Smoking especially dangerous for individuals with gene that causes coronary artery spasm

ATLANTA, Nov. 10 -- Scientists in Japan may have found a genetic cause of coronary artery spasm, a condition that reduces blood supply to the heart causing chest pain or, in severe cases, even a heart attack. They reported their finding today at the American Heart Association Scientific Sessions.

A coronary artery spasm occurs when a coronary artery -- one of the blood vessels supplying blood to the heart -- constricts, then fails to re-open or dilate. Smoking can increase the risk for spasm, but the precise reason for coronary artery spasm has been largely unknown.

In genetic studies, researchers found that mutations in the endothelial nitric oxide synthase (eNOS) gene -- which controls nitric oxide production in the epithelium, or lining, of blood vessel walls -- were prevalent in patients with coronary artery spasm.

Nitric oxide is a key chemical in controlling blood vessel dilation. Varying levels of the chemical stimulate blood vessels to relax or constrict to meet the heart's increasing or decreasing demand for blood flow. "Given that the effects of the gene and smoking are potentially additive, individuals with the gene should be strongly cautioned against smoking," says Michihiro Yoshimura, M.D., Ph.D., and fellow researchers at Kumamoto University in Japan.

"In other studies, we found that nitric oxide activity was deficient in the coronary arteries of patients with coronary spasm," says Yoshimura, lead scientist on the study. "From there we decided to target the eNOS gene to find a genetic cause of coronary artery spasm."

In the study, Yoshimura and colleagues compared risk factors and genetic findings between 201 individuals diagnosed with coronary artery spasm and 345 healthy volunteers. The researchers revealed that the eNOS gene mutation is the most predictive risk factor for coronary artery spasm, followed by cigarette smoking.

Individuals with the gene mutation had twice the risk of having a spasm as

Contact: Carole Bullock
American Heart Association

Page: 1 2

Related biology news :

1. Smoking pot alters more than mood human immune system affected, USF/UCLA study finds
2. Smoking decreases mens chances of fatherhood by IVF and ICSI
3. Smoking, heavy drinking and poor nutrition tend to cluster
4. Smoking during pregnancy found to increase risk of cleft lip and palate
5. Study Indicates Adolescent Smokers Are More Susceptible To Long-Term DNA Damage From Smoking Than Adults Smokers
6. Researchers Find Genetic Connection To Cigarette Smoking
7. Three-Way Gene-Gene-Environmental Exposure Interaction Shown By NIEHS To Escalate Smoking-Related Bladder Cancer
8. Genetic Defect Protects Against Smoking
9. Smokings Effects On Pregnancy Not Mitigated By Prenatal Vitamins, UB Study Finds
10. Diet, Antioxidant Status, And Smoking Habits In French Men
11. Smoking Mice Lead To Emphysema Breakthrough

Post Your Comments:

(Date:7/10/2020)... ... 2020 , ... Today CJ BIO announced the first in a series of ... taste” phenomenon that is revolutionizing ingredient mixes, nutritional content and flavor profiles across a ... July 13, 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT ...
(Date:7/1/2020)... ... July 01, 2020 , ... ... completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, located in the ... clinical supply facility located in Kakegawa, the new 60,000-square-foot facility will provide customers ...
(Date:6/25/2020)... , ... June 24, 2020 , ... ... enterprise software and software-driven clinical data services that accelerate drug development, is collaborating ... selinexor, an XPO1 inhibitor, in hospitalized patients with severe COVID-19. This is the ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... ... chain validation engineering firm, is making available for free its new white ... incorporate concurrent transport simulation testing into today’s biologics licensing application (BLA). In ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON ... of its new tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes ... globe, requiring fast track capacity to provide patients with urgently needed vaccines and ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing solutions ... that they have entered into a strategic partnership whereby Catalent will provide support ...
Breaking Biology Technology:
Cached News: