HOME >> BIOLOGY >> NEWS
Smallpox in 50-year-old tissues detected by integrated diagnostics approach

A rare, preserved specimen of human tissue infected with Variola virus, the causative agent of smallpox, has given scientists the unique opportunity to test modern diagnostic capabilities for the virus.

Smallpox, a devastating disease, was eradicated in 1979 through the efforts of the World Health Organization (WHO). Currently, infectious Variola (a species of the genus Orthopoxvirus) is known to exist only in two WHO-sanctioned repositories, one in Russia and the other at the Centers for Disease Control and Prevention in Atlanta. However, there is concern that undisclosed reference stocks of the virus may exist--and given its potential as a biological threat agent, improved methods of detection and identification are a high priority.

According to an article published in this month's issue of Laboratory Investigation, the specimen used in the study was part of a private collection archived at the Indiana University School of Dentistry. The university investigation determined the specimen--an intact forearm and hand, presumably from a child--to be about 50 years old. It was offered to the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) for further analysis.

"This was a unique chance for us to test all the assays and techniques that we had been working on for a potential biothreat agent--and to do it using a real sample of a disease that no longer occurs," said lead author Randal J. Schoepp. The USAMRIID team included Michelle D. Morin, Mark J. Martinez, David A. Kulesh, Lisa Hensley, Thomas W. Geisbert, and Peter B. Jahrling, with Daniel R. Brady of Indiana University also contributing to the study.

According to Schoepp, working with the specimen was a challenge. It had been maintained under less-than-ideal storage conditions, exposed to extremes of temperature, and preserved in fixative for decades. Nonetheless, it afforded an unparalleled opportunity to test a modern, integrated diagnostic approa
'"/>

Contact: Caree Vander Linden
Caree.Vander-Linden@amedd.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
29-Jan-2004


Page: 1 2

Related biology news :

1. Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection
2. Smallpox vaccination grinds to halt
3. CDC Telebriefing: Smallpox educational activities and West Nile Virus update
4. Smallpox vaccines
5. Single isolated mouse skin cell can generate into variety of epidermal tissues
6. Patented process preserves transplant tissues/organs
7. Growing replacement teeth and dental tissues
8. Making new muscle: Researchers in Rome produce a mouse that can regenerate its tissues
9. Purdue researchers create templates on retinal tissues
10. Bandage could repair damaged tissues
11. Dried cells, tissues could solve biological materials storage, transport problems

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 14, 2019 , ... Carterra® Inc., ... have opened a Customer Experience Center (CEC) and office in Munich, Germany. Rapid ... , The Munich CEC will be a place for researchers throughout Europe to ...
(Date:8/14/2019)... ... 14, 2019 , ... Representatives with MyBioGate announced that China Focus@Biotech Week will ... “We help innovative projects connect with Chinese pharma and investors in healthcare innovation,” said ... to explain that as a part of Biotech Week Boston – the annual biotech ...
(Date:8/14/2019)... ... August 13, 2019 , ... ... of Molecular Pathology, Institute of Cancer Research (ICR) in a live webinar ... about the process of biomarker and companion diagnostic development including machine learning approaches ...
Breaking Biology News(10 mins):
(Date:7/2/2019)... ... 02, 2019 , ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , ... The film focuses on regenerative veterinary medicine as a means of improving the ... included in the Brentwood and Pacific Palisades International Film Festival in Los Angeles, ...
(Date:6/18/2019)... ... June 18, 2019 , ... Personalized Stem Cells, Inc (“PSC”), ... to the FDA for use of a person’s own adipose-derived stem cells to treat ... in the knee. This IND is the first of several planned clinical trials ...
(Date:6/11/2019)... (PRWEB) , ... June 10, 2019 , ... ... science and technology in an upcoming episode, scheduled to broadcast 4Q/2019. Check your ... Eppendorf Group) and will educate viewers about how its technology facilitates laboratories to ...
(Date:6/11/2019)... ... 11, 2019 , ... Veterinary Regenerative Medicine company, VetStem ... announced that their GMP facility for cell production is now approved by the ... is an important milestone for VetStem as it expands into contract cell manufacturing ...
Breaking Biology Technology:
Cached News: