HOME >> BIOLOGY >> NEWS
Sex Differences In Heart Disease May Be Due To Enzyme That Breaks Down Fat

SANTA FE, N.M., March 20 -- Sex-related differences in an enzyme that breaks down blood fats -- particularly "bad cholesterol" known as LDL -- may explain why men develop heart disease earlier than women, say scientists today at the American Heart Association's epidemiology and prevention conference.

"There are gender differences in the risk of coronary artery disease, the cause of heart attack. Pre-menopausal women have lower cholesterol levels and higher HDL levels (the good cholesterol) and lower heart disease rates than men," says the study's lead author, John E. Hokanson, Ph.D.

"We have observed in the past that there are higher levels of the enzyme hepatic lipase in men than in women. We asked the question, does hepatic lipase account for these lipid differences in men and women, and, if so, to what extent?" adds Hokanson, research scientist in the department of medicine at the University of Washington, Seattle.

Hokanson's research -- the first to focus on hepatic lipase and gender in heart disease -- could point to a new mechanism for increased risk for heart disease that characterizes men, when compared to women, before age 55. The research could suggest new ways to intervene to reduce that risk, he says.

In the study, scientists tested 25 men, 21 to 59 years old, and 39 pre-menopausal women, 21 to 51 years old. Both groups had normal cholesterol levels. Hepatic lipase activity was 53.4 percent higher in men than in women.

"The differences in the type of cholesterol we see in men and women appear to be related to hepatic lipase, and differences in this enzyme's activity may account for much of the difference in heart disease risk between men and pre-menopausal women," Hokanson says.

Researchers have in recent years been studying what they call the atherogenic phenotype, also called LDL subclass pattern B, which is characterized by predominantly small, dense LDL, low levels
'"/>

Contact: Carole Bullock
caroleb@amhrt.org
214-706-1279
American Heart Association
20-Mar-1998


Page: 1 2 3 4

Related biology news :

1. Sex Differences in Cardiovascular Disease
2. Differences between boys and girls show less than three weeks into pregnancy
3. Differences in response to amphetamines found between males and females pre-puberty
4. Autoimmune Diseases Study Shows Differences Between Men And Women
5. Evaluation Of The Two Types Of Cardiac Pacemakers Indicates Only Modest Differences In Value
6. Malnutrition Impacts Longevity Of Females More Than Males And Shows Gender Differences In Fruit Flies
7. Heart gene yields insights into evolution, disease risk
8. Heartless worms hold clues to cardiac arrhythmias, sudden death
9. Media invited to attend International Society For Heart & Lung Transplantation meeting April 21-24
10. Heart and lung transplantation clinical trial results to be announced at ISHLT meeting
11. Heart may heal with help from oxygen-sensitive genes, new study suggests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... -- The Allen Institute for Cell Science today announces the ... and dynamic digital window into the human cell. The ... of deep learning to create predictive models of cell ... growing suite of powerful tools. The Allen Cell Explorer ... available resources created and shared by the Allen Institute ...
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... first-ever genomics analysis platform specifically designed for life science researchers to analyze ... pioneering researcher Rosalind Franklin, who made a major contribution to the discovery ...
(Date:10/11/2017)... YORBA LINDA, CA (PRWEB) , ... October 11, ... ... adapted to upregulate any gene in its endogenous context, enabling overexpression experiments and ... activation (CRISPRa) system with small RNA guides is transformative for performing systematic gain-of-function ...
(Date:10/11/2017)... Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... set to take place on 7th and 8th June 2018 in San Francisco, CA. ... policy influencers as well as several distinguished CEOs, board directors and government officials from ...
(Date:10/11/2017)... 2017  VMS BioMarketing, a leading provider of patient support ... Nurse Educator (CNE) network, which will launch this week. The ... health care professionals to enhance the patient care experience by ... other health care professionals to help women who have been ... ...
Breaking Biology Technology:
Cached News: