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'Sloppy genes' behave like their neighbours

The inaugural issue of Journal of Biology features groundbreaking research that challenges the traditional view of how genes are controlled. Our current understanding of gene expression, the fundamental process by which proteins are made from the instructions encoded in DNA, is that the process is tightly controlled so that the correct amount of each protein is produced in the right place at the right time. The new research, by Paul Spellman and Gerald Rubin of Howard Hughes Medical Institute and University of California Berkeley, indicates that some groups of around 15 genes that just happen to be located next to each other on chromosomes are instead routinely expressed together. Genes within a block are not related to one another by structure or function: they are simply neighbours within the genome. These conclusions were drawn from experiments using DNA-coated microarrays to monitor the expression of all the genes in the genome of the fruitfly.

Microarray experiments allow researchers to look at the expression of a large number of genes in a single experiment and ask which genes are being turned on (or expressed) in a particular cell type, at a certain time, under defined conditions. Spellman and Rubin analysed gene expression data from 88 independent microarray experiments using DNA extracted from the fruitfly, Drosophila melanogaster. Then instead of the usual practice of searching the microarray data for groups of genes that showed similar expression profiles, they arranged the expression data in the order in which the genes occur along the flys chromosomes.

To their surprise, Spellman and Rubin found over 200 large groups of adjacent and similarly expressed genes. Each of these groups contained between 10 and 30 genes, and together the groups accounted for approximately 20% of the genes in the flys genome. This suggests that there is a previously unsuspected mechanism of regulating of gene expression, which works on blocks of genes depending
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Contact: Gordon Fletcher
gordon@biomedcentral.com
44-20-7323-0323
BioMed Central
18-Jun-2002


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