HOME >> BIOLOGY >> NEWS
Shedding Light On Circadian Rhythms

November 25, 1998-Several teams of scientists have found what may be the missing molecular link between sunlight and the circadian clocks in both mammals and fruit flies.

Circadian rhythms, the patterns of activity that occur on a 24-hour cycle, are important biological regulators in virtually every living creature. In mammals, the internal circadian clock resides in the brain, and sunlight is the cue that rewinds this clock daily. Researchers have now found a biochemical pathway that senses blue light, and thereby connects the sun to molecular components of the circadian clock, says Joseph Takahashi, an HHMI investigator at Northwestern University.

In an article published in the November 20, 1998, issue of Science, Takahashi and Aziz Sancar of the University of North Carolina School of Medicine in Chapel Hill report that the protein cryptochrome 2 serves as a transducer by which light drives the molecular machinery that generates circadian rhythm. Cryptochromes are light-reactive pigments found in the eye and in plants.

Cryptochrome proteins 1 and 2 (CRY1 and CRY2), which were first discovered in plants, trigger plant growth by responding to light in the blue to ultraviolet part of the spectrum. Another article in the same issue of Science explains how CRY1 and CRY 2 help regulate circadian rhythm in plants.

In the May 26, 1998, issue of Proceedings of the National Academy of Sciences, Yasuhide Miyamoto and Sancar showed that cells in the mouse and human retina express genes similar to those that code for plant cryptochromes. Takahashi, Sancar and their colleagues sought to find whether these genes were part of the eye's circadian light-sensing apparatus. There was ample circumstantial evidence: They knew that the same retinal cells that contain CRY1 and CRY2 are connected directly to the suprachiasmatic nucleus (SCN), a group of neurons deep in the mouse brain. The SCN has long been thought to be a crucial circadian pacemaker in mammals. They
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
25-Nov-1998


Page: 1 2 3

Related biology news :

1. Shedding new light on biology
2. Shedding Light on Disease: A Briefing for Journalists
3. Shedding light on luminescence: Scientists visualize structure of the photoprotein aequorin
4. Shedding light on the origin of primate color vision
5. Light turns on anticancer agents
6. Light Biology, a biotech company based on UT Southwestern technology, bought by NimbleGen Systems
7. Light at the end of the tunnel: Photonics are tipped to make global communications network a reality
8. Light shed on vision and hearing disorders
9. Light to moderate drinking during pregnancy can affect adolescent growth
10. Brookhaven Spotlights: News from the National Synchrotron Light Source
11. Light receptor may be key in how animals use Earths magnetic field

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/19/2019)... ... July 18, 2019 , ... VetStem Biopharma has long ... As a result of a two-year research collaboration with Calidi Biotherapeutics, VetStem ... platform in veterinary medicine. VetStem should be able to fast-track this cancer therapy ...
(Date:7/17/2019)... (PRWEB) , ... July 15, 2019 , ... ... computational science expertise exclusively for Life Sciences and Healthcare companies, announces the availability ... critical advisory services and strategic direction to start-up and emerging bio-pharma companies interested ...
(Date:7/10/2019)... ... July 10, 2019 , ... Inference Solutions , a ... today announced its role in Pizza Hut Australia’s digital transformation initiative ... A key part of this initiative is implementation of an automated call-steering application ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... , ... June 11, 2019 , ... ... Personalized Stem Cells Inc. (PSC) , has announced that their GMP facility ... Food and Drug Branch for manufacturing. This is an important milestone for ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... USPTO providing proprietary interest to our methodology, processes, and diagnostic techniques. The ... TREATMENT… extends Somnology’s IP rights including our proprietary sleep scoring methodology. The ...
(Date:5/22/2019)... , ... May 22, 2019 , ... Artemis ... a $8 million Series A funding round co-led by Astanor Ventures and ... State Development Fund and iSelect Fund . The company has raised $11.75m ...
(Date:5/14/2019)... ... May 13, 2019 , ... Leak ... instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is excited ... website aims to improve LDA’s ability to communicate directly with the marketplace; serving ...
Breaking Biology Technology:
Cached News: