HOME >> BIOLOGY >> NEWS
Small molecules used to block proteins in HIV

WEST LAFAYETTE, Ind. -- Taking a cue from the Biblical story of David and Goliath, Purdue University scientists are using small molecules to bring down the molecular giants responsible for viral replication in AIDS.

The new approach blocks the interaction of two identical proteins that make up HIV protease by strategically slinging small molecules between key segments on the proteins as they come together to form an enzyme needed for viral replication. HIV protease is one of three essential enzymes used by the AIDS virus to replicate.

By targeting the site where the proteins come together, the small molecules can serve as a "molecular wedge" to prevent the proteins from interacting, thus thwarting the chain of chemical reactions needed to replicate, says Jean Chmielewski (she-ma-LEW-ski), associate professor of chemistry at Purdue who is a pioneer in the new approach.

"Theoretically, if you can stop the proteins from coming together and performing their biological activity, you'll stop viral replication," she says.

The method is currently being tested at the National Institutes of Health in cells infected with HIV, the virus that causes AIDS. If the studies prove successful, the general approach may someday be used to treat a wide range of diseases and disorders, including some currently untreatable conditions such as autoimmune diseases.

"At this stage, we've been able to synthesize some fairly potent small-molecule inhibitors of HIV protease, which do, in fact, block the ability of this enzyme to come together," Chmielewski says. "That, in turn, blocks its biological activity."

Chmielewski will present details of the new method Sunday (8/20) at the American Chemical Society's national meeting in Washington, D.C.

The new approach is based on the fact that an individual protein usually must work in conjunction with other proteins to carry out vital functions within a cell.

"There are a lot of disease states that are perpetuated b
'"/>

Contact: Susan Gaidos
sgaidos@uns.purdue.edu
765-494-2081
Purdue University
19-Aug-2000


Page: 1 2 3

Related biology news :

1. Small, Smac-like molecule encourages death of cancer cells
2. Small animal imaging gives cancer clues
3. Small RNA surmounts large cancer problem
4. Small, cold, & hungry: Ultra-small microbes from 120,000-year-old glacier ice sample
5. Small trial shows daclizumab add-on therapy improves MS outcome
6. Small gene changes in some leukemia patients may explain varying responses to chemotherapy
7. Small amounts of alcohol or anesthetics may damage the developing brain
8. Smallpox in 50-year-old tissues detected by integrated diagnostics approach
9. Small-molecule inhibitors of anthrax lethal factor identified
10. Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection
11. Small-molecule inhibitors of botulinum neurotoxin identified

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: