will be held by: ...
Breaking Biology Technology:Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 2Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 3Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 2Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3
Cached News: