Sepsis drug fights infection, decreases hospital care over two year study

A study in the July 15 issue of the journal "Clinical Infectious Diseases" shows that people 75 and older who were treated for severe sepsis with the drug drotrecogin alpha activated (DAA) had markedly higher survival rates, spent less time on ventilators and in intensive care units and had no more risk of side effects than their younger counterparts -- patients 65 to 74 -- treated with the same drug.

Unfortunately, the study author, Dr. Wes Ely of Vanderbilt University Medical Center, says the drug is highly underutilized. "Conservatively, I would say that fewer than one in four of the older patients who are candidates for this potentially life-saving drug actually receive it," said Ely, associate professor of allergy, pulmonary and critical care medicine and the director of research for the Geriatric Research Education and Clinical Center (GRECC) for the VA Tennessee Valley Health Care System.

The study raises concerns about an age bias in medicine. "The medical community as a whole hasn't fully embraced this type of medical therapy for severe sepsis because of concerns about resource use and safety in older patients and questions about their subsequent quality of life," Ely said. "On one hand some older patients receive overly aggressive life support without benefit, but in the case of this new drug, physicians seem to practice ageism and don't use the available therapy to patients' full advantage.

"When patients are relatively healthy and active, we should take age out of the medical equation. Older patients need research specific to their outcomes and they need advocates," he said.

More than 2,000 people are diagnosed with severe sepsis every day, and this disease kills as many people as heart attacks -- 750 each day in the United States.. The problem continues to grow as the population ages. More than half of all ICU days are occupied by people 65 and older; the number of days per year spent in an ICU are seven-times greater for people

Contact: Clinton Colmenares
Vanderbilt University Medical Center

Page: 1 2 3

Related biology news :

1. UGA receives $6.7 M grant that will add knowledge in fights against cancer, Parkinsons disease
2. Protein that fights bacteria and viruses cloned by Scripps scientists
3. Study of monkey species that fights off AIDS may lead to new treatments for humans
4. Six-week, six-shot regimen fights hayfever for more than one season
5. New drug lead fights bacteria that can be lethal by disrupting quorum sensing and biofilms
6. Bacterias natural foe fights drug-resistant infections
7. Tea fights cavities, reduces plaque
8. Genetically engineered poliovirus fights brain tumors
9. Decoy molecule that fights food poisoning might help defeat other toxins
10. Fat switch fights flab at the cellular level, Science authors report
11. After natural disasters, the risk of infection, epidemics from dead bodies is negligible

Post Your Comments:

(Date:8/26/2020)... (PRWEB) , ... August 25, ... ... clinical-stage biotechnology company developing novel pharmaceuticals targeting mitochondria, in partnership with Essex ... enrolment in its pivotal U.S. Phase 3 VISTA-2 study of SkQ1 ophthalmic ...
(Date:8/21/2020)... , ... August 19, 2020 , ... ... LLC and SalivaBio LLC, businesses dedicated to Salivary Bioscience for more than twenty ... recently published book by Springer, " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research ...
(Date:8/7/2020)... ... August 06, 2020 , ... ... pleased to announce that Eric Chen and Jessica Wong have joined the company’s ... & Strategy, respectively. , Eric Chen heads development efforts for Alucio’s flagship product, ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management ... reasons it did not take off as quickly as people initially expected, and where ... towards capturing data electronically for clinical trials and then repurposing it for downstream analysis, ...
(Date:7/22/2020)... ... , ... Join experts from Reed Tech , Gary Saner, Sr. Manager, ... hour live webinar on Thursday, August 13, 2020 at 11am EDT (4pm ... devices. Specifically, for medical devices, the NMPA has departments dealing with medical device registration ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... in the early detection and prevention of high-burden diseases, and Centric Consulting, a ... and healthcare organizations to utilize existing data in order to identify and prioritize ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... of Technology (MIT) has expanded the company’s exclusive license to include clinical ... the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. CANARY’s™ ...
Breaking Biology Technology:
Cached News: