HOME >> BIOLOGY >> NEWS
Separated before birth: Molecular signals part fetal blood and lymphatic vessels

(Philadelphia, PA) At some point in fetal development, cells from the newly emerged blood circulatory system start out on their own and form a separate parallel network of vessels known as the lymphatic system. In the January 10th issue of Science, researchers from the University of Pennsylvania School of Medicine report the discovery of the molecular signals necessary to separate the lymph vessel network from the blood vessel network.

Their findings clarify an important juncture in fetal development, shed light on the mechanisms by which molecular signals influence vascular development, pave the way for potential therapeutics, and may ultimately clear up a minor mystery among researchers that has been brewing since the mid-1990s.

"According to our studies, the SLP-76 and Syk proteins, which we previously knew to have a signaling function in white blood cell development, are absolutely critical in separating the lymphatic system from the circulatory system," said Gary Koretzky, MD, PhD, professor in Penn's Department of Pathology and Laboratory Medicine and director of the Signal Transduction Program at the Abramson Family Cancer Research Institute. "This new role is important if we are ever to learn how to influence the growth of blood or lymphatic vessels.

For example, under some clinical circumstances, it would be useful to encourage the growth of new blood vessels or, conversely, discourage new vessels from supplying blood to growing tumors."

Since the mid-1990s, researchers have been trying to determine the exact function of SLP-76 and Syk. The proteins are related signals involved in hematopoiesis the process by which stem cells transform into red and white blood cells. To better understand the function of these signals, several groups created animal models that lacked SLP-76 or Syk in order to see what happens in their absence. Researchers in Koretzky's laboratory found that most animal models lacking SLP-76 had severe abnormalities
'"/>

Contact: Greg Lester
lesterg@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
10-Jan-2003


Page: 1 2 3

Related biology news :

1. Counting foxes before the last tally-ho
2. Study finds anti-HIV protein evolved millions of years before the emergence of AIDS
3. What are babies thinking before they start talking?
4. Can exercise before diving prevent decompression sickness?
5. Genetic info of cloned pigs may help babies before birth
6. Chromosomes are nibbled before they fuse, researchers report
7. Stop to smell the flowers - But do it before theyre pollinated
8. Ethical guidelines needed before nutrigenomic groceries come to market
9. Scientists, physicians discuss latest discoveries for stopping cancer before it starts
10. Researchers show autoantibodies occur before lupus in New England Journal of Medicine
11. New research challenges advice that men should abstain from sex before fertility treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/3/2016)... DE SOTO, Kansas , March 3, 2016 ... to offer Oncimmune,s Early CDT®-Lung, a blood test ... of lung cancer Early CDT®-Lung test to ... --> Early CDT®-Lung test to its clients ... Oncimmune, a leader in early cancer detection, today ...
(Date:3/2/2016)... , March 2, 2016 ... of the "Global Biometrics as a ... offering. --> http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) ... "Global Biometrics as a Service Market 2016-2020" ... --> Research and Markets ( http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ...
(Date:3/1/2016)... March 1, 2016  (RSAC Booth #3041) – True ... whopping $118 billion is lost to false positives, where ... inaccurate fraud detection. At the RSA Conference 2016, NuData ... companies handle authentication by devaluing the data fraudsters have ... --> --> ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... ... April 28, 2016 , ... ... deliver a talk on its first-in-class technologies for tissue stem cell counting and ... on RNAiMicroRNA Biology to Reprogramming & CRISPR-based Genome Engineering in Burlington, Massachusetts. , ...
(Date:4/27/2016)... ... 2016 , ... Cambridge Semantics, the leading provider of Smart Data ... has been named to The Silicon Review’s “20 Fastest Growing Big Data Companies of ... serves the needs of end users facing some of the most complex data challenges ...
(Date:4/27/2016)... New York, NY (PRWEB) , ... April 27, ... ... without realizing it. Touch screen mobile devices with fingerprint recognition for secure ... image libraries are only a few ways consumers are interacting with biometrics technology ...
(Date:4/27/2016)... ... April 27, 2016 , ... The Board ... the appointment of John Tilton as Chief Commercial Officer.  Mr. Tilton joined Biohaven ... the founding commercial leaders responsible for the commercialization of multiple orphan drug indications. ...
Breaking Biology Technology:
Cached News: