HOME >> BIOLOGY >> NEWS
Sick Kids researchers identify cancer stem cell for brain tumours

A research team at The Hospital for Sick Children (HSC) and the University of Toronto (U of T), led by Dr. Peter Dirks, has identified for the first time a cancer stem cell in both malignant and benign brain tumours. This discovery may change how brain tumours are studied and how this deadly condition is treated in the future. This research is reported in the September 15, 2003 issue of the scientific journal Cancer Research.

"The discovery of a cancer stem cell for brain tumours means that only a small number of cells in a brain tumour have the ability to drive tumour growth. Many current cancer therapies may fail because they do not kill the cancer-sustaining stem cells. We now have to work on designing therapies that will attack these stem cells," said Dr. Peter Dirks, an HSC neurosurgeon and scientist-track investigator in the Developmental Biology Research Program, and an assistant professor of Neurosurgery at U of T.

Brain tumours are the leading cause of cancer mortality in children and remain difficult to cure despite advances in surgery and drug treatments. In adults, most brain tumours are also amongst the most sinister of cancers with formidable resistance to most therapies.

"We found that cancer stem cells from different tumour types, from aggressive malignant tumours to more slow-growing benign ones, share similar properties to each other as well as to normal brain stem cells. This suggests that mutations that lead to cancer formation may have originated in the brain's own small numbers of stem cells," said Dr. Sheila Singh, the paper's lead author, an HSC neurosurgery resident and U of T graduate student who is enrolled in HSC's Clinician-Scientist Training Program.

The biology of the brain tumour stem cell may also shed light on metastases (tumour spread). The non-stem cells in the tumour may break off and spread, but may not be able to grow at distant sites. "It is possible that only the tumour stem cells will be ab
'"/>

Contact: Laura Greer
laura.greer@sickkids.ca
416-813-5046
University of Toronto
15-Sep-2003


Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2019)... Calif. (PRWEB) , ... March 22, 2019 , ... ... Preparation Kit for Next Generation Sequencing (NGS) sample preparation. RhinoSeq employs a proprietary ... NGS market. The five-tube kit is comprised of preformatted master mixes for a ...
(Date:3/18/2019)... , ... March 18, 2019 , ... Periodontal disease, where ... loss, affects nearly 50% of the US population. Making this disease particularly challenging ... biofilm state, where the cells are enmeshed in a sticky extracellular material that makes ...
(Date:3/18/2019)... ... March 18, 2019 , ... ... leader in microbial solutions announce today they have entered into an agreement for ... breakthrough product for biologic nitrogen fixation for corn. This agreement ensures an easy-to-use ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... ALISO VIEJO, Calif. (PRWEB) , ... March 19, ... ... subsidiary of Konica Minolta, Inc. (Konica Minolta) today announced the formation of their ... dedicated to the advancement of precision medicine that takes into account individual variability ...
(Date:3/15/2019)... PAULO and ATLANTA (PRWEB) , ... ... ... completed the acquisition of 100% equity in American Process Inc. and affiliate ... include the Alpena Biorefinery in Alpena Michigan, the Thomaston Biorefinery and R&D ...
(Date:3/14/2019)... ... 2019 , ... Murrieta Genomics , the genomic sequencing business incubator, has ... business experience to bear as genomic sequencing startups build their business models. , “We ... that our Advisory Board brings to the table. Many of these experts would be ...
(Date:3/11/2019)... (PRWEB) , ... March 11, 2019 , ... In this ... considered to improve your clinical trial efficiency and experience. Participants will learn how to ... clinical IRT expertise to ensure that the simple or complex randomization scheme is properly ...
Breaking Biology Technology:
Cached News: