HOME >> BIOLOGY >> NEWS
Security Code Helps Immune Cells Attack Foe And Spare Self

ST. LOUIS, Mo., July 24, 1998 -- A report in today's issue of Science helps answer a question that has had scientists scratching their heads: How do immune cells tailor their responses to invading microbes while ignoring the body's own cells?

The part of the cell that detects harmful organisms has to punch in a code before the cell will go on the offensive, the researchers have found. Punching in just part of the code is as useless as entering the wrong security code into a lock.

"People have been trying to identify the steps that occur in the resting cell and during activation, but previous methods failed to reveal this, so no one could make heads or tails of it," says lead researcher Paul M. Allen, Ph.D., the Robert L. Kroc Professor of Pathology at Washington University School of Medicine in St. Louis. "We tried a different approach, and an elegant solution to this question emerged."

One of Allen's graduate students, Ellen Neumeister Kersh, is the paper's lead author. Andrey S. Shaw, M.D., associate professor of pathology, also took part in the study, which was funded by the National Institutes of Health.

The researchers studied helper T cells, a key component of the cellular immune system. When the supply of these cells dwindles, as in AIDS patients, the consequences are dire.

Helper T cells patrol the body, checking for harmful microbes. Other parts of the immune system blow an invader's cover by posting fragments of its proteins on its surface or on the surface of a cell where it's hiding out. Helper cells read these fragments -- called antigens -- like cops checking out a license plate. If the plate is foreign, they make the appropriate response. They may kill the microbe directly, help a killer T-cell dispose of a virus-infected cell or stimulate immune cells that manufacture antibodies.

Helper cells use receptors on their surface to read antigenic displays. But instead of getting close
'"/>

Contact: Linda Sage
sage@medicine.WUSTL.edu
314-286-0119
Washington University School of Medicine
24-Jul-1998


Page: 1 2 3

Related biology news :

1. University of Pittsburgh, Carnegie Mellon University establish Biomedical Security Institute to address bioterrorism, public health threats
2. False Security: You Cant Always Believe The Results Of A Genetic Test
3. Software Helps Decipher Genomes Of Higher Organisms
4. Nutrition Therapy Helps Patients Emotionally, Research Shows
5. ASU Professor Helps In Fight To Protect Japanese Pika Habitat
6. Whitehead Study Supports Existence Of Ancient RNA World, Helps Provide Insight Into Early Evolution Of Life
7. Duke Study Helps Explain How Cells Divvy Up Genes During Reproduction
8. Transplanted Skeletal Muscle Mimics Heart Muscle; Helps Failing Heart Pump, Duke Researchers Say
9. NASA Research Helps Map Protein Structures -- Key In The Development Of New Disease-Fighting Drugs
10. Auditory Scene Analysis Helps Find Mates
11. UF Researchers Innovative Fence Helps Control Sand Flies

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Security Code Helps Immune Cells Attack Foe And Spare Self

(Date:5/21/2015)... -- According to a new market ... Services), by Applications (Surveillance (Airborne, Maritime, Land), Threat ... & Defense & Commercial) - Global Forecast to ... expected to grow from $7252.0 Million in 2015 ... Annual Growth Rate (CAGR) of 6.6%. ...
(Date:5/21/2015)... , May 21, 2015 The ... potential of music for health, today announced a collaborative ... . The partnership will center on collaboration on original ... a first step in the collaboration, The Sync Project ... on "Music as Medicine" in the 2015-2016 academic year.  ...
(Date:5/20/2015)... , May 20, 2015 ... ) has announced the addition of ... Global Iris Recognition Market"  report to ... ,This research service analyses trends in ... government and commercial sectors, globally. Despite ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2
(Date:5/21/2015)... Imagine being able to probe ... of others. Being able to read faces and enjoy ... to anticipate their thoughts and actions like never before. ... to create unique abstract paintings and video, or, play ... a first-person-shooter as it creates action, dialog, and outcomes ...
(Date:5/21/2015)... , May 20, 2015 Research and ... the addition of the "2015 Global Survey ... their offering. The primary goal of ... flow cytometry instruments and reagents. Key information the ... the selection of flow cytometers, predominantly used applications ...
(Date:5/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/x4b7kw/top_technologies ) has ... HW_Technical Insights" report to their offering. ... in the Health and Wellness sector and has identified ... impact in the year 2015. The research service provides ... and wellness technologies that are anticipated to have the ...
(Date:5/20/2015)... , May 20, 2015  Health eCareers, the ... healthcare organizations with job seekers looking for the ... a new mobile and online tool dedicated exclusively ... industry. SHIFT enables employers to quickly ... travel nursing, per diem and other temporary positions, ...
Breaking Biology Technology:5 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2Global Survey on Flow Cytometry Adoption Trends 2015 2Top Technologies in the Health and Wellness Industry 2015 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 3
Cached News: