HOME >> BIOLOGY >> NEWS
Sex-specific differences in gene expression related to drug metabolism and hypertension

Many obvious physical and hormonal differences exist between men and women, and now researchers have discovered that there are major molecular differences as well. A new research study published in the June issue of Developmental Cell reveals that there are striking sex-specific patterns of gene expression that will likely provide critical insight into documented physiological differences, including sex-specific risk for disease.

Although there have been reports of differences in gene expression between males and females, there has not been a comprehensive study examining multiple tissue types. Dr. Michael Snyder from the Department of Molecular Biophysics and Biochemistry at Yale University and colleagues used a sophisticated genetic screening technique to look for molecular differences between mammalian sexes in multiple tissues. The researchers surveyed nearly 14,000 genes in the kidney, liver, and reproductive organs as well as in a brain region called the hypothalamus. "We looked for genes that were expressed in both sexes but significantly higher in one sex relative to the other and genes with expression detected only in one sex," explains Dr. Snyder. "We want to build a comprehensive map of the genetic and molecular differences between males and females. This map can be navigated to find insight into diseases known to have sex-specific propensities (e.g. anemia, hypertension, and renal dysfunction)."

Significant differences in gene expression were observed in the mouse liver, kidney, and reproductive tissues. Many of the differentially expressed genes were involved in drug and steroid metabolism and regulation of fluid balance. The results have interesting implications for explaining how males and females respond differently to drug treatments and sex-specific propensities for high blood pressure. Interestingly, the adult hypothalamus had very few sex-specific genes, despite its role as the control center for behavior. This
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
7-Jun-2004


Page: 1 2

Related biology news :

1. Sex-specific genes for depression
2. Genetic differences might help distinguish thyroid cancers
3. Study explains spatial orientation differences between sexes
4. Carnegie Mellon U. imaging study reveals sex-based differences that persist as mice enter adulthood
5. Young chimpanzees show sex differences in learning
6. Gene differences may alter susceptibility to multiple sclerosis
7. Estrogen promotes gender differences in brains response to stress
8. UB researchers show first evidence of pharmacogenomic differences in patients responses to MS drug
9. Genetic differences in termite castes may lead to better control
10. Genetic basis for gender differences in the liver
11. Genetic differences revealed by SNPS play a role in risk, prevention and outcome for cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/19/2019)... ... ... Project Lifeline – a community partnership and research program initiated ... use disorder (SUD) – will take center stage at the upcoming NACDS ... in preventing and treating opioid abuse in Blair County, Pennsylvania, will receive the NACDS ...
(Date:11/14/2019)... ... November 13, 2019 , ... NDA Partners Chairman Carl ... affairs and program management executive with more than 33 years of regulatory and ... firm as an Expert Consultant. , Robert Peterson has extensive experience in ...
(Date:11/12/2019)... ... November 12, 2019 , ... G5, the leader in real ... up to 25% and reduces cost-per-click by as much as 15%. An integral ... (MTA) to predict best advertising outcomes and automatically allocate daily ad investments across ...
Breaking Biology News(10 mins):
(Date:11/9/2019)... ... November 08, 2019 , ... ... use in pathology research, today announced the results of analyses examining the ... in the phase 3 selonsertib studies (STELLAR). Strong correlations were demonstrated between ...
(Date:11/5/2019)... ... November 04, 2019 , ... ... delivery technologies, development, and manufacturing solutions for drugs, biologics, gene therapies, and ... development technology, GPEx® Boost. The technology enhances Catalent’s proven GPEx expression platform ...
(Date:11/2/2019)... ... 2019 , ... A clinical trial usually involves many different ... principal investigators, supply chain managers, manufacturers, IRT, CRAs and so on. Lack of ... data, potentially leading to patient risk. , By having a single source of ...
(Date:10/30/2019)... S.D. (PRWEB) , ... October 30, 2019 , ... While ... of researchers and students at South Dakota School of Mines & Technology ... cells while leaving healthy cells alive. , If successful, the technique would prove ...
Breaking Biology Technology:
Cached News: