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Security Code Helps Immune Cells Attack Foe And Spare Self

t, I've fulfilled the criteria, so now I can go ahead.' But if the antigen belongs to the host, the complete code wouldn't be entered, preventing T cells from attacking the body's own cells."

Why foreign antigens trigger full phosphorylation and self antigens don't is the next part of the puzzle to be solved.

The research has no immediate clinical applications. "But we need to understand how these complex receptors work before we can intervene in autoimmune disease," Allen says. "This knowledge also might help us find ways to switch on helper cells when we want to boost the fight against infectious disease."

Kersh EN, Shaw AS, Allen PM. Fidelity of T cell activation through multistep T cell receptor z phosphorylation. Science, July 24, 1998.


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Contact: Linda Sage
sage@medicine.WUSTL.edu
314-286-0119
Washington University School of Medicine
24-Jul-1998


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