HOME >> BIOLOGY >> NEWS
Small animal imaging gives cancer clues

Advances in biomedical imaging are allowing UC Davis researchers to use mice more effectively to study cancers comparable to human disease. The system can distinguish different stages of cancer and could lead to more sensitive screening tests for cancer-fighting drugs.

Positron emission tomography (PET) is widely used for detecting and following cancer in human patients. It works by following short-lived radioactive tracers that are taken up by fast-growing cancer cells.

PET scanners used for humans don't have the resolution to image an animal as small as a mouse. Researchers led by Simon Cherry, a professor of biomedical engineering at UC Davis, have developed a PET scanner sensitive enough to use with mice, and Craig Abbey, also in the Department of Biomedical Engineering, has developed image analysis methods to use the scanner to monitor tumors.

They're working with cancer researchers Alexander Borowsky, Robert Cardiff and Jeffrey Gregg at the UC Davis Center for Comparative Medicine to study cancerous growths in mice similar to ductal carcinoma in situ (DCIS), a precursor to breast cancer in humans.

"With non-invasive imaging, we can follow the development of disease in one mouse over a long time period," Abbey said. The method is also more sensitive to changes in cancer growth, making it possible to look for small treatment effects.

Most invasive breast cancers are thought to develop from DCIS, and standard care is to remove the entire area involved, Borowsky said. Based on the appearance of a DCIS under the microscope, doctors can estimate how quickly it could become a more aggressive, invasive form if not completely removed, he said. The new PET technology allows researchers to follow the same changes in a mouse without surgery.

"Not only can we see the DCIS-like lesion, but we can detect the earliest transition to an invasive tumor," Borowsky said. The model
'"/>

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
9-Aug-2004


Page: 1 2

Related biology news :

1. Small, Smac-like molecule encourages death of cancer cells
2. Small RNA surmounts large cancer problem
3. Small, cold, & hungry: Ultra-small microbes from 120,000-year-old glacier ice sample
4. Small trial shows daclizumab add-on therapy improves MS outcome
5. Small gene changes in some leukemia patients may explain varying responses to chemotherapy
6. Small amounts of alcohol or anesthetics may damage the developing brain
7. Smallpox in 50-year-old tissues detected by integrated diagnostics approach
8. Small-molecule inhibitors of anthrax lethal factor identified
9. Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection
10. Small-molecule inhibitors of botulinum neurotoxin identified
11. Smallest whirlpools can pack stunningly strong force

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/7/2017)... Feb. 7, 2017 Zimmer Biomet Holdings, Inc. ... healthcare, will present at the LEERINK Partners 6th Annual ... Hotel on Wednesday, February 15, 2017 at 10 a.m. ... the presentation can be accessed at http://wsw.com/webcast/leerink28/zbh .  ... conference via Zimmer Biomet,s Investor Relations website at ...
(Date:2/2/2017)... 2017   TapImmune, Inc. (NASDAQ: ... in the development of innovative peptide and gene-based ... and metastatic disease, announced today it has successfully ... a second clinical lot of TPIV 200, the ... The manufactured vaccine product will be used to ...
(Date:1/30/2017)...   Invitae Corporation (NYSE: NVTA ... today announced that it will report its fourth quarter ... on Monday, February 13, 2017, and Invitae,s management team ... p.m. Eastern / 1:45 p.m. Pacific. ... financial results, guidance, and recent developments and will spend ...
Breaking Biology News(10 mins):
(Date:2/27/2017)... and HAMILTON, Bermuda , Feb. ... ADXS ) and SELLAS Life ... on developing cancer immunotherapies, today announced that Advaxis ... novel cancer immunotherapy agent using Advaxis, proprietary ... WT1 targeted heteroclitic peptide antigen mixture (galinpepimut-S). ...
(Date:2/25/2017)... (PRWEB) , ... February 25, 2017 , ... ... Verified Clinical Trials in an ongoing effort to create meaningful change ... advocacy, and pharmaceutical research with emphasis on consumers and patients’ mental health well-being. ...
(Date:2/24/2017)...  Aethlon Medical, Inc. (Nasdaq: AEMD ), ... and CEO, Jim Joyce . In ... Saturday, Bill Gates warned world leaders that ... nuclear weapons. Mr. Gates expressed his concern, which is ... scientific terrorists have access to the necessary tools to ...
(Date:2/24/2017)... 2017 China Biologic Products, Inc. (NASDAQ: CBPO) ("China ... company in China, today announced its financial results for the ... Fourth Quarter 2016 Financial Highlights Total ... in RMB terms, or increased by 13.6% in USD terms ... of 2015. Gross profit increased by 13.3% ...
Breaking Biology Technology:
Cached News: