Small animal imaging gives cancer clues

Advances in biomedical imaging are allowing UC Davis researchers to use mice more effectively to study cancers comparable to human disease. The system can distinguish different stages of cancer and could lead to more sensitive screening tests for cancer-fighting drugs.

Positron emission tomography (PET) is widely used for detecting and following cancer in human patients. It works by following short-lived radioactive tracers that are taken up by fast-growing cancer cells.

PET scanners used for humans don't have the resolution to image an animal as small as a mouse. Researchers led by Simon Cherry, a professor of biomedical engineering at UC Davis, have developed a PET scanner sensitive enough to use with mice, and Craig Abbey, also in the Department of Biomedical Engineering, has developed image analysis methods to use the scanner to monitor tumors.

They're working with cancer researchers Alexander Borowsky, Robert Cardiff and Jeffrey Gregg at the UC Davis Center for Comparative Medicine to study cancerous growths in mice similar to ductal carcinoma in situ (DCIS), a precursor to breast cancer in humans.

"With non-invasive imaging, we can follow the development of disease in one mouse over a long time period," Abbey said. The method is also more sensitive to changes in cancer growth, making it possible to look for small treatment effects.

Most invasive breast cancers are thought to develop from DCIS, and standard care is to remove the entire area involved, Borowsky said. Based on the appearance of a DCIS under the microscope, doctors can estimate how quickly it could become a more aggressive, invasive form if not completely removed, he said. The new PET technology allows researchers to follow the same changes in a mouse without surgery.

"Not only can we see the DCIS-like lesion, but we can detect the earliest transition to an invasive tumor," Borowsky said. The model

Contact: Andy Fell
University of California - Davis

Page: 1 2

Related biology news :

1. Small, Smac-like molecule encourages death of cancer cells
2. Small RNA surmounts large cancer problem
3. Small, cold, & hungry: Ultra-small microbes from 120,000-year-old glacier ice sample
4. Small trial shows daclizumab add-on therapy improves MS outcome
5. Small gene changes in some leukemia patients may explain varying responses to chemotherapy
6. Small amounts of alcohol or anesthetics may damage the developing brain
7. Smallpox in 50-year-old tissues detected by integrated diagnostics approach
8. Small-molecule inhibitors of anthrax lethal factor identified
9. Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection
10. Small-molecule inhibitors of botulinum neurotoxin identified
11. Smallest whirlpools can pack stunningly strong force

Post Your Comments:
TAG: Small animal imaging gives cancer clues

(Date:10/5/2015)... -- http://soundview.co ) releases the ... NXTD ), a biometric authentication company focused on ... ) releases the following market and company ... biometric authentication company focused on the growing mobile commerce ... ) releases the following market and company ...
(Date:9/30/2015)... , Sept. 30, 2015  The global glucose monitoring device ... 2015. So says a new report on the industry from ... segment dominate the market, followed by continuous glucose monitoring and ... on the market for these products in its latest report, ... , ...
(Date:9/28/2015)... 28, 2015 The global ... USD 12.03 billion by 2020, growing at a CAGR ... as Backside Illumination (BSI) technique to improve picture quality ... period.      (Logo: http://photos.prnewswire.com/prnh/20150105/723757) , ... to reduce loss and, thus, reduce the noise interference ...
Breaking Biology News(10 mins):
(Date:10/8/2015)... BALTIMORE, Maryland , October 8, 2015 /PRNewswire/ ... http://www.GoldmanResearch.com .   --> Goldman ... specializing in the small cap and microcap sectors, ... sponsored research report on PharmaCyte Biotech, Inc. (OTCQB ... company focused on developing and preparing treatments for ...
(Date:10/8/2015)... 8, 2015  The ALS Association, in partnership with ... Challenge to revolutionize communication technology solutions for people living ... ALS (amyotrophic lateral sclerosis) is a progressive neurodegenerative ... and the spinal cord. Eventually, people with ALS lose ... often leads to total paralysis and death within two ...
(Date:10/8/2015)... ... , ... Talon Innovations, a provider of Precision Machined Products and ... is one of three finalists for the Minnesota Business magazine’s Manufacturing Award in the ... Innovations was recognized as a nominee for this competitive award. , The “Best ...
(Date:10/7/2015)... 7, 2015 Boston Scientific (NYSE: ... the Boston Scientific Connected Patient Challenge , an ... use of remote patient monitoring to enhance patient care.  ... can submit their ideas and collaborate on solutions through ... Cambridge, MA where they ...
Breaking Biology Technology:
Cached News: