HOME >> BIOLOGY >> NEWS
Sick Kids researchers pinpoint link between diabetes and nervous system autoimmunity

TORONTO - Researchers at The Hospital for Sick Children (HSC) and the University of Toronto (U of T) have extended their earlier discovery of an unsuspected link between Type 1 diabetes and nervous system autoimmunity, such as that found in multiple sclerosis (MS). This research has identified new therapeutic targets for diabetes prevention, and a strategy for diagnostic tests for early detection of diabetes risk. The research is described in the February issue of the scientific journal Nature Medicine, available online on January 21, 2003.

The research group of HSC's Dr. Michael Dosch traced the link between Type 1 diabetes and nervous system autoimmunity to nervous tissue surrounding insulin-producing beta cells in the pancreas. They unexpectedly found that it is these nervous system structures that are first destroyed in the earliest stages of diabetes, with autoimmunity subsequently veering off to attack insulin-producing cells. Modification of the early nervous tissue attack prevented subsequent diabetes in the major animal model for the disease.

"This study maps the puzzling link between Type 1 diabetes and nervous system autoimmunity," said Dr. Dosch, the study's principal investigator, an HSC senior scientist and a professor of Paediatrics and Immunology at U of T. "In focusing previous research efforts strictly on insulin-producing beta cells, we may have missed the start of the diabetes process in its early, perhaps earliest, stages. The new data may shed a different light on the process, providing new targets for preventive treatments and new, early markers for the detection of disease risk, a prerequisite for intervention treatments."

Dr. Dosch's research group used a vaccine-type approach to alter autoimmunity against the pancreatic nervous system cells in mice, and they observed that subsequent diabetes development was reduced by a large margin. This implied a critical role of early neuronal autoimmunity in the process that eve
'"/>

Contact: Laura Greer
laura.greer@sickkids.ca
416-813-5046
University of Toronto
20-Jan-2003


Page: 1 2

Related biology news :

1. Belgian researchers explore revolutionary approach to angiogenesis
2. Award winning researchers reveal potential new role for Glivec
3. $7.5 Million grant to Yale researchers for role of viruses in cancer
4. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers
5. Joslin researchers clarify mechanisms for beta-cell formation
6. Virginia Tech researchers to release findings on Smith River Project
7. Molecular motor myosin VI moves hand over hand, researchers say
8. ASU researchers demonstrate new technique that improves the power of atomic force micrscopy
9. Emory researchers map structure of anti-cancer molecule
10. Leukemia stem cells identified by Stanford researchers
11. EURYI Award given for the first time to 25 young European researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... 2017  On April 6-7, 2017, Sequencing.com will host ... hackathon at Microsoft,s headquarters in Redmond, ... on developing health and wellness apps that provide a ... Genome is the first hackathon for personal genomics ... companies in the genomics, tech and health industries are ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities ... (physiological and behavioral), by technology (fingerprint, AFIS, iris recognition, ... recognition, and others), by end use industry (government and ... immigration, financial and banking, and others), and by region ... , Asia Pacific , and ...
(Date:3/28/2017)... -- The report "Video Surveillance Market by ... Devices), Software (Video Analytics, VMS), and Service (VSaaS, Installation ... 2022", published by MarketsandMarkets, the market was valued at ... reach USD 75.64 Billion by 2022, at a CAGR ... considered for the study is 2016 and the forecast ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... announced today that they have entered into a multiyear collaboration to identify and ... researchers with additional tools for gene editing across all applications. , Under the ...
(Date:10/12/2017)... ... October 12, 2017 , ... BioMedGPS announces expanded coverage ... its newest module, US Hemostats & Sealants. , SmartTRAK’s US Market for Hemostats ... sealants, synthetic sealants and biologic sealants used in surgical applications. BioMedGPS estimates the ...
(Date:10/12/2017)... (PRWEB) , ... October 12, ... ... ) has launched Rosalind™, the first-ever genomics analysis platform specifically designed for ... complexity. Named in honor of pioneering researcher Rosalind Franklin, who made a ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 system ... experiments and avoiding the use of exogenous expression plasmids. The simplicity of programming ... systematic gain-of-function studies. , This complement to loss-of-function studies, such as with ...
Breaking Biology Technology:
Cached News: