HOME >> BIOLOGY >> NEWS
Shortened chromosomes linked to early stages of cancer development

Scientists at the Johns Hopkins Kimmel Cancer Center say they have evidence that abnormally short telomeres - the end-caps on chromosomes that normally preserve genetic integrity -appear to play a role in the early development of many types of cancer.

"Cancer researchers have debated whether shortened telomeres were a cause or effect of tumors," says Alan K. Meeker, Ph.D., lead author of the study and a postdoctoral fellow in urology and pathology at Hopkins. "What our study suggests is that telomere dysfunction may be a key component in the development of many epithelial cancers, those that arise from tissues lining our organs."

Studying tissue taken from small precancerous lesions in the bladder, esophagus, large intestine, mouth and cervix, the research team found abnormal telomere lengths in 97 percent of the cases examined. In particular, abnormally short telomeres were found in 88 percent of cases.

"We were surprised how often you see shortened telomeres this early in the development of these cancers," says Meeker. "It's a strong indicator that abnormal telomeres are likely playing a causal role in cancer development."

Telomeres cap the chromosome ends, protecting the interior, gene-containing parts of the chromosome from being accidentally lost. As normal cells divide and age, some of the telomere DNA is lost, and the telomeres get progressively shorter. Normal cells monitor the lengths of their telomeres and initiate cell suicide or halt cell division when telomeres get too short. Other researchers have shown in mice that cancer, which is characterized principally by unrestricted cell growth and lack of cell death, can occur if this monitoring system breaks down, leading to the development of chromosomal abnormalities.

"It appears that the telomere shortening frequently observed in large advanced tumors has already occurred before it can be detected by standard diagnostic tools, when cellular changes characteristi
'"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-955-1287
Johns Hopkins Medical Institutions
26-May-2004


Page: 1 2 3

Related biology news :

1. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
2. Abnormal chromosomes forecast leukemia relapse
3. Researchers substitute whole chromosomes to speed the search for genes in common diseases
4. UVa researchers describe method of protecting chromosomes during cell division
5. New way to lock DNA-slicing enzyme onto chromosomes could lead to novel anti-cancer drugs
6. Severe kidney disease in blacks linked to genes on two chromosomes
7. Rumors of male chromosomes demise greatly exaggerated, study finds
8. The nucleus: Not just a bag of chromosomes
9. Chromatin, not proteins, support chromosomes during cell division
10. Revealed: How a master protein remodels chromosomes to orchestrate gene expression
11. Regulating human X chromosomes doesnt use same gene as in mouse

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Shortened chromosomes linked early stages cancer development

(Date:10/29/2014)... Philadelphia, PA, October 29, 2014 – Ghrelin is a ... and food intake. Alcohol is commonly viewed as a ... is also a highly caloric food. , This ... to the hypothesis that ghrelin has the potential to ... colleagues tested this in humans and found that, as ...
(Date:10/28/2014)... news release is available in German . ... close relatives, the chimpanzees, acquire sufficient food when times ... National Park in Côte d,Ivoire researchers of the Max ... a clear example of how great apes can acquire ... show that chimpanzees make their sleeping nests more en ...
(Date:10/28/2014)... Individual differences in moving activity in a novel ... to angling, according to an experimental study completed ... Finnish Game and Fisheries Research Institute. The study ... groups and authentic angling trials to analyse if ... trout reared in traditional and enriched hatchery rearing ...
Breaking Biology News(10 mins):Ghrelin stimulates an appetite for drinking alcohol 2The early chimp gets the fig 2The early chimp gets the fig 3Fish 'personality' linked to vulnerability to angling 2
(Date:10/30/2014)... 2014 Investor-Edge has initiated coverage ... ONVO), Medivation Inc. (NASDAQ: MDVN ), Pharmacyclics ... (NYSE MKT: SYN), and Ironwood Pharmaceuticals Inc. (NASDAQ: IRWD). ... at: http://investor-edge.com/register . On Wednesday, October ... 0.33%, the Dow Jones Industrial Average declined 0.18%, to ...
(Date:10/30/2014)... 2014 SoundConnect , an ... Office 365 end users the key to turning ... system by adding voice enablement and hybrid audio ... Online, a communication tool that includes presence, instant ... voice, O365 becomes a comprehensive unified communications solution. ...
(Date:10/30/2014)... 30, 2014 Avure Technologies celebrates a year ... newest member of its fleet of high volume High Pressure ... anniversary as we return to PackExpo this year, which is ... Las Vegas,” said Jeff Williams, CEO at Avure. “Sales of ... pleased to be meeting the challenges of market demand for ...
(Date:10/30/2014)... solution to one of the key challenges in the ... of Sussex physicists. , In a paper published today ... Garraway and colleagues show how to make a new ... Quantum technology devices, such as high-precision sensors and specialised ... of atoms. But the methods for trapping these tiny ...
Breaking Biology Technology:Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 2SoundConnect Launches Voice Enablement and Hybrid Audio Conferencing for Office 365 3In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 2In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 3
Cached News: