HOME >> BIOLOGY >> NEWS
Separated before birth: Molecular signals part fetal blood and lymphatic vessels

(Philadelphia, PA) At some point in fetal development, cells from the newly emerged blood circulatory system start out on their own and form a separate parallel network of vessels known as the lymphatic system. In the January 10th issue of Science, researchers from the University of Pennsylvania School of Medicine report the discovery of the molecular signals necessary to separate the lymph vessel network from the blood vessel network.

Their findings clarify an important juncture in fetal development, shed light on the mechanisms by which molecular signals influence vascular development, pave the way for potential therapeutics, and may ultimately clear up a minor mystery among researchers that has been brewing since the mid-1990s.

"According to our studies, the SLP-76 and Syk proteins, which we previously knew to have a signaling function in white blood cell development, are absolutely critical in separating the lymphatic system from the circulatory system," said Gary Koretzky, MD, PhD, professor in Penn's Department of Pathology and Laboratory Medicine and director of the Signal Transduction Program at the Abramson Family Cancer Research Institute. "This new role is important if we are ever to learn how to influence the growth of blood or lymphatic vessels.

For example, under some clinical circumstances, it would be useful to encourage the growth of new blood vessels or, conversely, discourage new vessels from supplying blood to growing tumors."

Since the mid-1990s, researchers have been trying to determine the exact function of SLP-76 and Syk. The proteins are related signals involved in hematopoiesis the process by which stem cells transform into red and white blood cells. To better understand the function of these signals, several groups created animal models that lacked SLP-76 or Syk in order to see what happens in their absence. Researchers in Koretzky's laboratory found that most animal models lacking SLP-76 had severe abnormalities
'"/>

Contact: Greg Lester
lesterg@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
10-Jan-2003


Page: 1 2 3

Related biology news :

1. Counting foxes before the last tally-ho
2. Study finds anti-HIV protein evolved millions of years before the emergence of AIDS
3. What are babies thinking before they start talking?
4. Can exercise before diving prevent decompression sickness?
5. Genetic info of cloned pigs may help babies before birth
6. Chromosomes are nibbled before they fuse, researchers report
7. Stop to smell the flowers - But do it before theyre pollinated
8. Ethical guidelines needed before nutrigenomic groceries come to market
9. Scientists, physicians discuss latest discoveries for stopping cancer before it starts
10. Researchers show autoantibodies occur before lupus in New England Journal of Medicine
11. New research challenges advice that men should abstain from sex before fertility treatment

Post Your Comments:
(Date:10/15/2014)... , Oct. 15, 2014 Sandata Technologies, ... home and community-based care, today announced it released ... Sandata,s Santrax® Electronic Visit Verification™ Solution (EVV™)  for ... a home health company founded in 1996 and ... . The study details the ...
(Date:10/15/2014)... pneumonia in female mice to an enzyme activated by ... more resistant to respiratory infections than males. Now, an ... to bacterial pneumonia in female mice is linked to ... show that this enzyme is ultimately activated by the ... team, lead by Professor Lester Kobzik at the Harvard ...
(Date:10/14/2014)... in Cancer Research shows SIRT6—a protein known ... promote the development of skin cancers by turning on ... sun-damaged skin cells. , Previously considered protective, SIRT6 is ... that help regulate genomic stability and prevent some of ... DNA damage, which can lead to cancer. This study, ...
Breaking Biology News(10 mins):Sandata Announces Case Study with Quality Care Services, Inc. 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
(Date:10/22/2014)...   Synthetic Biologics, Inc. (NYSE MKT: SYN), ... infections and diseases, announced today that the U.S. Patent ... for a composition of matter patent application that covers ... SYN-004. This is Synthetic Biologics, first allowed patent application ... to the Company,s extensive C. difficile patent ...
(Date:10/22/2014)... Research and Markets  has announced the addition of ... Geography - Global Analysis and Forecast (2014 - 2020)" ... electronics, also called as polymer electronics or plastic electronics, ... small conductive molecules and electrically conductive polymers. It is ... carbon based, made using synthetic strategies developed in the ...
(Date:10/20/2014)... Mapp Biopharmaceutical,s valiant effort to produce ... fight the Ebola outbreak will make the public ... of pharmaceuticals can be, according to Kalorama Information.  ... some may be taken aback by the three-month ... knowledge are well aware of the complex issues ...
(Date:10/20/2014)... 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the ... Q3 orders to $5.8 million and provides a good start to ... North America and one in the ... projects at record levels," said Peter Bruijns , President & ... end of Q3 than they have been for any complete year ...
Breaking Biology Technology:Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3
Cached News: