HOME >> BIOLOGY >> NEWS
Single isolated mouse skin cell can generate into variety of epidermal tissues

Researchers at the Howard Hughes Medical Institute at The Rockefeller University have isolated stem cells from the skin of a mouse, and showed, for the first time, that an individual stem cell can renew itself in the laboratory and then be used in grafts to produce skin, hair and oil glands.

The study, published in the September 3 issue of the journal Cell, not only demonstrates for the first time the multipotent power of these stem cells, but also holds promise for possible future application of these techniques for the treatment of human skin and hair conditions, says the study's lead investigator, Elaine Fuchs, Ph.D., professor and head of the Laboratory of Mammalian Cell Biology and Development at Rockefeller and an investigator at HHMI. Fuchs also is a member of the Robert and Harriet Heilbrunn Center for Stem Cell Research at Rockefeller.

"This is first work that indicates a single skin stem cell can generate both epidermis and hair, even after propagation in the lab," Fuchs says. "The potential of these stem cells is very exciting."

And in the future, she says, it may be possible to test if human skin cells can also be pushed to grow into other epithelial cells, such as eye cornea or tooth enamel, or even different types of tissues. "My interest has always been to understand biology with an eye toward eventual clinical applications," Fuchs says. "So far, this study has provided some of the answers that we will need to make this possible."

One possible application for the findings is to see if these methods can now be adapted to isolate human hair stem cells for developing future treatments for baldness, she says. In the present study, the Fuchs' team of researchers were able to isolate these stem cells from normal mice, graft them on to the backs of hairless mice, and generate luxuriant hair growth, as well as new glands to oil the hair and fresh skin.

In contrast to recent methods published earlier this year by Fuchs
'"/>

Contact: Lynn Love
lovel@rockefeller.edu
212-327-8977
Rockefeller University
3-Sep-2004


Page: 1 2 3 4

Related biology news :

1. Single gene mutation muddying Parkinsons risk forecasts
2. Single gene controls leaf form
3. Single molecules observed
4. Single gene leap led to flea-borne transmission of plague bacterium
5. Single cell type seems to control internal clock and pupil of eye
6. Single enzyme may be linked to obesity
7. Single virus tracing sets the stage for new infection-fighting drugs and gene-therapy strategies, Science authors say
8. Single amino acid mutation dramatically alters direction of a molecular motor
9. Single switch triggers two immune system genes
10. Single amino acid change in herpes virus prevents it from infecting neurons
11. Alzheimers Disease And Developmental Biology Linked Through Single Molecule

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/4/2020)... ... March 04, 2020 , ... The Massachusetts Medical Device Industry ... IGNITE program’s 2020 IGNITE Cohort. The MedTech IGNITE Program is a virtual accelerator ... next generation of medtech founders and entrepreneurs. IGNITE Cohort members get access to ...
(Date:3/3/2020)... ... March 03, 2020 , ... Board-certified oral and maxillofacial surgeon, ... over 16 years of training and experience, Dr. Noffze can successfully extract problem and ... as soon as possible is beneficial to the oral and overall health of most ...
(Date:3/2/2020)... ... 02, 2020 , ... Rigaku Corporation is pleased ... and Applied Spectroscopy ( Pittcon 2020 ), being held March 1 - 5, ... and exposition on laboratory science, attracting attendees from industry, academia and government from ...
Breaking Biology News(10 mins):
(Date:3/27/2020)... ... March 25, 2020 , ... ... veterinary histopathology laboratory located centrally in the midwest for high-quality, quick-turn, board-certified ... with a highly motivated, independent, professional team that is focused on incredible ...
(Date:3/12/2020)... , ... March 12, 2020 , ... ... atomic force microscopy (AFM) technology, increases the business investment in Europe by inaugurating ... , The Grand Opening Ceremony of the new Nanoscience Center Europe took place ...
(Date:3/4/2020)... WASHINGTON (PRWEB) , ... March 04, 2020 , ... This ... Exhibition in Orlando, FL. The company will showcase both expanded and emerging offerings that ... HIMSS 2020 is designed to be comprehensive, timely, and engaging. From ...
(Date:2/26/2020)... ... February 25, 2020 , ... Continuing its leading ... the results of its safety assessment on the biotechnologically produced 3-Fucolsyllactose (3-FL) HMO. ... milk. These complex carbohydrates are indigestible and therefore function as a prebiotic by ...
Breaking Biology Technology:
Cached News: