HOME >> BIOLOGY >> NEWS
Sixty-day antibiotic treatment not enough to prevent anthrax in some cases

The 60-day dose of antibiotics recommended by doctors to prevent anthrax may not be long enough in some cases, according to an analysis conducted by researchers at the Johns Hopkins Bloomberg School of Public Health. Mathematical analysis shows that prophylaxis antibiotics may be needed for as long as four months for people exposed to high levels of anthrax spores. The new model also provides a valuable tool for estimating exposure doses in future outbreaks that can then be used to determine the optimum window for antibiotic therapy. The analysis appears in the July 28, 2003, issue of the Proceedings of the National Academy of Sciences.

"Anthrax spores are expelled from the lungs at a specific rate. Our model calculates the time it takes the body to expel these spores. A single spore left behind can germinate to cause disease," explained Ron Brookmeyer, PhD, lead author of the study and professor of biostatistics at the School of Public Health. "The model we developed shows that larger exposures to anthrax spores take longer to expel and require longer antibiotic therapy. Sixty days of antibiotics provides adequate protection in outbreaks with low exposure to spores. However, four months of antibiotics are required for outbreaks in which persons are exposed to large numbers of spores."

Dr. Brookmeyer and his colleagues tested their model using data from the 2001 anthrax attack on the United States and the 1979 anthrax outbreak near a biological weapons plant in Sverdlovsk, Russia. In both cases, the model's predictions were consistent with the actual illness rates.

"During the 2001 U.S. anthrax attacks, many people failed to take the recommended 60-day course of antibiotics. Full compliance was about 60 percent or less in some cases. Our model showed that the reason they didn't get sick even without the antibiotics was because the anthrax spore exposure levels were very low. If the exposure levels were higher, there would have been more casu
'"/>

Contact: Tim Parsons
paffairs@jhsph.edu
410-955-6878
Johns Hopkins University Bloomberg School of Public Health
28-Jul-2003


Page: 1 2

Related biology news :

1. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
2. Smart antibiotics may result from UCLA research
3. K-State researcher working to improve alternatives to equine antibiotics
4. Bacterial protein recycling factor possible key to new class of antibiotics
5. Bacteria spill their guts to aid researchers in quest for new antibiotics
6. Molecule that blocks key bacterial enzyme may lead to new antibiotics
7. Does antibiotic use contribute to allergies?
8. Tigecycline - Candidate antibiotic produces 74 percent cure rate in cSSSI patients
9. Tigecycline - antibiotic evaluated in surveillance trial
10. Data show investigational antibiotic safe, effective in preventing travelers diarrhea
11. Chicken litter harbors agents that generate antibiotic multi-resistance, according to UGA study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2020)... ... 2020 , ... Cryo-Cell International’s announcement is concurrent with the ... Hal Boxmeyer and colleagues, which determined sample viability of 23.5 years and suggested ... Cryo-Cell International marks the first family cord blood bank to release results concerning ...
(Date:3/13/2020)... ... March 13, 2020 , ... Acumed LLC today ... the exclusive distributor of the Louisville-based company’s orthobiologics portfolio. Under the terms of ... distribute Vivorte’s calcium phosphate-based bone allograft (Trabexus) and calcium phosphate-based biocement (Fortera). Vivorte ...
(Date:3/11/2020)... ... March 11, 2020 , ... ... sensing, today announced smart human body temperature infrared touch-free monitoring product family, a ... meter WxS x800-IRTM, supporting flexible wireless uplink for cloud connectivity such as NB-IoT, ...
Breaking Biology News(10 mins):
(Date:3/4/2020)... ... March 04, 2020 , ... ... products and services, today announced the launch of its FleXpress™ high-throughput recombinant ... large number of antibodies at 80 ml scale. All production occurs in ...
(Date:2/28/2020)... ... 26, 2020 , ... Designed primarily for laboratory and industrial ... controller, thus simplifying setup, streamlining integration, and optimizing workflow. Capable of recording FHD ... Imaging’s new HS Series cameras to be released. The HS Series includes cameras ...
(Date:2/21/2020)... ... February 21, 2020 , ... Join Forrest Brown, Engineering Services Manager ... Sequence, Inc. for an informative session on Wednesday, February 26, 2020 ... elements to incorporate into facility design to add manufacturing flexibility in the future, especially ...
(Date:2/13/2020)... DUBLIN (PRWEB) , ... February 12, 2020 , ... ... affairs, and pharmacovigilance (PV) solutions and services, is adopting Veeva Vault Safety™ ... databases are a requirement for fast assessment of data, processing of safety information ...
Breaking Biology Technology:
Cached News: