Selected estrogen compounds modify risks of vein clotting, a response to hormone replacement theraphy

PITTSBURGH, Pa. -- Hormone replacement therapy is prescribed in women for a number of reasons, including those undergoing menopause, partial or full hysterectomy, or amenorrhea. After menopause, conjugated estrogens, estradiol, or estrone sulfate are given to reduce pain during intercourse, limit blood vessel effects, and prevent loss of bone mass. After radical hysterectomy, conjugated estrogens are given for similar reasons. After menopause or partial hysterectomy, progestin is administered at the same time to offset an increased risk of endometrial cancer. In some amenorrheas, estrogen is given to restore menstrual cycle, and if therapy is unsuccessful, this may indicate the presence of pathology, for instance, pituitary tumor. Benefits for postmenopausal women include a lowered risk of heart attack (estrogen lowers LDL and raises HDL levels), and prevention of osteoporosis, since the rate of bone loss is directly linked to a drop in estrogen levels.

Despite the obvious benefits of this treatment, there is controversy regarding its application. Clinical trials indicate that the risk of venous thromboembolism (clotting of the veins) is about two to three times higher among current users of oral hormone replacement therapy containing estradiol, conjugated equine estrogen, and selective estrogen receptor modulators (SERMs) than among women who are not using hormone replacement therapy. (Conjugated equine estrogen (Premarin) contains 50-65 percent estrone sodium sulfate and 20-35 percent sodium equilin sulfate. Raloxifene is a synthetic estrogenic compound approved for clinical use in humans for prevention of osteoporosis.)

Many factors contribute to venous thrombosis including changes in the veins themselves, decreases in blood flow and increases in coagulation of the blood. Estrogen replacement drugs are known to alter coagulation, but little is known about affects on veins.

Veins are composed on a cell lining ca

Contact: Donna Krupa
American Physiological Society

Page: 1 2 3

Related biology news :

1. Life-Saving Dr. Mueller Selected To Get Top Sports Medicine Award
2. OHSU-VAMC study sheds light on estrogens benefit for MS
3. Ovarian cancer sheds tumor suppression with loss of estrogen receptor
4. Animal research suggests plant estrogens in soy do not increase breast cancer risk
5. Tamoxifen stimulates breast cancer growth following alteration of estrogen receptor
6. Soy processing influences estrogen-dependent breast cancer growth in mice
7. Exercise reduces blood estrogens, risk for breast cancer in post menopausal women
8. OHSU team discovers compound that lacks estrogens risks
9. Scientists uncover novel role for estrogen in bone marrow
10. Short-term exposure to estrogen cuts fish fertility
11. Scientists identify molecular link between estrogen receptors and invasive growth in breast cancer

Post Your Comments:

(Date:7/10/2020)... ... July 09, 2020 , ... Today CJ BIO announced the first in a ... the “fifth taste” phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor profiles ... on Monday, July 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a ... most common and aggressive adult brain cancer—announced today the appointments of its first ... charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows are ...
(Date:6/23/2020)... England (PRWEB) , ... June 23, 2020 , ... ... Africa supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and manufacturer of ... project to support testing operations in the fight against the COVID-19 pandemic in ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... , ... August 11, 2020 ... ... biopharmaceutical cold chain validation engineering firm, is making available for free its ... need to incorporate concurrent transport simulation testing into today’s biologics licensing application ...
(Date:8/3/2020)... ... August 03, 2020 , ... ... announced Jim Corrigan, President and CEO has been named one of the 100 ... of industry sectors, PharmaVoice 100 honorees are selected based on how they have ...
(Date:7/31/2020)... COLLEGE STATION, Texas (PRWEB) , ... July 29, ... ... pre-qualified cleanroom solutions today announced the launch of its new tagline, “BUILDING FOR ... within the biopharmaceutical industry and around the globe, requiring fast track capacity to ...
(Date:7/31/2020)... (PRWEB) , ... July 29, 2020 , ... ... and Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing ... announced that they have entered into a strategic partnership whereby Catalent will provide ...
Breaking Biology Technology:
Cached News: