HOME >> BIOLOGY >> NEWS
Sequencing project results in six-fold reduction of effective size of maize genome

A team of scientists that includes a Washington University in St. Louis biologist, has evaluated and validated a gene-enrichment strategy for genome sequencing and has reported a major advance in sequencing large genomes. The team showed a six-fold reduction of the effective size of the Zea mays (maize or corn) genome while creating a four-fold increase in the gene identification rate when compared to standard whole-genome sequencing methods.

The Maize Genomics Consortium reported their results in the December 19, 2003 issue of Science magazine. Karel R. Schubert, Ph.D., Washington University affiliate professor of biology in Arts & Sciences, was the principal investigator of the study. Schubert is vice president of technology management and science administration at the Donald Danforth Plant Science Center in St. Louis.

The Maize Genomics Consortium, consisting of The Donald Danforth Plant Science Center, The Institute for Genomic Research (TIGR), Purdue University, and Orion Genomics, was awarded a two-year, $6 million plant genome grant on September 20, 2002 by the National Science Foundation (NSF) to develop and evaluate high-throughput and robust strategies to isolate and sequence maize genes. The two gene-enrichment methods used in the research published in Science are methyl-filtration and high-Cot selection.

According to Schubert and W. Brad Barbazuk, Ph.D., senior bioinformatics specialist and assistant domain member, both at the Donald Danforth Plant Science Center, the overall goal of the pilot sequencing project in maize is to derive an effective strategy to sequence the maize genome. To meet this goal, the Maize Genomics Consortium will generate approximately 800,000 total sequence reads using the methyl-filtration and high-Cot methods, with the results published in Science describing the analysis of the first 200,000 sequence reads.

It is a challenging effort to sequence the maize genome, as its size and structure preclude
'"/>

Contact: Tony Fitzpatrick
tony_fitzpatrick@wustl.edu
314-935-5272
Washington University in St. Louis
8-Mar-2004


Page: 1 2

Related biology news :

1. NSF awards $4.3 million to Rutgers for Maize Genome Sequencing Project
2. Sequencing the human genome: unraveling the mysteries of health and disease
3. Artificial Gels Could Speed DNA Sequencing
4. Whitehead Receives $7 million NIH Grant To Build High-Speed Sequencing Machines
5. Hopkins Scientists Sequencing Of AIDS Virus From India Waves A Red Flag For Vaccine Developers
6. DOE Joint Human Genome Effort Exceeds Sequencing Goal
7. Sequencing Milestone Reached By DOE Joint Genome Institute
8. Harvard Medical School Researchers Present Atomic Structure Of DNA-Replicating Enzyme Widely Used In DNA Sequencing
9. NSF awards 22 new projects for plant genome research
10. NSF and AIBS sign cooperative agreement for NEON project office
11. Hardy buoys: Texas A&M project predicts oil spill movements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2019)... N.J. (PRWEB) , ... February ... ... the leading global provider of advanced delivery technologies and development solutions for ... The Procter & Gamble Company’s (P&G) highest external business partner recognition, the ...
(Date:2/13/2019)... ... February 13, 2019 , ... ... Medication Distribution System. It features Wi-Fi enabled RFID Locks that provide healthcare facilities ... a live audit trail on the network for superior access control and shrinkage ...
(Date:2/11/2019)... (PRWEB) , ... February 11, 2019 , ... ... DNA analysis products and services, announced a new forensic genealogy service offering to ... combines advanced DNA testing and genealogy to develop ancestral relationships between samples ...
Breaking Biology News(10 mins):
(Date:3/14/2019)... ... March 14, 2019 , ... EyeCRO LLC has ... OK. EyeCRO joins the Department of Veterans Affairs, the Oklahoma Medical Research Foundation, ... fifth institution in Oklahoma to receive this prestigious endorsement. The award letter ...
(Date:3/14/2019)... MURRIETA, Calif. (PRWEB) , ... March 13, 2019 , ... ... Advisory Board. The Board will bring industry specific and broader business experience to bear ... the incubator to have access to the knowledge and expertise that our Advisory Board ...
(Date:3/12/2019)... and LIÈGE, Belgium (PRWEB) , ... March 12, ... ... solutions for sample preparation and epigenetics research, has launched its third generation long-fragment ... of the second generation instrument with a user-friendly interface, automated processing, and ...
(Date:3/9/2019)... ... March 08, 2019 , ... ... education planning, announced the release of their Best Online Master's in Biotechnology ... based on curriculum quality, program flexibility, affordability, and graduate outcomes. , In ...
Breaking Biology Technology:
Cached News: