Severe Pain Following Shingles Safely Relieved In Clinical Trial Of Anti-Convulsant Drug Gabapentin

In a clinical trial of a new type of drug to relieve severe, chronic pain caused by nerve damage, the anti-convulsant medicine gabapentin has provided significant relief from the aching, burning, tearing pain that some shingles patients suffer for years after other symptoms subside.

Shingles, caused by the virus Herpes zoster, results from the reactivation of the chickenpox virus and attacks more than a million people in the United States each year. While the shingles rash and pain eventually subside in most people, about 10 to 15 percent experience continued severe pain known as postherpetic neuralgia, or PHN, which can last years, and often the rest of an older patient's life.

The shingles clinical trial was reported in the December 2 issue of the Journal of the American Medical Association (JAMA) by University of California San Francisco neurologist Michael Rowbotham, MD, and colleagues at the Rehabilitation Institute of Chicago, Oregon Health Sciences University, and Parke-Davis Pharmaceutical Research, which funded the study.

Soon after gabapentin came into use in 1995 to treat epilepsy, physicians noted its pain-relieving powers. The shingles study reported in the Dec. 2 issue of JAMA is one of two multi-center studies to test the drug's ability to control severe pain associated with nerve damage. A report on its ability to relieve pain from diabetic neuropathy is also published in the Dec. 2 JAMA issue. An editorial on the promising findings, written by Mayo Clinic neurologist Phillip Low, appears in the same issue.

Tricyclic antidepressants are the principal drug used to treat PHN pain, but they don't work for more than half of those who try them, and many cannot tolerate their side effects, which include decreased blood pressure, constipation and forgetfulness, Rowbotham said. Most PHN sufferers are elderly, making these side effects particularly unacceptable. In contrast, gabapentin appears to be at least as

Contact: Wallace Ravven
University of California - San Francisco

Page: 1 2 3

Related biology news :

1. Severe depression associated with greater number of nerve cells in thalamus region of brain
2. Severe kidney disease in blacks linked to genes on two chromosomes
3. Scientists Find Gene For Severe Form Of Epilepsy
4. Severe Falciparum Malaria Increases In Honduras
5. Common Anti-Viral Medication Prevents Severe Eye Herpes
6. Common Food Dye Can Cause Severe Allergic Reactions
7. Oral Vaccine Protects Infants From Severe Rotavirus Diarrhea
8. Following complex motions
9. Study Suggests Vaccine Increases Survival In Ovarian And Breast Cancer Patients Following High-Dose Chemotherapy And Autologous Stem Cell Transplant
10. Spraying Water Containing Airborne Bacteria Found At Some Indoor Swimming PoolsCan Cause "Lifeguard Lung" Following Long-Term Exposure
11. High Temperature Immediately Following A Stroke Leads To Worse Outcome; Quick Cooling Shown To Have Benefit

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: