HOME >> BIOLOGY >> NEWS
Small-molecule inhibitors of botulinum neurotoxin identified

Scientists have identified several key molecules that block the activity of a toxin that causes botulism--an important first step in developing therapeutics to counter the disease.

Botulinum neurotoxins (BoNT) are useful as therapeutic agents for treating a wide variety of muscle dysfunctions in humans, and are used cosmetically to reduce wrinkles. Paradoxically, the seven serotypes of BoNT, designated A through G, also are among the most lethal biological substances known.

Botulinum neurotoxins are composed of two peptide chains, a heavy chain (HC) and a light chain (LC). The heavy chain targets and binds to surface receptors on nerve terminals. The toxins are then internalized into the nerve terminal. Once inside, the light chain separates from the heavy chain and cleaves, or cuts, specific proteins that control neuromuscular function. Cleavage of these proteins effectively blocks the release of neurotransmitters that cause the muscle contractions necessary for respiration. The result is a flaccid paralysis that ultimately leads to suffocation and death.

Because botulinum neurotoxins are capable of causing mass casualties, they are classified as biodefense A (top priority) agents by the Centers for Disease Control and Prevention. Currently, no therapeutics exist to counter the threat; thus, identifying and developing compounds that inhibit the neurotoxins is a high priority.

In an article published last month in Biochemical and Biophysical Research Communications, and recently highlighted in Nature Reviews in Drug Discovery, investigators from the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), the National Cancer Institute (NCI), and the University of Nebraska Medical Center (UNMC) report using a high-throughput assay to screen a group of 1,990 compounds known as the NCI diversity set. The molecular properties of this group are predictive of a larger set of more than 100,000 compounds. '"/>

Contact: Caree Vander Linden
Caree.Vander-Linden@amedd.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
13-Nov-2003


Page: 1 2

Related biology news :

1. Small-molecule inhibitors of anthrax lethal factor identified
2. Chemical genetics identifies SARS inhibitors
3. COX-2 inhibitors and renal damage in obesity-related Type II diabetes
4. Researchers learn certain enzyme inhibitors may help in cancer therapy following initial procedures
5. Study offers new insights into angiogenesis inhibitors
6. COX-2 inhibitors may delay onset of breast cancer
7. Harvard Medical School researchers discover first in a new class of mitosis inhibitors
8. Rare childhood genetic syndrome identified
9. Newly identified master gene key in babys first breath
10. Key stimulator of colorectal cancer identified
11. New anti-inflammatory strategy for cancer therapy identified by UCSD researchers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2019)... ... June 25, 2019 , ... ... Using 23andMe raw data, easily available from 23andMe, customers can get access to ... service is available for both 23andMe Ancestry and Health + Ancestry customers., With ...
(Date:6/16/2019)... , ... June 14, 2019 , ... ... invited to lecture at the fifth annual Neodent World Congress. Attended by thousands ... innovative progress and latest advancements in the world of dentistry. The three-day event ...
(Date:6/11/2019)... ... June 12, 2019 , ... With a rapidly growing ... leverage the Geneious Biologics platform as a premium hub for bioinformatics and computer ... says: “The Geneious team has done an excellent job accommodating our specific data, ...
Breaking Biology News(10 mins):
(Date:6/12/2019)... EGG HARBOR TOWNSHIP, N.J. (PRWEB) , ... June ... ... premier manufacturer of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, ... partnership agreement with Shanghai Zillion has been signed. The agreement will grant exclusive ...
(Date:6/11/2019)... CITY, Calif. (PRWEB) , ... June 10, 2019 ... ... (IOPP) today announced IOPP will add 80 of its scientific journals to DeepDyve’s ... of physics-related content to DeepDyve’s continually expanding library of more than 20 million ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study released ... cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their gene ... MSC-EVs also increased the cells’ ability to lodge into bone marrow. This research ...
(Date:5/31/2019)... (PRWEB) , ... May 29, ... ... our patent applications from the USPTO providing proprietary interest to our methodology, ... FOR SLEEP DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our ...
Breaking Biology Technology:
Cached News: