Small animal imaging gives cancer clues

Advances in biomedical imaging are allowing UC Davis researchers to use mice more effectively to study cancers comparable to human disease. The system can distinguish different stages of cancer and could lead to more sensitive screening tests for cancer-fighting drugs.

Positron emission tomography (PET) is widely used for detecting and following cancer in human patients. It works by following short-lived radioactive tracers that are taken up by fast-growing cancer cells.

PET scanners used for humans don't have the resolution to image an animal as small as a mouse. Researchers led by Simon Cherry, a professor of biomedical engineering at UC Davis, have developed a PET scanner sensitive enough to use with mice, and Craig Abbey, also in the Department of Biomedical Engineering, has developed image analysis methods to use the scanner to monitor tumors.

They're working with cancer researchers Alexander Borowsky, Robert Cardiff and Jeffrey Gregg at the UC Davis Center for Comparative Medicine to study cancerous growths in mice similar to ductal carcinoma in situ (DCIS), a precursor to breast cancer in humans.

"With non-invasive imaging, we can follow the development of disease in one mouse over a long time period," Abbey said. The method is also more sensitive to changes in cancer growth, making it possible to look for small treatment effects.

Most invasive breast cancers are thought to develop from DCIS, and standard care is to remove the entire area involved, Borowsky said. Based on the appearance of a DCIS under the microscope, doctors can estimate how quickly it could become a more aggressive, invasive form if not completely removed, he said. The new PET technology allows researchers to follow the same changes in a mouse without surgery.

"Not only can we see the DCIS-like lesion, but we can detect the earliest transition to an invasive tumor," Borowsky said. The model

Contact: Andy Fell
University of California - Davis

Page: 1 2

Related biology news :

1. Small, Smac-like molecule encourages death of cancer cells
2. Small RNA surmounts large cancer problem
3. Small, cold, & hungry: Ultra-small microbes from 120,000-year-old glacier ice sample
4. Small trial shows daclizumab add-on therapy improves MS outcome
5. Small gene changes in some leukemia patients may explain varying responses to chemotherapy
6. Small amounts of alcohol or anesthetics may damage the developing brain
7. Smallpox in 50-year-old tissues detected by integrated diagnostics approach
8. Small-molecule inhibitors of anthrax lethal factor identified
9. Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection
10. Small-molecule inhibitors of botulinum neurotoxin identified
11. Smallest whirlpools can pack stunningly strong force

Post Your Comments:

(Date:4/13/2016)... April 13, 2016  IMPOWER physicians supporting Medicaid patients ... a new clinical standard in telehealth thanks to a ... the higi platform, IMPOWER patients can routinely track key ... body mass index, and, when they opt in, share ... visit to a local retail location at no cost. ...
(Date:3/31/2016)... 2016  Genomics firm Nabsys has completed a financial ... Bready , M.D., who returned to the company in ... leadership team, including Chief Technology Officer, John Oliver ... Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys from ...
(Date:3/23/2016)... 2016 Einzigartige ... und Stimmerkennung mit Passwörtern     ... MESG ), ein führender Anbieter digitaler Kommunikationsdienste, ... SpeechPro zusammenarbeitet, um erstmals dessen Biometrietechnologie einzusetzen. ... Möglichkeit angeboten, im Rahmen mobiler Apps neben ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... on a range of subjects including policies, debt and investment ... Speaking at a lecture to the Canadian Economics ... the country,s inflation target, which is set by both the ... "In certain areas there needs to be frequent ... not sit down and address strategy together?" He ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a leader in ... Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, Mosio ... practical tips, tools, and strategies for clinical researchers. , “The landscape of how ...
(Date:6/23/2016)... , June 23, 2016 A person commits a ... crime scene to track the criminal down. An ... Food and Drug Administration (FDA) uses DNA evidence to track ... Sound far-fetched? It,s not. The FDA has increasingly ... support investigations of foodborne illnesses. Put as simply as possible, ...
(Date:6/23/2016)... YORK , June, 23, 2016  The Biodesign ... to envision new ways to harness living systems and ... Modern Art (MoMA) in New York City ... than 130 participating students, showcased projects at MoMA,s Celeste ... Paola Antonelli , MoMA,s senior curator of architecture ...
Breaking Biology Technology:
Cached News: