HOME >> BIOLOGY >> NEWS
Sleep disorders linked to faulty brain chemistry, study finds

ANN ARBOR, Mich. The first tantalizing clues that chemical imbalances in the brain may be partly to blame for certain life-disrupting sleep disorders are being reported in two new studies by University of Michigan Health System researchers.

In two papers in the July 8 issue of the journal Neurology, the team reports apparent links between deficits in brain chemistry and obstructive sleep apnea (OSA) and REM sleep behavior disorder (RBD). Both are relatively common sleep problems that disturb the slumber -- and daytime behavior -- of millions of Americans.

The new findings were made using two types of neurochemical brain scans and detailed sleep studies in 13 patients with multiple system atrophy (MSA), a rare and fatal degenerative neurological disease almost always accompanied by severe sleep disorders. Their results from the MSA patients, who all had both sleep apnea and REM behavior disorder, were very different from those of 27 healthy control subjects.

Specifically, the researchers found that MSA patients had a far lower density of certain brain cells, or neurons, that produce the key chemicals dopamine and acetylcholine. The greater their lack, the worse their sleep problems were.

The patients with the fewest dopamine-producing neurons in the striatum of their brains had the worst RBD symptoms of thrashing, talking and violent flailing while they slept. And patients with the lowest levels of acetylcholine-producing neurons in the brainstem had the most interruptions in their breathing during sleep.

And while the researchers are careful to note that their findings to date can only show a correlation, not causation, between brain chemistry and sleep disorders, they plan further research to explore the relationship.

"It's exciting to be able to show this major neurochemical deficit for the first time, and confirm what others have suspected," says lead author Sid Gilman, M.D., F.R.C.P., the William J. Herdman Prof
'"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
7-Jul-2003


Page: 1 2 3 4 5

Related biology news :

1. Sleepless over Seattle: Migrating songbirds forgo sleep but keep their wits
2. Sleep boosts ability to learn language, University of Chicago researchers find
3. Sleep deprivation within five hours of learning impairs memory consolidation in mice
4. Sleep debts accrue when nightly sleep totals six hours or fewer
5. Sleepless aged rats show biological clock problems
6. Sleep in early life may play crucial role in brain development
7. Sleeping dogs lend a paw to narcoleptics
8. Protein Misfolding, Not Mutant Gene, Key To Lethal Sleep Disorder
9. Scientists Identify New Gene That Controls Sleep/Wake Cycle
10. Hibernation: The Opposite of Sleep?
11. Brain serotonin enzyme finding might explain psychiatric disorders

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2017)... 4, 2017   EyeLock LLC , a leader ... United States Patent and Trademark Office (USPTO) has issued ... linking of an iris image with a face image ... the company,s 45 th issued patent. ... timely given the multi-modal biometric capabilities that have recently ...
(Date:3/30/2017)... Trends, opportunities and forecast in this market ... (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, vein ... use industry (government and law enforcement, commercial and retail, ... others), and by region ( North America ... Pacific , and the Rest of the World) ...
(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... JULABO USA introduces its ... new website makes it easy to navigate through the site whether you’re in ... detailed product information, educational industry content and visit the company’s social media accounts, ...
(Date:8/14/2017)... ... August 14, 2017 , ... The Conference Forum has confirmed ... take place on September 6, 2017 at the Marriott Copley Place in Boston, MA. ... Medicine, Informatics, and Regulatory Strategy, Pfizer Innovative Research Lab, Pfizer, who leads 19 industry ...
(Date:8/11/2017)... ... 2017 , ... Algenist continues to disrupt the skincare industry with today’s debut ... , Collagen is the key structural element skin needs to maintain its youthful appearance ... First to market with proprietary collagen water active , ...
(Date:8/10/2017)... ... 09, 2017 , ... Teachers from three Philadelphia middle schools ... through the 16th, the University City Science Center will kick off the second ... Philadelphia-based middle school educators an opportunity for professional development related to STEM education. ...
Breaking Biology Technology:
Cached News: