HOME >> BIOLOGY >> NEWS
Sleep disorders linked to faulty brain chemistry, study finds

ANN ARBOR, Mich. The first tantalizing clues that chemical imbalances in the brain may be partly to blame for certain life-disrupting sleep disorders are being reported in two new studies by University of Michigan Health System researchers.

In two papers in the July 8 issue of the journal Neurology, the team reports apparent links between deficits in brain chemistry and obstructive sleep apnea (OSA) and REM sleep behavior disorder (RBD). Both are relatively common sleep problems that disturb the slumber -- and daytime behavior -- of millions of Americans.

The new findings were made using two types of neurochemical brain scans and detailed sleep studies in 13 patients with multiple system atrophy (MSA), a rare and fatal degenerative neurological disease almost always accompanied by severe sleep disorders. Their results from the MSA patients, who all had both sleep apnea and REM behavior disorder, were very different from those of 27 healthy control subjects.

Specifically, the researchers found that MSA patients had a far lower density of certain brain cells, or neurons, that produce the key chemicals dopamine and acetylcholine. The greater their lack, the worse their sleep problems were.

The patients with the fewest dopamine-producing neurons in the striatum of their brains had the worst RBD symptoms of thrashing, talking and violent flailing while they slept. And patients with the lowest levels of acetylcholine-producing neurons in the brainstem had the most interruptions in their breathing during sleep.

And while the researchers are careful to note that their findings to date can only show a correlation, not causation, between brain chemistry and sleep disorders, they plan further research to explore the relationship.

"It's exciting to be able to show this major neurochemical deficit for the first time, and confirm what others have suspected," says lead author Sid Gilman, M.D., F.R.C.P., the William J. Herdman Prof
'"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
7-Jul-2003


Page: 1 2 3 4 5

Related biology news :

1. Sleepless over Seattle: Migrating songbirds forgo sleep but keep their wits
2. Sleep boosts ability to learn language, University of Chicago researchers find
3. Sleep deprivation within five hours of learning impairs memory consolidation in mice
4. Sleep debts accrue when nightly sleep totals six hours or fewer
5. Sleepless aged rats show biological clock problems
6. Sleep in early life may play crucial role in brain development
7. Sleeping dogs lend a paw to narcoleptics
8. Protein Misfolding, Not Mutant Gene, Key To Lethal Sleep Disorder
9. Scientists Identify New Gene That Controls Sleep/Wake Cycle
10. Hibernation: The Opposite of Sleep?
11. Brain serotonin enzyme finding might explain psychiatric disorders

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Sleep disorders linked faulty brain chemistry study finds

(Date:7/23/2014)... Ind. Spinach gave Popeye super strength, but it ... a group of scientists: the ability to convert sunlight ... physicists are part of an international group using spinach ... by which plants convert the sun,s energy into carbohydrates ... study are part of the most efficient system ever ...
(Date:7/23/2014)... , , , ... , , , , ... lifespan. The idea, they argue, would be to target the... , , ... , , , , ... , , , , , , , Medicine focuses almost entirely on ...
(Date:7/23/2014)... its grip is affecting more than the color of people,s ... a heat-loving amoeba commonly found in warm freshwater bodies, such ... made warmer than usual this year. , A 9-year-old Kansas ... after swimming in several area lakes. The amoeba enters the ... the brain. Nose plugs can lower the odds of this ...
Breaking Biology News(10 mins):Spinach could lead to alternative energy more powerful than Popeye 2Strategy proposed for preventing diseases of aging 2Strategy proposed for preventing diseases of aging 3Strategy proposed for preventing diseases of aging 4Strategy proposed for preventing diseases of aging 5Diseases of another kind 2
(Date:7/23/2014)... , July 23, 2014  Having the right people ... vital to accelerating business growth and achieving clinical and ... Association (AHA) Leadership Summit, July 20-22, 2014, in ... of hospital executives and healthcare experts discussing how partnerships ... Carrocino , President & Chief Executive Officer of Cape ...
(Date:7/23/2014)... StemGenex® , the leading resource for ... at improving the lives of patients dealing with degenerative ... disease. StemGenex believes that a commitment to the ... when providing care to patients with degenerative diseases. ... accessible to the millions of individuals currently living with ...
(Date:7/23/2014)... Iowa (PRWEB) July 23, 2014 DuPont ... the business as vice president of Agricultural Biotechnology (ABT), ... Biotechnology where he served most recently as president, chief ... biotechnology and business leadership in the seed and crop ... said Paul E. Schickler , president of DuPont ...
(Date:7/23/2014)... -- regulated information -- UCB today announced an important ... positive topline results from the latest Phase 3 ... to evaluate the efficacy and safety of ... compared to placebo, as adjunctive treatment in adult ... controlled despite treatment with one or two concomitant ...
Breaking Biology Technology:MSC and Cape Regional Medical Center Partner to Improve Cost, Quality and Outcomes 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 3DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7
Cached News: