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Serotonin May Be Better Target For Attention Deficit Hyperactivity Disorder Treatment

er balance between dopamine and serotonin are key," says Raul Gainetdinov, a member of Caron's research team. "Hyperactivity may develop when the relationship between dopamine and serotonin is thrown off balance."

The brain has 15 types of receptors that bind to serotonin, and Gainetdinov is now trying to determine which specific serotonin receptors mediate the effects of Ritalin®.

The hope, says Caron, "is that we can replace Ritalin® with a very specific compound that targets a single subset of receptors." While Prozac® calmed hyperactivity in the knockout mice, Gainetdinov says that "Prozac® isn't the best, because it isn't very selective." Caron and Gainetdinov are optimistic that a new generation of compounds that interact more specifically with the serotonin system will prove to be safer and more effective for treatments for ADHD.


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Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
14-Jan-1999


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