HOME >> BIOLOGY >> NEWS
Similar genetic origins possible for schizophrenia and bipolar disorder

A study by researchers at the Johns Hopkins Children's Center, University of Cambridge and the Stanley Medical Research Institute appears to offer the first hard evidence that schizophrenia and bipolar disorder, severe psychoses that affect 2 percent of the population, may have similar genetic roots.

The study's findings, reported in the Sept. 6 issue of The Lancet, trace the disorders to reduced expression of the genes, known as oligodendrocytes, responsible for myelin development in brain cells. Composed mostly of fats and proteins, myelin sheaths insulate nerve cells, enabling them to safely conduct electric signals between the brain and other parts of the body.

"Patients with schizophrenia and bipolar disorder differ in terms of their presentation and clinical course," says the study's co-author, Robert Yolken, M.D., a neurovirologist at the Children's Center.

"However, there is some overlap in terms of symptoms and there are medications that have been used for the treatment of both disorders. Our findings suggest that there are similar mechanisms involved in both disorders and that they may be more closely related than previously thought."

In the study, researchers compared expression of myelin-associated genes in the preserved brains of 15 people with schizophrenia, 15 with manic-depressive illness (bipolar disorder), and 15 from a control group of individuals with neither disorder.

"The expression profiles of most known oligodendrocyte-specific and myelin-associated genes were greatly reduced, and several transcription factors known to coordinate myelin gene expression showed corresponding changes," says Yolken. "These results provide strong evidence for oligodendrocyte and myelin dysfunction in patients with schizophrenia and bipolar disorder."

Yolken says the reason for this dysfunction is not currently known, but may be related, in some cases, to infections of the central nervous system or other env
'"/>

Contact: Jessica Collins
jcolli31@jhmi.edu
410-516-4570
Johns Hopkins Medical Institutions
9-Sep-2003


Page: 1 2

Related biology news :

1. Strikingly Similar protein may be in Alzheimers and Mad Cow Disease
2. Fossil Footprints Show Foot-Movement Similarity In Dinosaurs And Birds
3. Researchers Show Mechanism And Similarities Of Biological Clocks
4. Similarities Found In Human, Chimp Brains; Columbia, Mount Sinai, NIH Scientists Find Region That Controls Language Identical In Both Species
5. Proteins Interacting With RNA And DNA Are Surprisingly Similar
6. Researchers determine genetic cause of Timothy syndrome
7. Rare childhood genetic syndrome identified
8. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
9. Scientists decipher genetic code of biothreat pathogen
10. Chemical genetics identifies SARS inhibitors
11. 22nd amino acid synthesized and added to genetic code of e. coli bacteria

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , April 11, 2017 No two ... researchers at the New York University Tandon School ... Engineering have found that partial similarities between prints ... used in mobile phones and other electronic devices ... The vulnerability lies in the fact that ...
(Date:4/5/2017)... 5, 2017  The Allen Institute for Cell Science ... a one-of-a-kind portal and dynamic digital window into the ... the first application of deep learning to create predictive ... lines and a growing suite of powerful tools. The ... and future publicly available resources created and shared by ...
(Date:4/4/2017)... NEW YORK , April 4, 2017   ... solutions, today announced that the United States Patent and ... The patent broadly covers the linking of an iris ... the same transaction) and represents the company,s 45 th ... our latest patent is very timely given the multi-modal ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... Phoenix, Arizona (PRWEB) , ... ... ... is proud to introduce the Fluidnatek® Electrospinning and Electrospraying ... and electrospraying equipment scales from table-top equipment for the lab to fully ...
(Date:8/16/2017)... 16, 2017  This year,s edition of the Inc. 5000 features a ... workforce solutions, has made the list for the third year in a ... fastest-growing private companies based on a set of quantitative metrics. In addition, ... fastest-growing companies in the Bay State . ... Inc. 5000 ...
(Date:8/15/2017)... PA (PRWEB) , ... August 15, 2017 , ... ... one of the largest Asian exhibitions for analytical and scientific instruments. This year’s ... will be “New Approaches in Mass Spectrometry for Bioanalytical Applications.” This dynamic presentation ...
(Date:8/15/2017)... ... August 15, 2017 , ... ... Now mobile responsive, the new website makes it easy to navigate through the ... Users can now find detailed product information, educational industry content and visit the ...
Breaking Biology Technology:
Cached News: