HOME >> BIOLOGY >> NEWS
Sex Differences In Heart Disease May Be Due To Enzyme That Breaks Down Fat

SANTA FE, N.M., March 20 -- Sex-related differences in an enzyme that breaks down blood fats -- particularly "bad cholesterol" known as LDL -- may explain why men develop heart disease earlier than women, say scientists today at the American Heart Association's epidemiology and prevention conference.

"There are gender differences in the risk of coronary artery disease, the cause of heart attack. Pre-menopausal women have lower cholesterol levels and higher HDL levels (the good cholesterol) and lower heart disease rates than men," says the study's lead author, John E. Hokanson, Ph.D.

"We have observed in the past that there are higher levels of the enzyme hepatic lipase in men than in women. We asked the question, does hepatic lipase account for these lipid differences in men and women, and, if so, to what extent?" adds Hokanson, research scientist in the department of medicine at the University of Washington, Seattle.

Hokanson's research -- the first to focus on hepatic lipase and gender in heart disease -- could point to a new mechanism for increased risk for heart disease that characterizes men, when compared to women, before age 55. The research could suggest new ways to intervene to reduce that risk, he says.

In the study, scientists tested 25 men, 21 to 59 years old, and 39 pre-menopausal women, 21 to 51 years old. Both groups had normal cholesterol levels. Hepatic lipase activity was 53.4 percent higher in men than in women.

"The differences in the type of cholesterol we see in men and women appear to be related to hepatic lipase, and differences in this enzyme's activity may account for much of the difference in heart disease risk between men and pre-menopausal women," Hokanson says.

Researchers have in recent years been studying what they call the atherogenic phenotype, also called LDL subclass pattern B, which is characterized by predominantly small, dense LDL, low levels
'"/>

Contact: Carole Bullock
caroleb@amhrt.org
214-706-1279
American Heart Association
20-Mar-1998


Page: 1 2 3 4

Related biology news :

1. Sex Differences in Cardiovascular Disease
2. Differences between boys and girls show less than three weeks into pregnancy
3. Differences in response to amphetamines found between males and females pre-puberty
4. Autoimmune Diseases Study Shows Differences Between Men And Women
5. Evaluation Of The Two Types Of Cardiac Pacemakers Indicates Only Modest Differences In Value
6. Malnutrition Impacts Longevity Of Females More Than Males And Shows Gender Differences In Fruit Flies
7. Heart gene yields insights into evolution, disease risk
8. Heartless worms hold clues to cardiac arrhythmias, sudden death
9. Media invited to attend International Society For Heart & Lung Transplantation meeting April 21-24
10. Heart and lung transplantation clinical trial results to be announced at ISHLT meeting
11. Heart may heal with help from oxygen-sensitive genes, new study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... IRVINE, Calif. , May 24, 2016 Ampronix facilitates superior patient care ... LMD3251MT  3D medical LCD display is the latest premium product recently added to ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
(Date:4/19/2016)... DUBAI , UAE, April 20, 2016 ... can be implemented as a compact web-based "all-in-one" system ... in the biometric fingerprint reader or the door interface ... requirements of modern access control systems. The minimal dimensions ... the ID readers into the building installations offer considerable ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... June 23, 2016   EpiBiome , a precision ... million in debt financing from Silicon Valley Bank (SVB). ... and to advance its drug development efforts, as well ... "SVB has been an incredible strategic partner ... a traditional bank would provide," said Dr. Aeron ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... Francisco, CA (PRWEB) , ... June 23, 2016 ... ... (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase its ... Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical ...
Breaking Biology Technology:
Cached News: