Sensor uses DNA to detect presence of lead, a dangerous c...( selected has a single strand that can w...)

Sensor uses DNA to detect presence of lead, a dangerous contaminant

selected has a single strand that can wrap around like a protein. In that single strand, the researchers fashion a specific binding site a kind of pocket that can only accommodate the metal ion of choice.

The principles demonstrated in this work can also be used to obtain DNA biosensors for other metal ions that are toxic (such as mercury and cadmium) or beneficial (such as calcium and potassium) to humans, Lu said. At the same time, we can offer insight into both the sequence and structure of DNA that is responsible for the metal specificity.

Lu and Li described their catalytic DNA sensor in the Oct. 25 issue of the Journal of the American Chemical Society. Funding was provided by the National Institutes of Health. The researchers have applied for a patent.

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Contact: James E. Kloeppel, Physical Sciences Editor
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
2-Nov-2000

Page: 1 2
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