HOME >> BIOLOGY >> NEWS
Severe Pain Following Shingles Safely Relieved In Clinical Trial Of Anti-Convulsant Drug Gabapentin

In a clinical trial of a new type of drug to relieve severe, chronic pain caused by nerve damage, the anti-convulsant medicine gabapentin has provided significant relief from the aching, burning, tearing pain that some shingles patients suffer for years after other symptoms subside.

Shingles, caused by the virus Herpes zoster, results from the reactivation of the chickenpox virus and attacks more than a million people in the United States each year. While the shingles rash and pain eventually subside in most people, about 10 to 15 percent experience continued severe pain known as postherpetic neuralgia, or PHN, which can last years, and often the rest of an older patient's life.

The shingles clinical trial was reported in the December 2 issue of the Journal of the American Medical Association (JAMA) by University of California San Francisco neurologist Michael Rowbotham, MD, and colleagues at the Rehabilitation Institute of Chicago, Oregon Health Sciences University, and Parke-Davis Pharmaceutical Research, which funded the study.

Soon after gabapentin came into use in 1995 to treat epilepsy, physicians noted its pain-relieving powers. The shingles study reported in the Dec. 2 issue of JAMA is one of two multi-center studies to test the drug's ability to control severe pain associated with nerve damage. A report on its ability to relieve pain from diabetic neuropathy is also published in the Dec. 2 JAMA issue. An editorial on the promising findings, written by Mayo Clinic neurologist Phillip Low, appears in the same issue.

Tricyclic antidepressants are the principal drug used to treat PHN pain, but they don't work for more than half of those who try them, and many cannot tolerate their side effects, which include decreased blood pressure, constipation and forgetfulness, Rowbotham said. Most PHN sufferers are elderly, making these side effects particularly unacceptable. In contrast, gabapentin appears to be at least as
'"/>

Contact: Wallace Ravven
415-502-1332
University of California - San Francisco
1-Dec-1998


Page: 1 2 3

Related biology news :

1. Severe depression associated with greater number of nerve cells in thalamus region of brain
2. Severe kidney disease in blacks linked to genes on two chromosomes
3. Scientists Find Gene For Severe Form Of Epilepsy
4. Severe Falciparum Malaria Increases In Honduras
5. Common Anti-Viral Medication Prevents Severe Eye Herpes
6. Common Food Dye Can Cause Severe Allergic Reactions
7. Oral Vaccine Protects Infants From Severe Rotavirus Diarrhea
8. Following complex motions
9. Study Suggests Vaccine Increases Survival In Ovarian And Breast Cancer Patients Following High-Dose Chemotherapy And Autologous Stem Cell Transplant
10. Spraying Water Containing Airborne Bacteria Found At Some Indoor Swimming PoolsCan Cause "Lifeguard Lung" Following Long-Term Exposure
11. High Temperature Immediately Following A Stroke Leads To Worse Outcome; Quick Cooling Shown To Have Benefit

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... ... instrumentation, is pleased to announce the next event in a series of TOPIQ ... , The TOPIQ series of webinars was developed in response to social distancing ...
(Date:6/13/2020)... , ... June 11, 2020 , ... ... services, announces a significant expansion of its forensic genealogy team. Bode’s Forensic ... attorneys through proven forensic genealogy and DNA analysis methods. The team has added ...
(Date:6/5/2020)... ... ... Greffex, a pioneering vaccine and gene therapy company based in Houston, Texas, welcomes Mr. ... global perspective to make an impact in a post pandemic world,” said Co-Chairman John ... director of the company. , “The Greffex board is excited to have Neil as ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... ... ... This new service offers clients a way to speak with Subject Matter ... need arises. Lachman’s OnCall SMEs have extensive knowledge of a wide range of scientific, ... SMEs are available normal business hours Monday through Friday from 9:00 am – 5:00 ...
(Date:5/14/2020)... ... May 12, 2020 , ... DuPont Nutrition ... distribution partner for all personal care ingredients in Russia and Belarus. Beginning May ... preservative portfolio for personal care. , The GENENCARE®OSMS product line contains ...
(Date:5/14/2020)... (PRWEB) , ... May 13, 2020 , ... ... hub called Future Lab: Optimizing Workflows in the Life Science Lab . ... workflows in their lab, from water purification and liquid handling to contamination control. ...
(Date:5/9/2020)... ... , ... Worldwide Business with kathy ireland® will be LIVE ... 2020 and Wednesday, May 13, 2020 at 8:00pm ET / PT – prime ... from Techolution and Bravado Pharmaceuticals . , As leaders in ...
Breaking Biology Technology:
Cached News: