HOME >> BIOLOGY >> NEWS
Separated before birth: Molecular signals part fetal blood and lymphatic vessels

(Philadelphia, PA) At some point in fetal development, cells from the newly emerged blood circulatory system start out on their own and form a separate parallel network of vessels known as the lymphatic system. In the January 10th issue of Science, researchers from the University of Pennsylvania School of Medicine report the discovery of the molecular signals necessary to separate the lymph vessel network from the blood vessel network.

Their findings clarify an important juncture in fetal development, shed light on the mechanisms by which molecular signals influence vascular development, pave the way for potential therapeutics, and may ultimately clear up a minor mystery among researchers that has been brewing since the mid-1990s.

"According to our studies, the SLP-76 and Syk proteins, which we previously knew to have a signaling function in white blood cell development, are absolutely critical in separating the lymphatic system from the circulatory system," said Gary Koretzky, MD, PhD, professor in Penn's Department of Pathology and Laboratory Medicine and director of the Signal Transduction Program at the Abramson Family Cancer Research Institute. "This new role is important if we are ever to learn how to influence the growth of blood or lymphatic vessels.

For example, under some clinical circumstances, it would be useful to encourage the growth of new blood vessels or, conversely, discourage new vessels from supplying blood to growing tumors."

Since the mid-1990s, researchers have been trying to determine the exact function of SLP-76 and Syk. The proteins are related signals involved in hematopoiesis the process by which stem cells transform into red and white blood cells. To better understand the function of these signals, several groups created animal models that lacked SLP-76 or Syk in order to see what happens in their absence. Researchers in Koretzky's laboratory found that most animal models lacking SLP-76 had severe abnormalities
'"/>

Contact: Greg Lester
lesterg@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
10-Jan-2003


Page: 1 2 3

Related biology news :

1. Counting foxes before the last tally-ho
2. Study finds anti-HIV protein evolved millions of years before the emergence of AIDS
3. What are babies thinking before they start talking?
4. Can exercise before diving prevent decompression sickness?
5. Genetic info of cloned pigs may help babies before birth
6. Chromosomes are nibbled before they fuse, researchers report
7. Stop to smell the flowers - But do it before theyre pollinated
8. Ethical guidelines needed before nutrigenomic groceries come to market
9. Scientists, physicians discuss latest discoveries for stopping cancer before it starts
10. Researchers show autoantibodies occur before lupus in New England Journal of Medicine
11. New research challenges advice that men should abstain from sex before fertility treatment

Post Your Comments:
(Date:3/24/2015)... GARDENS, Fla. , March 24, 2015 /PRNewswire/ ... identity management solutions, today announced that its U.are.U ... clothing accessory retailer Goorin Bros . to ... Crossmatch biometrics-based solution secures access to the POS ... the increased risk of data breaches. ...
(Date:3/20/2015)... DUBLIN , Mar. 20, 2015 Research ... announced the addition of the "India Sensors ... their offering. The sensor market is ... through 2020 Consumer electronics, automotive, industrial ... for sensors in the country. In addition, adoption ...
(Date:3/18/2015)... As mobile payments become more prevalent ... and apps continue to be introduced into the market place ... payment industry in focus today are:  NXT-ID, Inc. (NASDAQ: ... BABA ), Apple Inc. (NASDAQ: AAPL ), Google ... FB ) NXT-ID, Inc. (NASDAQ: ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
(Date:3/26/2015)... "In America," the popular news television program that airs in ... legendary film actor James Earl Jones, has announced that it ... , Botany is commonly described as the scientific study ... bit more complicated than that. Scientists and other professionals study ... the smallest bacteria known to man to the largest trees ...
(Date:3/25/2015)... 26, 2015 Agnition announced today that ... American Farmer, airing for the first time at 7:30 ... American Farmer will explore the extremely important role soil ... with a patented Microbial Catalystâ„¢ technology that enhances soil ... The segment will air again on April 28. , ...
(Date:3/25/2015)... , March 25, 2015  S&P Capital ... Factual Stock Report coverage on Abattis Bioceuticals ... ATTBF; CSE: ATT): is a specialty biotechnology company ... cultivating, licensing and marketing proprietary ingredients, bio-similar compounds, ... in North America . The ...
(Date:3/25/2015)... (PRWEB) March 25, 2015 An increase ... ingredients in all forms of food nutrients, regulatory changes ... a substantial rise in demand for natural astaxanthin over ... started to ramp up their capacities to satisfy the ... natural and synthetic source astaxanthin (used in nutraceuticals, aqua ...
Breaking Biology Technology:Agnition to be Featured In Upcoming Episode of American Farmer on RFD-TV 2S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 5Global Astaxanthin Market to Reach Value of USD 1.1 billion by 2020, Expects Industry Experts in New Report Available at MarketPublishers.com 2
Cached News: