HOME >> BIOLOGY >> NEWS
Sex Differences In Heart Disease May Be Due To Enzyme That Breaks Down Fat

SANTA FE, N.M., March 20 -- Sex-related differences in an enzyme that breaks down blood fats -- particularly "bad cholesterol" known as LDL -- may explain why men develop heart disease earlier than women, say scientists today at the American Heart Association's epidemiology and prevention conference.

"There are gender differences in the risk of coronary artery disease, the cause of heart attack. Pre-menopausal women have lower cholesterol levels and higher HDL levels (the good cholesterol) and lower heart disease rates than men," says the study's lead author, John E. Hokanson, Ph.D.

"We have observed in the past that there are higher levels of the enzyme hepatic lipase in men than in women. We asked the question, does hepatic lipase account for these lipid differences in men and women, and, if so, to what extent?" adds Hokanson, research scientist in the department of medicine at the University of Washington, Seattle.

Hokanson's research -- the first to focus on hepatic lipase and gender in heart disease -- could point to a new mechanism for increased risk for heart disease that characterizes men, when compared to women, before age 55. The research could suggest new ways to intervene to reduce that risk, he says.

In the study, scientists tested 25 men, 21 to 59 years old, and 39 pre-menopausal women, 21 to 51 years old. Both groups had normal cholesterol levels. Hepatic lipase activity was 53.4 percent higher in men than in women.

"The differences in the type of cholesterol we see in men and women appear to be related to hepatic lipase, and differences in this enzyme's activity may account for much of the difference in heart disease risk between men and pre-menopausal women," Hokanson says.

Researchers have in recent years been studying what they call the atherogenic phenotype, also called LDL subclass pattern B, which is characterized by predominantly small, dense LDL, low levels
'"/>

Contact: Carole Bullock
caroleb@amhrt.org
214-706-1279
American Heart Association
20-Mar-1998


Page: 1 2 3 4

Related biology news :

1. Sex Differences in Cardiovascular Disease
2. Differences between boys and girls show less than three weeks into pregnancy
3. Differences in response to amphetamines found between males and females pre-puberty
4. Autoimmune Diseases Study Shows Differences Between Men And Women
5. Evaluation Of The Two Types Of Cardiac Pacemakers Indicates Only Modest Differences In Value
6. Malnutrition Impacts Longevity Of Females More Than Males And Shows Gender Differences In Fruit Flies
7. Heart gene yields insights into evolution, disease risk
8. Heartless worms hold clues to cardiac arrhythmias, sudden death
9. Media invited to attend International Society For Heart & Lung Transplantation meeting April 21-24
10. Heart and lung transplantation clinical trial results to be announced at ISHLT meeting
11. Heart may heal with help from oxygen-sensitive genes, new study suggests

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sex Differences Heart Disease May Due Enzyme That Breaks Down Fat

(Date:7/2/2015)... , July 2, 2015 Fingerprint Cards ... FPC1035, FPC1145 and FPC1155 from the distributor World Peace Industrial ... FPC,s distributors in Asia . Deliveries are ... sensors will be used by smartphone manufacturers in ... included in the communicated revenue guidance of approximately 2,200 MSEK ...
(Date:6/29/2015)... , June 24, 2015 ... of the "Latin America Biomedical Sensors Market - ... offering. The Latin America Biomedical Sensors market ... CAGR of 2.04% over the period 2014-2020 ... adaptable to the genetic formulation of each individual. These ...
(Date:6/25/2015)... LAKE CITY , June 25, 2015  Imagine ... first steps toward a healthier, happier life. That,s exactly ... is designed to do. The cutting-edge, portable health program ... offers real-life solutions to help improve your lifestyle and ... Association awards dinner and gala Wednesday night, USANA,s THA ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2Latin America Biomedical Sensors Market Report 2015-2020 2@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2
(Date:7/28/2015)... ... July 28, 2015 , ... In terms of value, aluminium ... production volume reached close to 1.84 million tonnes in the same year. As ... of the region’s total aluminium hydroxide production; the country’s aluminium hydroxide production posted ...
(Date:7/28/2015)... , July 21, 2015 Research and ... of the "Biomedical Refrigerators and Freezers Market ... and Forecast 2014 - 2022" report to ... refrigerators and freezers market has been segmented based ... blood banks, and others. The others segment includes ...
(Date:7/28/2015)... July 28, 2015 Deerfield Management Company, L.P. ... Fund, L.P., which will invest in groundbreaking advancements in ... diseases, cancer, and orphan diseases. The venture capital fund ... therapeutics are developed and improve the way healthcare is ... the largest healthcare-focused venture funds in the sector, will ...
(Date:7/28/2015)... , July 28, 2015  Kerastem Technologies announce that ... the U.S. FDA Center For Biologics Evaluation and Research ... conduct a clinical trial investigating the safety and feasibility ... and early male pattern baldness (androgenic alopecia). ... follows initial clinical work in Europe ...
Breaking Biology Technology:EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 2EU27 Aluminium Hydroxide Market Analysed and Forecast by BAC Reports in New Research Study Available at MarketPublishers.com 3Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 2Biomedical Refrigerators and Freezers Market Report - Global Industry Analysis 2015 3Deerfield Launches $550 Million Healthcare Venture-Capital Fund 2Deerfield Launches $550 Million Healthcare Venture-Capital Fund 3Kerastem Receives Conditional Approval from FDA for Alopecia Trial 2
Cached News: