HOME >> BIOLOGY >> NEWS
Severe kidney disease in blacks linked to genes on two chromosomes

WINSTON-SALEM, N.C. As yet unidentified genes on chromosomes 18 and 3 are linked to severe kidney disease in younger blacks with diabetes, Barry I. Freedman, M.D., reported today at the American Society of Nephrology meeting in San Diego. Freedman, professor and head of the Section on Nephrology at Wake Forest University Baptist Medical Center, said blacks with these genes develop end-stage kidney disease at a much younger age. People with end-stage kidney disease require either regular dialysis or a kidney transplant to survive.

"This is the only report of this type in African-Americans," said Friedman, adding that the genes causing diabetic kidney disease may be the same as those found in some other ethic groups.

Freedman and a team that included eight other Wake Forest investigators studied 171 black families in which at least two siblings had developed kidney disease from type 2 diabetes; 312 individuals already had end-stage kidney disease. On average, diabetes began at age 39.

Using genome scans, the team's first set of analyses identified only weak evidence for the presence of kidney failure genes. But Freedman said that Carl D. Langefeld,. Ph.D., assistant professor of public health sciences (biostatistics) and Stephen S. Rich, Ph.D., professor of public health sciences and neurology, came up with a new way of analyzing the genetic data. "Using their novel analytic techniques allowed us to detect these regions containing kidney failure genes," he said.

The technique involved ranking 216 families by age when diabetes began and looking for linkages. Chromosome 18 emerged in the genomic study in people whose diabetes began at a younger age, while there was virtually no relationship to chromosome 18 in the older people. This indicated, they reported, that susceptibility in the younger group likely was related to the unidentified gene. Finding the region on a chromosome that is linked to a genetic defect is a major st
'"/>

Contact: Robert Conn
rconn@wfubmc.edu
336-716-4587
Wake Forest University Baptist Medical Center
14-Nov-2003


Page: 1 2

Related biology news :

1. Severe depression associated with greater number of nerve cells in thalamus region of brain
2. Severe Pain Following Shingles Safely Relieved In Clinical Trial Of Anti-Convulsant Drug Gabapentin
3. Scientists Find Gene For Severe Form Of Epilepsy
4. Severe Falciparum Malaria Increases In Honduras
5. Common Anti-Viral Medication Prevents Severe Eye Herpes
6. Common Food Dye Can Cause Severe Allergic Reactions
7. Oral Vaccine Protects Infants From Severe Rotavirus Diarrhea
8. Iron can have negative side effects on people with kidney disease
9. Newly grown kidneys can sustain life in rats
10. Fox Chase Cancer Center research shows kidney cancer can be diagnosed in urine
11. UT Southwestern researchers discover link that could aid in treatment of kidney cyst diseases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/4/2019)... ... 02, 2019 , ... Stay on top of current hot topics through free ... to all webinars is free, so be sure to register today to save your ... http://www.xtalks.com to see our upcoming webinars: , CLINICAL OPERATIONS , August 27 – ...
(Date:8/1/2019)... ... July 31, 2019 , ... Molecular ... launch of the next generation of its FLIPR® Penta High-Throughput Cellular Screening System. ... FLIPR® platform for monitoring of G-protein-coupled receptors (GPCRs) and ion channels, offering a ...
(Date:7/24/2019)... ... July 24, 2019 , ... NDA Partners Chairman Carl ... with more than 20 years of experience working in scientific research and FDA-regulated ... as an Expert Consultant. , Dr. Hartzfeld has experience in all aspects of ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... STATE COLLEGE, Pa. (PRWEB) , ... August 13, ... ... leader in nuclear receptor and in vitro toxicology testing solutions, announced the appointment ... of healthcare industry experience to the Board. , Mark McLoughlin will lend his ...
(Date:8/6/2019)... ... 06, 2019 , ... The San Diego Biotechnology Network (SDBN) ... SDBN BUZZ podcast focused on connecting the region’s biotech community and discussing topics ... the region and attract external employers, investors, scientists, and others who wish to ...
(Date:8/4/2019)... (PRWEB) , ... August 02, 2019 , ... Cirtec Medical ... invasive devices, today announced that it has begun construction on a 30,000 sq. ft. ... 15 miles from San Jose. , The facility, which is expected to be ...
(Date:7/19/2019)... ... July 18, 2019 , ... Global precision motion and ... current piezo motion facilities in Lederhose, Germany, increasing their current footprint by half ... assembly production in addition to general office space, a significant increase to its ...
Breaking Biology Technology:
Cached News: