HOME >> BIOLOGY >> NEWS
Select research highlights from current AACR journals

From the September 1 issue of Cancer Research:

  • Aberrations in the receptor protein dystroglycan may lead to either muscular dystrophy or the development of carcinomas. Whereas several molecular defects in muscle disease have been characterized, little is known about such changes in carcinoma cells. Singh et al. identified multiple post-translational modifications that modulate dystroglycan function in these aberrant cells. Novel defects in carcinoma cells arising in this important cell adhesion molecule are similar to defects recently identified in muscular dystrophies. The research was conducted at the Lawrence Berkley National Laboratories, Berkley, Calif,; the University of Iowa, Iowa City, Iowa; and California Pacific Medical Center Research Institute, San Francisco, Calif.

    Among research findings featured in the September 1 issue of Clinical Cancer Research are:

  • Heat therapy increases the efficacy of tumor treatment with melphalan, an alkylating agent used in cancer therapy for ovarian cancer and certain bone marrow tumors. In rat models for fibrosarcomas, Abdel-Wahab et al. documented that heat treatment with warm water heightened the response of tumors to high doses of melphalan. The effect was synergistic, but not related to heat-promoted increased uptake of the drug. The studies were conducted at Duke University Medical Center, Durham, N.C.

  • Two inhibitors of steroid synthesis used to treat hormone-dependent breast cancer in postmenopausal women pack a significant beneficial side effect in laboratory animals. Exemestane and letrozole was shown to significantly prevent bone loss, enhance bone mechanical strength and lower serum cholesterol levels. The inhibitor drugs act by interfering with estrogen synthesis and depleting estrogen concentrations in the blood, according to the study by Goss et al., conducted at the University of Toronto, Toronto, Ontario.

    Included among the articles pub
    '"/>



  • Contact: Russell Vanderboom, PhD
    vanderboom@aacr.org
    215-440-9300
    American Association for Cancer Research
    1-Sep-2004


    Page: 1 2

    Related biology news :

    1. Selected estrogen compounds modify risks of vein clotting, a response to hormone replacement theraphy
    2. News briefing: Foods of the future: Selecting and designing foods for a healthy 2025
    3. Aldo Leopold Leadership Program Selects First Cohort
    4. Genetic Screening May Be Tool For Selecting Cancer Treatment, Research Suggests
    5. Ligand Scientists Discover Tissue-Selective Female Hormone Mimics
    6. Life-Saving Dr. Mueller Selected To Get Top Sports Medicine Award
    7. Leader in cancer treatment and prevention research honored
    8. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
    9. Scientists to prototype cyberinfrastructure for research and education access to ocean observatories
    10. Belgian researchers explore revolutionary approach to angiogenesis
    11. Award winning researchers reveal potential new role for Glivec

    Post Your Comments:
    *Name:
    *Comment:
    *Email:


    (Date:8/14/2018)... LINDA, Calif. (PRWEB) , ... August 13, 2018 ... ... is valuable because it provides information on endogenous compounds produced in the body ... be recognized, be it from nutritional habits or physical activity. , By ...
    (Date:8/14/2018)... RESTON, Va. (PRWEB) , ... August 14, 2018 ... ... stigmas were recently depicted in the movie “Wonder,” to a better understanding of ... defects treatments, according to editors of the latest special issue of Birth ...
    (Date:8/7/2018)... ... 06, 2018 , ... Passersby can’t help but notice the ... Edwardsville’s University Park. SIUE students are working the “Feedstock Diversity Showcase” that features ... represent conventional biofuels production, advanced biofuels production and cellulosic biofuels production. , “This ...
    Breaking Biology News(10 mins):
    (Date:8/11/2018)... ... 10, 2018 , ... Researchers performing pressurized NMR or EPR experiments face a ... Chamber for High-Pressure NMR & EPR by Wilmad-LabGlass – SP Scienceware shields researchers ... , High-pressure experiments have significantly grown in popularity over the last several years. As ...
    (Date:8/9/2018)... ... August 09, 2018 , ... MedEvolve, Inc. , a ... analytics software and services for physician practices, announced today the company’s bookings for ... back-to-back record quarters in Q2 and Q3 last year, the company has exceeded ...
    (Date:8/1/2018)... (PRWEB) , ... August 01, ... ... healer, today announces research results on the significant impact of a proprietary ... responses. , The preclinical research assessed biomarkers for systemic and organ-specific ...
    (Date:7/26/2018)... ... July 26, 2018 , ... Ariadne ... of a biofield energy treated nutraceutical to improve anti-inflammatory and immune function responses. ... assessed in the preclinical research, were significantly reduced. Results are as follows:, ...
    Breaking Biology Technology:
    Cached News: