Single enzyme may be linked to obesity

BOSTON The increased activity of a single enzyme in fat cells may be a common cause of obesity and obesity-linked diseases, including diabetes, according to an animal study conducted by researchers at Beth Israel Deaconess Medical Center and the University of Edinburgh and published in the Dec. 7 issue of Science. The findings could eventually pave the way for future drug development to curb visceral obesity the beer belly fat concentrated in the abdomen.

Hundreds of studies have led to the conclusion that any fat can be problematic, but its much, much more dangerous when its accumulated in the abdomen, notes lead author Jeffrey S. Flier, M.D., an endocrinologist at Beth Israel Deaconess Medical Center and the George C. Reisman Professor of Medicine at Harvard Medical School. Pound for pound, intra-abdominal fat is much more likely to cause diabetes, heart disease and other diseases that make up the metabolic syndrome.

To identify the molecular mechanism behind the accumulation of the excess abdominal fat, Flier and his colleagues looked at the role of the glucocorticoid hormone cortisol, the fight or flight hormone that helps people survive stressful situations. Observations of patients with the endocrine disorder Cushing's syndrome who have too much cortisol in their blood had shown that they develop increased intra-abdominal fat as well as other metabolic symptoms. This led Flier to hypothesize that obese patients who don't typically have increased blood cortisol levels may be producing increased amounts of cortisol in their fat cells.

To test this hypothesis, Flier and his colleagues studied the enzyme 11beta hydroxysteroid dehydrogenase type 1 (11 beta HSD-1), which has the unique ability to produce cortisol in cells that are not normally associated with cortisol production. This enzyme is known to be present in fat cells.

The researchers created a group of transgenic (Tg) mice that overproduce 11 beta HSD-1 in roughly t

Contact: Jerry Berger
Beth Israel Deaconess Medical Center

Page: 1 2 3

Related biology news :

1. Single isolated mouse skin cell can generate into variety of epidermal tissues
2. Single gene mutation muddying Parkinsons risk forecasts
3. Single gene controls leaf form
4. Single molecules observed
5. Single gene leap led to flea-borne transmission of plague bacterium
6. Single cell type seems to control internal clock and pupil of eye
7. Single virus tracing sets the stage for new infection-fighting drugs and gene-therapy strategies, Science authors say
8. Single amino acid mutation dramatically alters direction of a molecular motor
9. Single switch triggers two immune system genes
10. Single amino acid change in herpes virus prevents it from infecting neurons
11. Alzheimers Disease And Developmental Biology Linked Through Single Molecule

Post Your Comments:

(Date:8/23/2020)... ... August 21, 2020 , ... The August edition of ... now available on the company’s global website. Crystallography Times—an electronic newsletter published by ... news and crystallographic research. , The latest issue of Crystallography Times introduces ...
(Date:8/21/2020)... CARLSBAD, Calif. (PRWEB) , ... August 19, 2020 ... ... of both Salimetrics LLC and SalivaBio LLC, businesses dedicated to Salivary Bioscience for ... co-editor of the recently published book by Springer, " Salivary Bioscience: Foundations of ...
(Date:8/21/2020)... ... August 20, 2020 , ... NDA Partners Chairman Carl ... executive with expertise in clinical trial planning and feasibility, regulatory inspection readiness, and ... Throughout his career, Mr. Movahhed has helped design and manage oncology, neurology, cardiovascular, ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... , ... July 29, 2020 , ... ... solid-state radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, ... that can drive one or two switches in a push-pull configuration; yielding fast ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... today announced the release of its signature product called Beacon - a ... and other field medical professionals. , Beacon helps MSLs streamline communication ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , a ... and food industries, is pleased to announce that Charles Galea has joined its ... , Charles is an accomplished and results-driven sales executive with over 10 years ...
(Date:7/7/2020)... ... July 06, 2020 , ... R3 International is now ... up to 200 million stem cells. Depending on the patient's condition, treatment may be ... US will die having some form of Alzheimers dementia, and the incidence continues to ...
Breaking Biology Technology:
Cached News: