HOME >> BIOLOGY >> NEWS
Smallpox in 50-year-old tissues detected by integrated diagnostics approach

A rare, preserved specimen of human tissue infected with Variola virus, the causative agent of smallpox, has given scientists the unique opportunity to test modern diagnostic capabilities for the virus.

Smallpox, a devastating disease, was eradicated in 1979 through the efforts of the World Health Organization (WHO). Currently, infectious Variola (a species of the genus Orthopoxvirus) is known to exist only in two WHO-sanctioned repositories, one in Russia and the other at the Centers for Disease Control and Prevention in Atlanta. However, there is concern that undisclosed reference stocks of the virus may exist--and given its potential as a biological threat agent, improved methods of detection and identification are a high priority.

According to an article published in this month's issue of Laboratory Investigation, the specimen used in the study was part of a private collection archived at the Indiana University School of Dentistry. The university investigation determined the specimen--an intact forearm and hand, presumably from a child--to be about 50 years old. It was offered to the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) for further analysis.

"This was a unique chance for us to test all the assays and techniques that we had been working on for a potential biothreat agent--and to do it using a real sample of a disease that no longer occurs," said lead author Randal J. Schoepp. The USAMRIID team included Michelle D. Morin, Mark J. Martinez, David A. Kulesh, Lisa Hensley, Thomas W. Geisbert, and Peter B. Jahrling, with Daniel R. Brady of Indiana University also contributing to the study.

According to Schoepp, working with the specimen was a challenge. It had been maintained under less-than-ideal storage conditions, exposed to extremes of temperature, and preserved in fixative for decades. Nonetheless, it afforded an unparalleled opportunity to test a modern, integrated diagnostic approa
'"/>

Contact: Caree Vander Linden
Caree.Vander-Linden@amedd.army.mil
301-619-2285
US Army Medical Research Institute of Infectious Diseases
29-Jan-2004


Page: 1 2

Related biology news :

1. Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection
2. Smallpox vaccination grinds to halt
3. CDC Telebriefing: Smallpox educational activities and West Nile Virus update
4. Smallpox vaccines
5. Single isolated mouse skin cell can generate into variety of epidermal tissues
6. Patented process preserves transplant tissues/organs
7. Growing replacement teeth and dental tissues
8. Making new muscle: Researchers in Rome produce a mouse that can regenerate its tissues
9. Purdue researchers create templates on retinal tissues
10. Bandage could repair damaged tissues
11. Dried cells, tissues could solve biological materials storage, transport problems

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: