HOME >> BIOLOGY >> NEWS
Simian virus 40 not associated with non-Hodgkin lymphoma, study shows

Non-Hodgkin lymphoma (NHL) patients are no more likely than healthy people to have been exposed to or infected by simian virus 40 (SV40), a macaque polyomavirus that contaminated poliovirus vaccines in the mid-20th century, according to a new study in the September 15 issue of the Journal of the National Cancer Institute. SV40 has been suggested as a cause of human cancers, including NHL.

In the United States between 1955 and 1962, SV40 frequently contaminated poliovirus vaccines, which were grown in monkey kidney tissue. Several groups have reported detection of SV40 in the tumor tissue of 15% to 43% of NHL patients, and the virus causes leukemia and lymphoma in laboratory rodents. However, other research groups did not detect SV40 in NHL tumors, and recent evidence has suggested that it cannot infect human lymphocytes. Moreover, epidemiologic studies have failed to find an increase in the risk of NHL among people exposed to SV40-contaminated poliovirus vaccine.

To examine the possible association between exposure to SV40 and NHL, Eric A. Engels, M.D., M.P.H., of the National Cancer Institute, and colleagues conducted a population-based casecontrol study of 724 NHL patients and 622 control subjects. In the study, two independent laboratories tested for antibodies to SV40 in all of the subjects using two similar tests that utilize SV40 virus-like particles.

SV40 seropositivity--the presence of antibodies to SV40 virus-like particles--was detected in 7% to 10% of NHL case patients and 10% to 11% of control subjects. When the researchers accounted for cross-reactivity with the related human polyomaviruses BK and JC, they found SV40-specific antibody in less than 2% of both case patients and control subjects. The researchers thus found no association between SV40 exposure or infection and an increased risk of NHL.

"Based on the assumption that SV40 infection would have resulted in a measurable immune response to virion proteins,
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
14-Sep-2004


Page: 1 2

Related biology news :

1. Pacific Northwest team unveils largest virus proteome to date
2. No role for simian virus 40 in human pleural mesotheliomas
3. Cannabis may help combat cancer-causing herpes viruses
4. Scientists find nanowires capable of detecting individual viruses
5. $7.5 Million grant to Yale researchers for role of viruses in cancer
6. Common cold virus can cause polio in mice when injected into muscles
7. Defensive action by influenza viruses demonstrated by Hebrew university researcher
8. Study of flu patients reveals virus outsmarting key drug
9. Images reveal how rotavirus - leading cause of diarrhea - enters cells
10. Bright idea could doom cancer and viruses, say Purdue scientists
11. U-M scientists find common virus in human prostate tissue

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
(Date:4/5/2017)... -- The Allen Institute for Cell Science today announces the ... and dynamic digital window into the human cell. The ... of deep learning to create predictive models of cell ... growing suite of powerful tools. The Allen Cell Explorer ... available resources created and shared by the Allen Institute ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 system ... experiments and avoiding the use of exogenous expression plasmids. The simplicity of programming ... systematic gain-of-function studies. , This complement to loss-of-function studies, such as with ...
(Date:10/11/2017)... the Netherlands and LAGUNA HILLS, Calif. ... The Institute of Cancer Research, London ... use MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients ... trial known as MUK nine . The University of ... trial, which is partly funded by Myeloma UK, and ICR ...
(Date:10/10/2017)... CA (PRWEB) , ... October ... ... a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today ... of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM Life Sciences ... the life sciences and healthcare industries, announces a presentation by Subbu Viswanathan and ... presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a revolutionary approach ...
Breaking Biology Technology:
Cached News: