HOME >> BIOLOGY >> NEWS
Sequenced malaria genome exposes novel drug targets

The genetic code of the malaria parasite has been cracked and is already revealing novel drug targets that could lead to effective treatment of the disease.

An international effort was launched in 1996 to sequence the genome of the most deadly malaria species, Plasmodium falciparum. Botanists from the University of Melbourne are now leading the charge to help find safe and effective anti-malarial drugs.

Professor Geoff McFadden and his team from the University of Melbourne recently discovered that the malaria parasite evolved from a plant-like organism that survived by photosynthesis. It is this plant-like part that, so far, appears to be a depot for anti-malarial drug targets. Consequently, existing safe herbicides are providing leads for some of these new drugs. So too are antibiotics.

"Our role in this international collaboration is to find the genes associated with the relict plant component of the parasite. This has been a key success of the study. At least 12 new drug targets have been identified so far from the plant-like genes" says McFadden.

The collaboration's research, including the complete sequence of the malaria parasite, is published in the latest edition of the prestigious journal Nature.

Human malaria is caused by infection with parasites of the Plasmodium species that are transmitted by Anopheles mosquitoes.

Plasmodium species are members of large group numbering over 5000 species that harbour a relict chloroplast, the part of a plant that carries out photosynthesis. Scientists have determined this relict, called the apicoplast, is essential for the malaria parasite's survival, but its exact role is unclear.

McFadden's team has gone someway to unraveling the apicoplast's mysteries. They have revealed that it is the apicoplast that houses the herbicide-sensitive pathways and compounds with potential for drug therapy. Stuart Ralph, a PhD student in McFadden's lab, has helped identify th
'"/>

Contact: Jason Major
jmajor@unimelb.edu.au
61-3-8344-0181
University of Melbourne
3-Oct-2002


Page: 1 2 3

Related biology news :

1. Master of antimalarial resistance
2. Improved nutrition could reduce malaria burden worldwide
3. Antimalarial substances found in New Caledonian sponges
4. Inadequate vaccines can help breed more vicious malaria strains
5. Discovery in parasite movement may offer insights into malaria
6. Plant-like enzyme acts as key life cycle switch in malaria parasite
7. First target for childhood malaria vaccine
8. GenVec, U.S. NMRC, and PATHs Malaria Vaccine Initiative partner to expand malaria vaccine efforts
9. Mosquitoes vs. malaria: How we can win the fight
10. New, non-radioactive screen for antimalarial compounds
11. New advance to combat antibiotic-resistant pneumonia and malaria

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/22/2019)... ... February 20, 2019 , ... RoosterBio, Inc, ... expand the company’s footprint in Frederick, MD after a year of rapid growth. ... human mesenchymal stem/stromal cell (hMSCs) products to streamline their product development efforts in ...
(Date:2/22/2019)... , ... February 21, 2019 , ... ... (Fuzionaire Dx) have executed a research agreement establishing a collaborative program to work ... will be to develop new radiopharmaceutical lead candidates and will explore Fuzionaire Dx’s ...
(Date:2/14/2019)... ... February 14, 2019 , ... This year’s conference in ... 80 scientific sessions and 2,100 presentations. Given SOT’s mission to bring together researchers ... OpenLiver™ 3D cell culture model initiative that it recently launched with Biopredic ...
Breaking Biology News(10 mins):
(Date:3/4/2019)... (PRWEB) , ... March 04, 2019 , ... Stay on top of current hot topics ... Access to all webinars is free, so be sure to register today to save your ... to see our upcoming webinars: , CLINICAL TRIALS, , March ...
(Date:2/27/2019)... ... February 26, 2019 , ... Superior Controls, Inc., a ... with 140 employees on both the east and west coasts, today announced that ... of New Hampshire. Sandmaier, a senior project engineer, joins Taggart McCormick, P.E., Anthony ...
(Date:2/22/2019)... MURRIETA, Calif. (PRWEB) , ... February 20, 2019 ... ... incubator and SeqOnce , an emerging leader in the rapidly growing NGS ... sample solutions for the Murrieta Genomics laboratory and incubator. , "As an innovation ...
(Date:2/22/2019)... ... February 20, 2019 , ... ... to Novel Captcha Systems. , The patents in lot 92 ... and tests are used to distinguish between human users and computers through exploiting ...
Breaking Biology Technology:
Cached News: