HOME >> BIOLOGY >> NEWS
Similar genetic origins possible for schizophrenia and bipolar disorder

A study by researchers at the Johns Hopkins Children's Center, University of Cambridge and the Stanley Medical Research Institute appears to offer the first hard evidence that schizophrenia and bipolar disorder, severe psychoses that affect 2 percent of the population, may have similar genetic roots.

The study's findings, reported in the Sept. 6 issue of The Lancet, trace the disorders to reduced expression of the genes, known as oligodendrocytes, responsible for myelin development in brain cells. Composed mostly of fats and proteins, myelin sheaths insulate nerve cells, enabling them to safely conduct electric signals between the brain and other parts of the body.

"Patients with schizophrenia and bipolar disorder differ in terms of their presentation and clinical course," says the study's co-author, Robert Yolken, M.D., a neurovirologist at the Children's Center.

"However, there is some overlap in terms of symptoms and there are medications that have been used for the treatment of both disorders. Our findings suggest that there are similar mechanisms involved in both disorders and that they may be more closely related than previously thought."

In the study, researchers compared expression of myelin-associated genes in the preserved brains of 15 people with schizophrenia, 15 with manic-depressive illness (bipolar disorder), and 15 from a control group of individuals with neither disorder.

"The expression profiles of most known oligodendrocyte-specific and myelin-associated genes were greatly reduced, and several transcription factors known to coordinate myelin gene expression showed corresponding changes," says Yolken. "These results provide strong evidence for oligodendrocyte and myelin dysfunction in patients with schizophrenia and bipolar disorder."

Yolken says the reason for this dysfunction is not currently known, but may be related, in some cases, to infections of the central nervous system or other env
'"/>

Contact: Jessica Collins
jcolli31@jhmi.edu
410-516-4570
Johns Hopkins Medical Institutions
9-Sep-2003


Page: 1 2

Related biology news :

1. Strikingly Similar protein may be in Alzheimers and Mad Cow Disease
2. Fossil Footprints Show Foot-Movement Similarity In Dinosaurs And Birds
3. Researchers Show Mechanism And Similarities Of Biological Clocks
4. Similarities Found In Human, Chimp Brains; Columbia, Mount Sinai, NIH Scientists Find Region That Controls Language Identical In Both Species
5. Proteins Interacting With RNA And DNA Are Surprisingly Similar
6. Researchers determine genetic cause of Timothy syndrome
7. Rare childhood genetic syndrome identified
8. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
9. Scientists decipher genetic code of biothreat pathogen
10. Chemical genetics identifies SARS inhibitors
11. 22nd amino acid synthesized and added to genetic code of e. coli bacteria

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, ... security technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate ... ... NXT-ID, we look forward to their guidance and benefiting from ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... 2017 , ... Panitch Schwarze Belisario & Nadel ... (Biomedical Innovation Group) annual meeting in China. , This year’s meeting, held June ... therapy, a rapidly developing highly personalized anti-cancer technology that involves removing some of ...
(Date:7/16/2017)... ... July 16, 2017 , ... OHAUS ... announced the launch of its new line of Rocking and Waving Shakers today. ... shaker models (both analog and digital) for laboratory applications in a variety of ...
(Date:7/14/2017)... ... ... Sonic Manufacturing Technologies is proud to be an ... on its roof top. “We will be independent of the grid and completely ... company’s proud history of social responsibility and participation in the preservation of Silicon ...
(Date:7/14/2017)... ... July 14, 2017 , ... Diagenode and ... proteins to clean peptides for mass spectrometry (MS) analysis combining the PreOmics in-StageTip ... iST Kit is based on proprietary technology that contains optimized buffer systems permitting ...
Breaking Biology Technology:
Cached News: