HOME >> BIOLOGY >> NEWS
Small subset of cells has big role in controlling immunity, study finds

A small subset of cells that tells the immune system whether to attack may be a future target for therapies to help patients fight tumors and keep transplanted organs, a Medical College of Georgia researcher says.

Dendritic cells roam the body, picking up invaders, such as a virus or cancer, then show their finds to the T-cells and tell them how to respond, says Dr. Andrew L. Mellor, molecular geneticist and immunologist and director of the MCG Immunotherapy Center.

Work published in the Aug. 15 issue of The Journal of Immunology by Dr. Mellor and his colleagues gives further clues over what direction dendritic cells will give.

They have shown that giving mice an experimental immunosuppressive agent causes a select number of these cells to express an enzyme, indoleamine 2,3 dioxygenase, or IDO, and that those cells tell T-cells not to respond.

"They are a very fascinating new subset of dendritic cells previously not recognized," says Dr. Mellor, Georgia Research Alliance Eminent Scholar in Molecular Immunogenetics. "We do not think all dendritic cells have the capacity to express IDO. The magic of this subset is their ability to do that," he said of the enzyme first identified for its role in helping a fetus escape rejection by the mother's immune system.

"One of the things we argue in this paper is that we can use IDO to help us find out if dendritic cells are going to stimulate the immune system or turn it off. If they express IDO, they will not stimulate T cells to respond. If they don't express IDO, they are likely to stimulate immune responses once they mature," Dr. Mellor says.

Five years ago nearly to the day, Dr. Mellor and his colleagues, Drs. David Munn and Simon Conway, were reporting in the journal Science that the developing fetus uses IDO to locally disable the mother's immune system. It works by degrading tryptophan, an amino acid critical to the survival of T-cells, which get their action cues from d
'"/>

Contact: Toni Baker
tbaker@mail.mcg.edu
706-721-4421
Medical College of Georgia
15-Aug-2003


Page: 1 2 3 4

Related biology news :

1. Small, Smac-like molecule encourages death of cancer cells
2. Small animal imaging gives cancer clues
3. Small RNA surmounts large cancer problem
4. Small, cold, & hungry: Ultra-small microbes from 120,000-year-old glacier ice sample
5. Small trial shows daclizumab add-on therapy improves MS outcome
6. Small gene changes in some leukemia patients may explain varying responses to chemotherapy
7. Small amounts of alcohol or anesthetics may damage the developing brain
8. Smallpox in 50-year-old tissues detected by integrated diagnostics approach
9. Small-molecule inhibitors of anthrax lethal factor identified
10. Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection
11. Small-molecule inhibitors of botulinum neurotoxin identified

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Small subset cells has big role controlling immunity study finds

(Date:10/25/2014)...   MedNet Solutions , a global life sciences ... pleased to announce the 2014 iMedNet User ... held in Bloomington, Minnesota on ... attendance and promises to be informative, productive and enjoyable ... the meeting is iMedNet™ EDC , ...
(Date:10/25/2014)... , Oct. 22, 2014 This report ... a relatively new space in heavy pursuit of research ... unique to miRNAs compared to other RNA components. miRNA,s ... it a novel candidate for use as a biomarker ... of miRNA-based microarrays and diagnostics for the advancement in ...
(Date:10/25/2014)... -- A recent report, "Genetic Testing Market Outlook 2018", ... genetic testing market. A comprehensive introduction of gene-based tests, ... report. On account of our analysis of the past ... challenges; forecast for genetic testing has been drawn, according ... a CAGR of around 9% during 2013-2018. Our ...
Breaking Biology News(10 mins):MedNet Solutions To Host Third Annual iMedNet User Group Meeting 2MicroRNA: An Insight to miRNA-based microarrays, diagnostics and therapeutics Overview, Cambridge Healthtech Advisors 2Genetic Testing Market Outlook 2018 2
(Date:10/25/2014)... NEW YORK , Oct. 24, ... formerly Access Pharmaceuticals, Inc. (ACCP), a biopharmaceutical company ... has implemented a 1-for-50 reverse split of its ... on Friday, October 24, 2014. PlasmaTech,s common stock ... CUSIP number 72754H109 and temporary ticker symbol "ACCPD". ...
(Date:10/25/2014)... 24, 2014 ... has announced the addition of the  "The ... Other 2-D Nanomaterials "  report to their ... ,CNTs and graphene are the strongest, lightest ... with a performance-per-weight greater than any other ...
(Date:10/22/2014)... The Americas Inorganic Refrigerants Market ... in Americas with analysis and forecast of revenue. ... Inorganic Refrigerants Market report, to get an idea ... a glimpse of the segmentation in the Americas ... tables and figures. , http://www.micromarketmonitor.com/market/americas-inorganic-refrigerants-4191654241.html ...
(Date:10/22/2014)... NJ (PRWEB) October 22, 2014 ... and services – has been working with a team ... and New Haven Farms Community Farming Collaborative to provide ... ePRO solution. The study, which started in May, ... program that provides participants weekly exposure to and participation ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 3The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 4The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3
Cached News: