HOME >> BIOLOGY >> NEWS
Serotonin metabolites in mollusks suggest pathways for human therapies

CHAMPAIGN, Ill. -- From mollusks to mammals, newly discovered chemical pathways of serotonin in the nervous system are paving a path toward future pharmaceutical treatments for depression and other disorders.

"Understanding novel serotonin pathways in a tissue-dependent manner is useful for the development of pharmaceuticals intended to preserve serotonergic signaling," said Jeffrey N. Stuart, a doctoral student in the department of chemistry at the University of Illinois at Urbana-Champaign.

Recent findings by Stuart and his Illinois colleagues were the topic of a talk, "Characterization of Novel Serotonin Biochemical Pathways for Potential Therapeutic Applications," last month at the American Chemical Society's 228th National Meeting in Philadelphia and of a paper in the August issue of the Journal of Neurochemistry.

Serotonin (5-hydroxytryptamine, or 5-HT) is a neurotransmitter present throughout the body. When nerve cells containing it are activated, serotonin is released. It travels and stimulates other nerve cells, enabling their message to spread through the nervous system.

"When serotonin is released, you do not want its signal to last forever," said Jonathan Sweedler, professor of chemistry and Stuart's academic adviser. The signal caused by serotonin is turned off by enzymes that inactivate it by converting it into various metabolites, such as the ones discovered by Stuart.

Disruptions of serotonin signaling pathways are thought to occur in disorders such as depression, anxiety, sudden infant death syndrome, attention deficit hyperactivity disorder and irritable bowel syndrome. Many pharmaceutical treatments restore the pathways by preventing the cellular uptake of serotonin, where it is converted to other metabolites, or by directly inhibiting the enzymes responsible for the molecular conversion.

Because serotonin is distributed throughout the body, pharmaceuticals intended to correct serotonin im
'"/>

Contact: Molly McElroy, News Bureau
jebarlow@uiuc.edu
217-333-5802
University of Illinois at Urbana-Champaign
9-Sep-2004


Page: 1 2 3

Related biology news :

1. Serotonin May Be Better Target For Attention Deficit Hyperactivity Disorder Treatment
2. Genetically Engineered Mice Exhibit Anxiety, Offering Insight Into Role Of Serotonin In Brain
3. Marine Snail Toxin Targeted At African Toad Eggs Reveals Novel Impact On The Regulation Of Serotonin
4. Laser Microscope At Cornell Images Serotonin In Live Cells
5. Researchers find two metabolites of gasoline additives in humans
6. Report in BioScience details global decline of nonmarine mollusks
7. Discovery of fossil mollusks in Alaska links histories of Arctic Ocean and Isthmus of Panama
8. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
9. Research suggests new avenue for stopping, preventing colon cancer
10. New sign language suggests children create languages fundamentals through learning
11. Images of tail of protein needed for cell multiplication suggest anticancer drug targets

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... company announced a new partnership with medical equipment manufacturer, Spectrum Solutions, to provide ... clients to strengthen their laboratory supply chain for more than 10 years. Early ...
(Date:7/18/2020)... SAN ANTONIO (PRWEB) , ... July 16, 2020 ... ... PLOS ONE that demonstrates the effectiveness of the Invictus Medical Neoasis™ active noise ... (NICU) environment. The study reported that the Neoasis™ device attenuated the alarm sounds ...
(Date:7/4/2020)... ... July 03, 2020 , ... Aesthetics Biomedical ... and multiple awards for not only the products and treatments developed, but also ... Vivace® Microneedle RF. All the brands built by ABM have received several honors ...
Breaking Biology News(10 mins):
(Date:8/7/2020)... ... August 06, 2020 , ... VGXI, a ... has closed on the purchase of greenfield for a new, expanded manufacturing facility. ... over 21 acres in the initial acquisition, with an option to purchase an ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, ... its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at ... requiring fast track capacity to provide patients with urgently needed vaccines and other ...
(Date:7/31/2020)... TORONTO (PRWEB) , ... July 29, 2020 , ... eSource ... and inefficiencies. This webinar will cover the history of eSource, the reasons it did ... From EMR/EHR to wearables, to site source, the industry is moving towards capturing data ...
(Date:7/18/2020)... , ... July 16, 2020 , ... After research model ... completion of a great surgery is only the beginning of a successful study, while ... community. , Join Brad Gien, Global Head of Surgery from Envigo in ...
Breaking Biology Technology:
Cached News: