HOME >> BIOLOGY >> NEWS
'Silent' DNA speaks up for the first time

Until now, half of all genes in certain cells were thought to be inexpressible

By moderately raising the temperature of cells, biologists have broken through what was considered an impermeable barrier that kept half the genes in some cells "silent." The surprising results, in which these heated genes reached 500 times their normal rate of expression, could lead to better understanding of cellular processes involved in aging, fever and toxicity.

Biochemistry and molecular biology professor David Gross and graduate student Edward Sekinger conducted the research at Louisiana State University Health Science Center (LSUHSC) with support from the National Science Foundations (NSF) Division of Molecular and Cellular Biosciences. The findings appear in the current issue of the journal Cell.

More than half the genes in a typical human cell never get expressed due to a shield-like coating of proteins called "chromatin." In many genes, chromatin does not prevent the expression of DNAs genetic codes. But in genes coated with extremely dense "heterochromatin," the DNA stays quarantined from triggers that would otherwise cause transcription, the process by which genes dictate characteristics such as hair and eye color.

"Until now, genes sheathed in heterochromatin were assumed incapable of being expressed due to an absence of trigger proteins," Gross said. "This research shows that these proteins do naturally penetrate the heterochromatin, but once inside cannot function. Our evidence indicates that heating the cells activates these proteins, causing a heat-responsive gene to be expressed at a very high rate."

Using yeast as a model because it has many genes in common with humans, Gross and Sekinger raised the cells' temperature from its normal 86 degrees to 102 degrees. The cells woke up with a vengeance, expressing the silent, heat-responsive gene at 500 times the normal frequency.

Messenger RNA (mRNA) is a c
'"/>

Contact: Tom Garritano
tgarrita@nsf.gov
703-292-8070
National Science Foundation
15-May-2001


Page: 1 2

Related biology news :

1. NJIT chemist speaks Aug. 25 about compound derived from pine tree
2. Stanford biomedical ethicist speaks on role of race in scientific research
3. Harvard expert speaks on lead toxicity to chemists meeting in New Orleans
4. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
5. Newly identified master gene key in babys first breath
6. The book opens on the first tree genome
7. DuPont developing new protective suits for military, first responders
8. Joslin Diabetes Center adds first affiliate in California at Irvine Medical Center
9. Maine-based biophysics institute gets funding for first US-based 4Pi nanoscale microscope
10. Veterinarians discover first known case of canine distemper in a wild tiger
11. Study reveals first genetic step necessary for prostate cancer growth

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/25/2019)... ... September 25, 2019 , ... ... have placed over 20,000 dental implants for a variety of procedures, including single ... and pterygoid dental implants. Dental implants offer patients permanent tooth replacement ...
(Date:9/24/2019)... ... September 23, 2019 , ... Global molecular diagnostics company ... Holotype HLA and other Omixon products will be featured among 10 posters and ... Histocompatibility and Immunogenetics (ASHI) in Pittsburgh, PA. Omixon’s Lunch Symposium on Thursday ...
(Date:9/22/2019)... ... September 20, 2019 , ... A new ... client demands for precision medicine products. The report, Lab Instrumentation Markets for ... 2018, the pharma/bio sector is the largest source of demand for laboratory instrumentation. ...
Breaking Biology News(10 mins):
(Date:10/3/2019)... , ... October 01, 2019 , ... Cheyenne is a ... Mimi, Cheyenne’s owner, owns and operates Rebel’s Run , which offers riding ... favorite amongst students and trail riding guests. Mimi describes her as her “go ...
(Date:10/3/2019)... BOSTON (PRWEB) , ... October 03, 2019 , ... Yesterday, ... 2-3, Asymmetrex founder and director, James L. Sherley, M.D., Ph.D., discussed important ... To an attendee audience including both developers and suppliers of clinical trials, in ...
(Date:9/24/2019)... (PRWEB) , ... September 24, 2019 , ... ... stem cell company, has completed training and site qualification for clinical trial sites ... of recruitment and screening of potential clinical trial participants. , Clinical trial sites ...
(Date:9/17/2019)... ... September 17, 2019 , ... Tucker, a Labrador retriever, was just a puppy ... was limping and lame on his right hip and elbow. At one year of ... “the worst case the vet had seen.” He was prescribed pain medications, both oral ...
Breaking Biology Technology:
Cached News: