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Smallpox in Europe selected for genetic mutation that confers resistance to HIV infection

Berkeley - People with a genetic mutation that makes them more resistant to the AIDS virus probably have smallpox to thank, according to two population geneticists at the University of California, Berkeley.

About 10 percent of Europeans have a mutation that disables a protein the Human Immunodeficiency Virus (HIV-1) uses to slip into immune system cells. HIV-1 has a harder time infecting people who have a mutation in one of the two genes that code for this receptor protein, and if these people become infected, their disease progresses more slowly. Those with mutations in both copies of the gene are almost completely resistant to the virus

This genetic mutation arose as recently as 700 years ago, and some researchers have suggested that the bubonic plague that devastated Europe periodically over the past 1,000 years may have selected for the mutation by sparing those who lacked one or both copies of the gene.

In a paper appearing this week in the online Early Edition of The Proceedings of the National Academy of Sciences, the two UC Berkeley researchers argue that smallpox, not bubonic plague, is the most likely cause of the spread of this mutation throughout the European population in such a short time.

That is, the same genetic mutation that confers resistance to HIV-1 protects against death from smallpox.

"Our population genetic model finds that genetic selection from plague wouldn't have been sufficient to drive the frequency of this genetic mutation to its current level," said Alison P. Galvani, a Miller Postdoctoral Fellow at UC Berkeley. "It was sufficient for smallpox."

Bubonic plague hasn't been a major source of death in Europe or elsewhere for the last 250 years, while smallpox was only eradicated in 1978, at the same time AIDS (acquired immune deficiency syndrome) appeared. The survival advantage this genetic mutation provided against smallpox has thus been transferred to AIDS, the authors noted.

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Contact: Robert Sanders
rls@pa.urel.berkeley.edu
510-643-6998
University of California - Berkeley
18-Nov-2003


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