HOME >> BIOLOGY >> NEWS
Simian virus 40 not associated with non-Hodgkin lymphoma, study shows

Non-Hodgkin lymphoma (NHL) patients are no more likely than healthy people to have been exposed to or infected by simian virus 40 (SV40), a macaque polyomavirus that contaminated poliovirus vaccines in the mid-20th century, according to a new study in the September 15 issue of the Journal of the National Cancer Institute. SV40 has been suggested as a cause of human cancers, including NHL.

In the United States between 1955 and 1962, SV40 frequently contaminated poliovirus vaccines, which were grown in monkey kidney tissue. Several groups have reported detection of SV40 in the tumor tissue of 15% to 43% of NHL patients, and the virus causes leukemia and lymphoma in laboratory rodents. However, other research groups did not detect SV40 in NHL tumors, and recent evidence has suggested that it cannot infect human lymphocytes. Moreover, epidemiologic studies have failed to find an increase in the risk of NHL among people exposed to SV40-contaminated poliovirus vaccine.

To examine the possible association between exposure to SV40 and NHL, Eric A. Engels, M.D., M.P.H., of the National Cancer Institute, and colleagues conducted a population-based casecontrol study of 724 NHL patients and 622 control subjects. In the study, two independent laboratories tested for antibodies to SV40 in all of the subjects using two similar tests that utilize SV40 virus-like particles.

SV40 seropositivity--the presence of antibodies to SV40 virus-like particles--was detected in 7% to 10% of NHL case patients and 10% to 11% of control subjects. When the researchers accounted for cross-reactivity with the related human polyomaviruses BK and JC, they found SV40-specific antibody in less than 2% of both case patients and control subjects. The researchers thus found no association between SV40 exposure or infection and an increased risk of NHL.

"Based on the assumption that SV40 infection would have resulted in a measurable immune response to virion proteins,
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
14-Sep-2004


Page: 1 2

Related biology news :

1. Pacific Northwest team unveils largest virus proteome to date
2. No role for simian virus 40 in human pleural mesotheliomas
3. Cannabis may help combat cancer-causing herpes viruses
4. Scientists find nanowires capable of detecting individual viruses
5. $7.5 Million grant to Yale researchers for role of viruses in cancer
6. Common cold virus can cause polio in mice when injected into muscles
7. Defensive action by influenza viruses demonstrated by Hebrew university researcher
8. Study of flu patients reveals virus outsmarting key drug
9. Images reveal how rotavirus - leading cause of diarrhea - enters cells
10. Bright idea could doom cancer and viruses, say Purdue scientists
11. U-M scientists find common virus in human prostate tissue

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2018)... (PRWEB) , ... August 29, ... ... study validates first non-invasive technology to identify specific chromosomal abnormalities using morphological ... Ovation Fertility and Australia-based Life Whisperer suggests that ...
(Date:8/26/2018)... ... August 24, 2018 , ... ... laboratories. However, this technology introduces many well-described challenges around data processing, storage ... South London NHS Genomic Medicine Centre. The Viapath Genetics Laboratories have implemented ...
(Date:8/23/2018)... ... ... Mandy is an eight-year-old mini Australian shepherd and a tripod. When Mandy was four years ... surgeries to try to repair the leg and each time it was unsuccessful. Once ... along with her veterinarian, decided to amputate. With only one front leg, mobility in ...
Breaking Biology News(10 mins):
(Date:9/13/2018)... ... ... Asymmetrex’s director, James L. Sherley, M.D., Ph.D., asks audiences questions like, “How ... the means to measure the number of drug molecules in drug development research or ... holding up progress in stem cell medicine.” , “Can you imagine taking an approved ...
(Date:9/12/2018)... ... September 12, 2018 , ... NDA Partners Chairman Carl ... Senior Director of Regulatory Affairs and Quality Systems at WellDoc, Inc., has joined ... Affairs and Quality Systems at WellDoc, Inc., she conducted quality control and supplier ...
(Date:9/7/2018)... ... September 06, 2018 , ... ... disease, has been validated to be as effective as manual pathology. The study, ... in Frozen Muscle Biopsies,” was published in the Archives of Pathology & Laboratory ...
(Date:8/31/2018)... ... August 30, 2018 , ... Small, wireless and networked describes ... down and getting connected, too. Draper’s latest system is tiny in size, but is ... A driving factor in the new implant design is the growing awareness that disease ...
Breaking Biology Technology:
Cached News: