HOME >> BIOLOGY >> NEWS
Small G-Proteins Make A Big Difference -- Nerve Cell Signalling Is Regulated By,,Arf-GTPases And Their Activators

Researchers at the Max Planck Institutes for Biophysical Chemistry and for Experimental Medicine in Göttingen/Germany discovered a new regulatory process through which nerve cells modulate the release of neurotransmitter in the brain (Proc. Natl. Acad. Sci. U.S.A. 96, 1094-1099; Feb. 2, 1999).

Information in the brain is transmitted at synapses which are specialized contact zones between a sending and a receiving nerve cell. When stimulated, the sending nerve cell releases signalling molecules. These so called neurotransmitters diffuse to the receiving nerve cell where they activate surface receptors that in turn change the physiological state of the receiving cell and thereby transmit the synaptic signal.

Transmitter release at synapses is a complex process. It involves a large number of proteins which regulate the turnover of synaptic vesicles, small membranous intracellular organelles that store neurotransmitter and release it upon stimulation by fusing with the cell membrane. In a nerve cell, synaptic vesicles pass through a sophisticated cycle of fusion and budding reactions, and the efficiency of these reactions determines the vesicle supply that is ready for transmitter release at any moment in time.

Uri Ashery and Volker Scheuss in the laboratory of Jens Rettig at the Max Planck Institute for Biophysical Chemistry, Göttingen/Germany, used a new method to identify two novel regulators of the synaptic vesicle cycle. In collaboration with Henriette Koch and Nils Brose, head of a research group at the Max Planck Institute for Experimental Medicine in Göttingen/Germany, they expressed the protein msec7-1 in neuromuscular synapses of Xenopus frogs. msec7-1 is an activator of members of the Arf-family of small GTPases. Both msec7-1 and Arfs are very prominent regulators of membrane transport in the Golgi apparatus of all cells in the body. The Göttingen group discovered that the msec7/Arf-system plays an as yet unrecognized
'"/>

Contact: Jens Rettig, Nils Brose
jrettig@gwdg.de
49-551-3899-725
Max-Planck-Gesellschaft
2-Feb-1999


Page: 1 2

Related biology news :

1. Small, Smac-like molecule encourages death of cancer cells
2. Small animal imaging gives cancer clues
3. Small RNA surmounts large cancer problem
4. Small, cold, & hungry: Ultra-small microbes from 120,000-year-old glacier ice sample
5. Small trial shows daclizumab add-on therapy improves MS outcome
6. Small gene changes in some leukemia patients may explain varying responses to chemotherapy
7. Small amounts of alcohol or anesthetics may damage the developing brain
8. Smallpox in 50-year-old tissues detected by integrated diagnostics approach
9. Small-molecule inhibitors of anthrax lethal factor identified
10. Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection
11. Small-molecule inhibitors of botulinum neurotoxin identified

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: