HOME >> BIOLOGY >> NEWS
Small RNA surmounts large cancer problem

Many potentially effective cancer treatments are undone by the onset of resistance to the treatment. In order to circumvent this problem, D. Gary Gilliland and colleagues, of Brigham and Women's Hospital, have developed a strategy using the latest technologies involving small interfering RNA to enhance cancer treatment even in a situation where drug resistance has developed. Small interfering RNAs work by inhibiting the expression of specific genes that have a matching complimentary sequence. The authors theorized that this type of RNA treatment might boost the effectiveness of anti-cancer treatments. They tested their theory in a form of leukemia that is caused when two genes fuse to form an unregulated gene that transforms normal cells into cancer cells, a gene called TEL-PDGFbetaR. This form of leukemia is generally treated with a commonly used anti-cancer drug called imatinib, which is a small molecule protein inhibitor that blocks the activity of the protein produced from the fusion gene TEL-PDGFbetaR. Gilliland and colleagues created a small inhibitory RNA specific to the TEL-PDGFbetaR fusion gene, and found that its expression did indeed exclusively reduce the expression of the oncogenic TEL-PDGFbetaR by 90%. While this alone was not sufficient to kill the cancer cells, this treatment enhanced the ability of imatinib to kill these cancer cells. Further, when they tested this strategy with imatinib-resistant cells, the inhibitory RNA was still able to reduce this gene's expression, and enhanced the activity of another small molecule inhibitor. This study demonstrates that small inhibitory RNA treatment may be an extremely useful adjunct to cancer treatments, and can also aid in overcoming the common problem of drug resistance when used in conjunction with anticancer agents.


'"/>

Contact: Laurie Goodman
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
15-Jun-2004


Page: 1

Related biology news :

1. Small, Smac-like molecule encourages death of cancer cells
2. Small animal imaging gives cancer clues
3. Small, cold, & hungry: Ultra-small microbes from 120,000-year-old glacier ice sample
4. Small trial shows daclizumab add-on therapy improves MS outcome
5. Small gene changes in some leukemia patients may explain varying responses to chemotherapy
6. Small amounts of alcohol or anesthetics may damage the developing brain
7. Smallpox in 50-year-old tissues detected by integrated diagnostics approach
8. Small-molecule inhibitors of anthrax lethal factor identified
9. Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection
10. Small-molecule inhibitors of botulinum neurotoxin identified
11. Smallest whirlpools can pack stunningly strong force

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... ... Gateway Genomics , a leading developer of direct-to-consumer genetic tests that ... Inc. 500|5000 list of fastest growing private companies, in the first year the ... generating revenue by March 31, 2015. Ranking in the list is determined by the ...
(Date:8/14/2019)... ... ... Julie Reck of Veterinary Medical Center of Fort Mill has recently begun providing ... her own geriatric Australian Shepherd, Simon, was treated in June 2019 for osteoarthritis in his ... body was weak, and he struggled to play fetch and other games with his family. ...
(Date:8/6/2019)... N.C. (PRWEB) , ... August 06, 2019 , ... ... (SCTM) identifies a computational modeling system that could have far-reaching implications for personalized ... partial least squares regression (PLSR), is able to predict which stem cell donors ...
Breaking Biology News(10 mins):
(Date:8/7/2019)... Ohio (PRWEB) , ... August 07, 2019 , ... Locus ... a breakthrough line of soil amendments (soil “probiotics”), including Rhizolizer ® , which ... a year—the largest impact any approach has offered to date. Results from the treatment ...
(Date:8/6/2019)... EDWARDSVILLE, Ill. (PRWEB) , ... August 06, 2019 ... ... to Southern Illinois University Edwardsville for the launch of a community project that ... , The three-year grant supports the project, entitled “A Youth-Led Citizen Science Network ...
(Date:7/23/2019)... , ... July 22, 2019 , ... ... companies with best-in-class services in the fields of 3D tissue imaging , ... learning , Visikol initially started back in 2013 as a products company. These ...
(Date:7/17/2019)... N.J. (PRWEB) , ... July ... ... announced a long-term strategic agreement for the development and manufacturing of Zolgensma® ... , Through this collaboration, AveXis, a Novartis company, will have dedicated manufacturing ...
Breaking Biology Technology:
Cached News: